“…First, simple reaction time resides at a most basic level of cognitive processes, whereas choice and serial reaction time tasks can elicit higher-order processing (i.e., executive function) as evidenced by activation of inhibitory processes and anterior cingulate and prefrontal cortical circuits ( Naito et al, 2000 ; Mulert et al, 2003 ; Burle et al, 2004 ). Second, maintaining vigilant attention and quickly reacting to emerging events is critical for sustained performance in a number of high-stakes tasks including those characteristic of military and first-responder operations ( Truszczynski et al, 2014 ; Vrijkotte et al, 2016 ; Sheffield et al, 2017 ; Dominski et al, 2018 ; Brunyé et al, 2020 ). Finally, reaction time is well-characterized and widely available for efficient download and integration into our modeling approach, and has proven sensitive to variations in acute stress ( Lieberman et al, 2002 ; Olver et al, 2015 ), sleep loss ( Forest and Godbout, 2000 ; Bartel et al, 2004 ; Deslandes et al, 2006 ), and physical exertion ( Chang et al, 2012 ).…”