It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117, 025001 (2016)] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions. DOI: 10.1103/PhysRevE.94.011201 Inertial confinement fusion (ICF) [1] uses lasers or other drivers such as pulsed-power devices or particle accelerators to implode a shell of cryogenic deuterium and tritium (DT). Laser light can be directly incident on the capsule surface (direct drive) or converted into x-rays (indirect drive) through a high-Z enclosure (hohlraum). The shell is imploded to high velocities of hundreds km/s to achieve high central temperatures and areal densities [2]. The hot spot (∼5-10 keV) is a low-density (30-100 g/cm 3 ) core and is surrounded and tamped by a cold (200-500 eV) near Fermi-degenerate dense (300-1000 g/cm 3 ) fuel layer. Fusion alphas produced in the hot spot deposit their energy primarily through collisions with plasma electrons further enhancing the temperature and fusion reaction rate (alpha heating). Under certain conditions of pressure, temperature, and confinement time, alpha heating initiates a burn wave in the surrounding dense shell, leading to fusion energy outputs greatly exceeding the thermal and kinetic energy supplied to the DT fuel by the implosion [2]. Alpha heating is essential for ignition and energy gain in nuclear fusion.In this Rapid Communication we show that recent direct drive OMEGA implosions [3] have achieved core conditions that would lead to significant levels of alpha heating if reproduced at scales typical of the National Ignition Facility (NIF) [4]. At NIF scale, these direct drive targets would yield about 125 kJ of fusion energy, 5× the highest fusion output achieved to date in ICF. The level of alpha heating and yield amplification is predicted to be similar to that achieved with the 1.9 MJ indirect-drive NIF [4] high foot (HF) implosions [5]. These HF implosions have achieved record fusion yields of nearly 1016 neutrons or about 26 kJ of fusion energy [6], demonstrating significant levels of alpha heating. Based on analytic models and detailed numerical simulations [7,8], it was estimated that alpha-particle heating has led to a ∼2-2.5× enhancement of the fusion yield [6,8]. In the absence of alpha heating, the fusion ...