An experiment was carried out in departmental field of Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj during April to July 2021 on Cluster bean (Cyamopsis tetragonoloba) cv. MDU 1 to find out the best suitable combination of organic and inorganic fertilizers for better vegetative growth and yield of cluster bean. The experiment include organic manures like FYM, Poultry Manure, Vermicompost, Goat Manure which were combined in different percentages with reduced dosage of inorganic fertilizers i.e RDF. Twelve treatment combinations were made and replicated thrice in Randomized Block Design. Application of fertilizers and manures was done as per the treatment allocation. The experimental results revealed that treatment T3-75%RDF 18.75:37.5:37.5kg NPK +25%vermicompost 1.25t (5.66) took the minimum number of days to germinate, while vegetative parameters like plant height were recorded maximum in treatment T4-75% RDF 18.75:37.5:37.5 kg NPK+25% Poultry manure 1.25t during the first 30 DAS, later at 60 and 90 DAS treatment T10-50%RDF 12.5:25:25kg NPK +25%FYM 2.5t+25%poultry manure 1.25t was recorded with maximum height (67.04 and 119.09 cm) and maximum no of branches (22.05), first flower bud formation was observed in treatment T3 (33.44 DAS), and yield parameters such as pod yield per plant (265.95 g), total Pod yield (17.72 t/ha), were also recorded significantly maximum in treatment T10.