Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice

Bruin, Natasja de; Mahieu, Michel; Patel, Tarah; Willems, Roland; Lesage, Anne; Megens, Anton

doi:10.1016/j.bbr.2006.05.002

Cited by 17 publications

(11 citation statements)

References 65 publications

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“…Specifically, NET WT mice exhibited delayed rate of acquisition and reduced strength of their aversions. These differences between the lines of wild-type mice is not surprising as previous studies have observed differences in cocaine CTA between C57 and 129 mouse strains (de Bruin et al, 2006; Randall-Thompson et al, 2005). In NET WT and NET KO mice, suppression of saccharin consumption, compared to saline treated mice was only observed following conditioning with 50 mg/kg cocaine.…”

Section: Discussionmentioning

confidence: 74%

Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion

Jones

Hall

Uhl

et al. 2010

Pharmacology Biochemistry and Behavior

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Although cocaine is primarily known for its powerful hedonic effects, there is evidence that its affective experience has a notable aversive component that is less well understood. A variety of pharmacological and molecular approaches have implicated enhanced monoamine (MA) neurotransmission in the aversive effects of cocaine. Although numerous studies have yielded data supportive of the role of the monoamines (indirectly and directly), the specific system suggested to be involved differs across studies and paradigms (Freeman et al. 2005b; Grupp 1977; Roberts & Fibiger, 1975). Monoamine transporter knockout mice have been useful in the study of many different aspects of cocaine effects relevant to human drug use and addiction, yet an assessment of the effects of deletion of the genes for the dopamine, norepinephrine and serotonin transporters (DAT, NET, SERT) on cocaine’s aversive properties has yet to be performed (Uhl et al. 2002). In the current investigation, the strength of cocaine-induced aversions was compared among three groups of transgenic mice with deletions of the genes responsible for the production of one of the monoamine transporters. When compared to their respective WT controls, dopamine transporter deletion slightly attenuated cocaine-induced aversion while deletion of SERT or NET resulted in a more significant delay in the onset and strength of cocaine-induced taste aversions. The data lead us to conclude that the action of cocaine to inhibit NET contributes most substantially to its aversive effects, with some involvement of SERT and minimal contribution of DAT.

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Section: Discussionmentioning

confidence: 74%

Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion

Jones

Hall

Uhl

et al. 2010

Pharmacology Biochemistry and Behavior

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“…It is important to note that it is possible alleles derived from the 129S6 line will flank the mutated gene, whereas alleles derived from the C57BL6 line will flank the wild‐type allele, which may influence the behavioral phenotype (Crusio 2004). A recent study examining visuo‐spatial behavior of these two parental strains, as well as the F2 129 × C57BL6 hybrid strain, using a Morris water maze task suggests that the hybrid strain is superior to either parental strain and the parental strains do not differ from each other on this type of task (Bruin et al 2006). In our study, the dcdc2 del 2 /del 2 and dcdc2 wt/del 2 mice show a persistent deficit in learning to navigate the maze; this phenomenon was not reported in either parental line or the hybrid stain in the Bruin et al (2006) study which showed that all mice, regardless of genetic background, learned the task.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study examining visuo‐spatial behavior of these two parental strains, as well as the F2 129 × C57BL6 hybrid strain, using a Morris water maze task suggests that the hybrid strain is superior to either parental strain and the parental strains do not differ from each other on this type of task (Bruin et al 2006). In our study, the dcdc2 del 2 /del 2 and dcdc2 wt/del 2 mice show a persistent deficit in learning to navigate the maze; this phenomenon was not reported in either parental line or the hybrid stain in the Bruin et al (2006) study which showed that all mice, regardless of genetic background, learned the task. Although the type of motivation utilized in these two visuo‐spatial tasks are different, these data suggest that the deficit we see is likely because of the Dcdc2 mutation.…”

Section: Discussionmentioning

confidence: 99%

Mutation of the dyslexia-associated geneDcdc2impairs LTM and visuo-spatial performance in mice

Gabel

Marin

LoTurco

et al. 2011

Genes, Brain and Behavior

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Developmental reading disorder (RD) affects 5–10% of school aged children (American Psychiatric Association, 2000), with a heritability of approximately 60% (Astrom et al., 2011). Genetic association studies have identified several candidate RD susceptibility genes, including DCDC2, however a direct connection between the function of these genes and cognitive or learning impairments remains unclear (Gabel et al., 2010, Paracchini et al., 2007). Variants in DCDC2, a member of the doublecortin family of genes, have been associated in humans with RD and ADHD and Dcdc2 may play a role in neuronal migration in rats (Burbridge et al., 2008, Meng et al., 2005). In this study, we examined the effect of dcdc2 mutation on cognitive abilities in mice using a visual attention and visuo-spatial learning and memory task. We demonstrate that both heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits. These behavioral deficits occur in the absence of neuronal migration disruption in the mutant mice, and may be comorbid with an anxiety phenotype. These are the first results to suggest a direct relationship between induced mutation in Dcdc2 and changes in behavioral measures. Dcdc2 mutant mice should prove useful in future studies designed to further dissect the underlying neural mechanisms that are impaired following Dcdc2 mutation.

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“…129S6/ SvEvTac acquired the Morris water maze faster than C57Bl/6J in one study (Clapcote and Roder 2004), while data generated in-house at Roche show that C57Bl/6J performed a probe trial better than 129/Ola mice at a time period comparable to the second probe trial in the present study. It is interesting to note that another study demonstrated that an F2 generation hybrid of the C57Bl/6J and 129sv strains acquired the task significantly better than either of the parental inbred strains (de Bruin et al 2006). Thus, the differences observed between the performances of these two NK 3 knockout lines may be related to different genetic backgrounds, which could mean that genetic influences are paramount to determining effects of NK 3 receptor blockade.…”

Section: Discussionmentioning

confidence: 99%

Cognitive performance in neurokinin 3 receptor knockout mice

et al. 2008

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Rationale The neurokinin 3 (NK 3 ) receptor is a novel target under investigation for improvement of the symptoms of schizophrenia due to its ability to modulate dopaminergic signaling. However, research on effects of NK 3 antagonism with animal models has been hindered because of species differences in the receptor between humans, rats, and mice. Objectives The aim of the present study is to further knowledge on the role of NK 3 in cognitive functioning by testing the effect of knockout of the NK 3 receptor on tests of working memory, spatial memory, and operant responding. Materials and methods NK 3 knockout mice generated on a C57Bl/6 background were tested in delayed matching to position (DMTP), spontaneous alternation, Morris water maze, and active avoidance tasks. Results NK 3 knockout mice showed better performance in the DMTP task, though not delay dependently, which points to an effect on operant performance but not on working memory. No differences were seen between the groups in spontaneous alternation, another indication that working memory is not affected in NK 3 knockouts. There was no impairment in knockout mice in Morris water maze training, and the mice also showed faster response latency in the active avoidance task during training. Conclusions Collectively, these results support a role for the NK 3 receptor in performance of operant tasks and in spatial learning but not in working memory.

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Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice

Cited by 17 publications

References 65 publications

Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion

Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion

Mutation of the dyslexia-associated geneDcdc2impairs LTM and visuo-spatial performance in mice

Cognitive performance in neurokinin 3 receptor knockout mice

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