Performance of tPSA and f/tPSA for prostate cancer in Chinese. A systematic review and meta-analysis

Wang, Y; Sun, Guijiang; Pan, Jin; Guo, Zhanjun; Li, T

doi:10.1038/sj.pcan.4500906

Cited by 14 publications

(11 citation statements)

References 5 publications

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“…The most common PSA derivative is the ratio of free PSA to total PSA, and the recommend cut-off is 0.14–0.16 in some Asian countries. 83 84 However, the effects of PSA derivatives are affected by differences in prostate volume. Lam et al .…”

Section: Diagnosismentioning

confidence: 99%

Prostate cancer in East Asia: evolving trend over the last decade

Zhu

Wang

et al. 2015

Asian J Androl

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Prostate cancer is now becoming an emerging health priority in East Asia. Most of our current knowledge on Prostate cancer has been generated from studies conducted in Western population; however, there is considerable heterogeneity of Prostate cancer between East and West. In this article, we reviewed epidemiologic trends, risk factors, disease characteristics and management of Prostate cancer in East Asian population over the last decade. Growing evidence from East Asia suggests an important role of genetic and environmental risk factors interactions in the carcinogenesis of Prostate cancer. Exposure to westernized diet and life style and improvement in health care in combination contribute substantially to the increasing epidemic in this region. Diagnostic and treatment guidelines in East Asia are largely based on Western knowledge. Although there is a remarkable improvement in the outcome over the last decade, ample evidence suggests an inneglectable difference in diagnostic accuracy, treatment efficacy and adverse events between different populations. The knowledge from western countries should be calibrated in the Asian setting to provide a better race-based treatment approach. In this review, we intend to reveal the evolving trend of Prostate cancer in the last decade, in order to gain evidence to improve Prostate cancer prevention and control in East Asia.

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Section: Diagnosismentioning

confidence: 99%

Prostate cancer in East Asia: evolving trend over the last decade

Zhu

Wang

et al. 2015

Asian J Androl

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“…The most accurate PSA derivative is the ratio of free PSA to total PSA, and the recommend cutoff is 0.14-0.16 in some Asian countries. 68,69 At the same time, PSA density, PSA velocity and PSA doubling time are also used occasionally. 70 A combination of these indices may reduce the number of repeat biopsies when the PSA level is between 4 and 10 ng ml 21 .…”

Section: Prostate Cancer (Pca) Epidemiological Characteristicsmentioning

confidence: 99%

An overview of prostate diseases and their characteristics specific to Asian men

Xia¹,

Cui²,

Jiang³

2012

Asian J Androl

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In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia (BPH), prostate cancer (PCa) and chronic prostatitis (CP) that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of these diseases, we find that Asians have a lower incidence of PCa than whites, but the incidences of BPH and CP are similar. Asian men with CP often suffer from fewer disease sites, but have a higher frequency of pain during urination rather than after sexual climax. Prostate-specific antigen (PSA) is a widely used marker for the diagnosis of PCa in both Asian and Western countries. Although the PSA level may be lower in Asians, the threshold used is based on whites. After reviewing the treatments available for these diseases, we did not find a fundamental difference between Asians and whites. Furthermore, the selection for the most appropriate treatment based on the individual needs of patients remains a challenge to urologists in Asia. After considering the traits of prostate diseases that are specific to Asian men, we hope to pave the way for the development of specific diagnostic and therapeutic strategies targeted specifically to Asian men.

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“…Although several studies of %fPSA in China indicated an improvement in diagnostic accuracy over PSA alone [12] , [13] , these studies were mostly published in Chinese journals with limitations with respect to sample size. In this study, we attempted to examine the effectiveness of %fPSA in a retrospective multi-center Chinese cohort.…”

Section: Introductionmentioning

confidence: 99%

Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0–10.0 ng/mL: Results from the Chinese Prostate Cancer Consortium

Chen

Xie

Cai³

et al. 2015

Asian Journal of Urology

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ObjectiveTo test the diagnostic performance of percent free prostate-specific antigen (%fPSA) in predicting any prostate cancer (PCa) and high-grade prostate cancer (HGPCa) in a retrospective multi-center biopsy cohort with a PSA level of 4.0–10.0 ng/mL in China.MethodsConsecutive patients with a PSA of 4.0–10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st, 2010 to December 31st, 2013. Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization (WHO) standard. The diagnostic accuracy of PSA, %fPSA, and %fPSA in combination with PSA (%fPSA + PSA) was determined using the area under the receiver operating characteristic (ROC) curve (AUC).ResultsA total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included, and the detection rate of PCa was 25.1%. The AUC of %fPSA and %fPSA + PSA in predicting any PCa was superior to PSA alone in men aged ≥60 years (0.623 vs. 0.534, p < 0.0001) but not in men aged 40–59 years (0.517 vs. 0.518, p = 0.939). Similar result was yield in predicting HGPCa.ConclusionIn a clinical setting of Chinese men with 4.0–10.0 ng/mL PSA undergoing initial prostate biopsy, adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients ≥60 but not in patients aged 40–59 years.

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Performance of tPSA and f/tPSA for prostate cancer in Chinese. A systematic review and meta-analysis

Cited by 14 publications

References 5 publications

Prostate cancer in East Asia: evolving trend over the last decade

Prostate cancer in East Asia: evolving trend over the last decade

An overview of prostate diseases and their characteristics specific to Asian men

Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0–10.0 ng/mL: Results from the Chinese Prostate Cancer Consortium

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