Performance responses of broilers and pigs fed diets with β-mannanase

Kipper, Marcos; Andretta, Inés; Quadros, Vinícius Rodrigues de; Schroeder, Bruna; Pires, Paula Gabriela da Silva; Franceschina, Carolina Schell; Hickmann, Felipe; França, Ismael

doi:10.37496/rbz4920180177

Cited by 10 publications

(15 citation statements)

References 57 publications

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“…However, the utility in animal nutrition is dependent on the mechanism of action (Kiarie et al, 2013). For example, feed bmannanase has been demonstrated to benefit growth performance and digestibility in pigs and poultry, as summarized in numerous reviews (Shastak et al, 2015;Torres-Pitarch et al, 2019;Saeed et al, 2019;Kipper et al, 2020;Kiarie et al, 2021). However, native/intact feed b-mannans, the target substrate for bmannanase, not only have anti-nutrient properties but have also been linked to stimulating immune responses with implications on post-absorptive nutrients utilization.…”

Section: Introductionmentioning

confidence: 99%

Does supplementing β-mannanase modulate the feed-induced immune response and gastrointestinal ecology in poultry and pigs? An appraisal

2022

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The provision of adequate and balanced nutrients is critical for efficient and profitable animal protein production. However, non-nutritive components in feedstuffs can elicit responses that can negatively impact nutrient utilization efficiency. For example, dietary β-mannans are recognizable by cell surface mannose receptors are pivotal for diverse cellular functions. This review will evaluate the physiological implications of dietary native β-mannans, the utility of supplemental feed β-mannanase in hydrolyzing β-mannans, and subsequent metabolic responses. Dietary native β-mannans have been implicated in inadvertent stimulation of immune response through a phenomenon called the feed-induced immune response (FIIR), that has been associated with intestinal inflammation and depression in animal performance. Supplemental β-mannanase blunted the FIIR by hydrolyzing native β-mannans to smaller fragments with a reduced ability to stimulate the innate immune system as indicated by the modulation of oxidative stress, mucosal permeability, and blood concentration of acute phase proteins and immunoglobulins in broilers and piglet models. Moreover, β-mannanase hydrolysis of native β-mannans to mannooligosaccharides (MOS) impacted gastrointestinal microbial ecology. Indeed, β-mannanase-derived MOS reduced the concentration of pathogenic bacteria such as Escherichia coli and Salmonella and increased the production of short-chain fatty acids in gastrointestinal tracts of various animal models. Consequently, by hydrolyzing native β-mannans, supplemental β-mannanase may have nutritional, metabolic, and microbial ecology benefits. In summary, integrating multi-functional feed additives such as β-mannanase into feeding programs for monogastric animals will be critical for efficient and sustainable animal protein production in the context of evolving challenges such as the mandated elimination of use of antibiotics for growth promotion.

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Section: Introductionmentioning

confidence: 99%

Does supplementing β-mannanase modulate the feed-induced immune response and gastrointestinal ecology in poultry and pigs? An appraisal

2022

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“…As such, supplemental β-mannanase may have nutritional and metabolic benefits. Review on application of single β-mannanase on growth performance and digestibility in broiler chickens and pigs has been reported ( Shastak et al, 2015 ; Saeed et al, 2019 ; Torres-Pitarch et al, 2019 ; Kipper et al, 2020 ). However, these studies were limited in scope in terms of species coverage to document comparative responses within and between species.…”

Section: Introductionmentioning

confidence: 99%

Significance of single β-mannanase supplementation on performance and energy utilization in broiler chickens, laying hens, turkeys, sows, and nursery-finish pigs: a meta-analysis and systematic review

Kiarie

Steelman

Martinez

2021

Translational Animal Science

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This review will give a brief description of β-mannans, abundance in feedstuffs, utility of supplemental feed β-mannanase and subsequent animal responses. Soybean products and co-products of processing palm, coconut and guar seeds are the major sources of β-mannans in poultry and livestock feed. β-mannans are linear polymers of mannose residues linked by β-1,4 glycosidic bonds and their ingestion elicit undesirable and metabolically costly responses. Web of Science was searched to retrieve published studies for meta-analyses of the impact of supplemental β-mannanase on performance and digestibility in pigs and poultry. The mean difference (MD) between ß-mannanase and control on average daily gain (ADG, g/d) was +0.23 (P=0.013; 95% CI 0.05; 0.41), +10.8 g/d (P=0.0005; 95% CI of 6.6; 15.0 g/day) and +20.68 (P<0.000; 95% CI of 17.15; 24.20 g/day) for broiler chickens, nursery pigs and grow-finish pigs, respectively. The MD on β-mannanase improvement on FCR was -0.02 (P<0.0001) with 95% CI (-0.03; -0.02) suggesting a 2-to-3-point FCR improvement in broiler chickens. ß-mannanase improvement on gain to feed (G:F) was +13.8 g/kg (P=0.027; 2.1; 25.4 g/kg) and +8.77 g/kg (6.32; 11.23 g/kg) in nursery and grow-finish pigs, respectively. β-mannanase improved AMEn by 47 kcal/kg (P=0.0004) with 95% CI (28.8; 65.7 kcal/kg) in broiler chickens. The improvement of gross energy digestibility in pigs was 1.08 percentage unit with 95% CI (0.90; 1.26) translating to the release of between 30.6 and 42.8 kcal/kg of digestible energy. Although data was limited, β-mannanase improved egg production but had no impact on egg quality in laying hens. Turkeys may be more adversely affected by ß-mannans because of the high protein/ amino acids requirements necessitating higher dietary inclusion of soybean meal. However, growth performance and feed efficiency responses of turkeys fed diets supplemented with β-mannanase was variable. In summary, ß-mannanase supplementation improved performance linked to energy and nutrient utilization. However, the magnitude of response was variable within and between species indicating further application refinement is warranted to achieve consistent efficacy, including an improved understanding of the functional contribution of β-mannans hydrolysis products.

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“…Based on this, dietary supplementation of β-mannanase has been attributed to the hydrolysis of β-mannans reducing the immune response capacity induced by feeding ( 2 ), and energy expenditure for immune system activation ( 5 ). This nutritional strategy also allows the use of phytase enzyme, known to improve the availability of phosphorus and calcium in diets containing phytate molecules ( 3 ), and providing additional energy and improving energy efficiency ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…Diets supplemented with a blend of these enzymes may be of economic-environmental-nutritional interest. Indeed, β-mannanase has been previously reported to reduce feed to gain ratio and increase nutrient ATTD ( 5 ). Greater phosphorus and lower neutral detergent fiber digestibility were reported when combined xylanase-phytase were supplemented in the diet of grower pigs ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

β-mannanase supplementation in diets reduced in 85 kcal metabolizable energy/kg containing xylanase-phytase improves gain to feed ratio, nutrient usage, and backfat thickness in finisher pigs

et al. 2023

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This study aimed to assess the effects of β-mannanase supplementation in metabolizable energy (ME)-reduced diets containing xylanase-phytase on performance, fecal score, blood biochemical and immunological profile, apparent total tract digestibility (ATTD), digesta passage rate, fecal microbiome, carcass traits and meat quality in finisher pigs (n = 40 entire male hybrid, 26.0 ± 0.9 kg) randomly assigned to 1 of 4 dietary treatments: a control diet containing isolated phytase and xylanase valued at 40 kcal of ME/kg (CD0), CD0 + β-mannanase (0.3 g/kg valued at 30 kcal of ME/kg) (CD70), CD0 + β-mannanase (0.3 g/kg valued at 45 kcal of ME/kg) (CD85), and CD0 + β-mannanase (0.3 g/kg valued at 60 kcal of ME/kg) (CD100), with 10 pen replicates. Pigs fed CD0 diet showed (P = 0.002) greater ADFI. However, pigs fed CD0 diet showed (P = 0.009) lower G:F than those provided CD70 or CD85 diets. A greater (P < 0.001) superoxide dismutase concentration was observed in pigs fed CD70 diet. Pigs fed CD85 diet showed (P = 0.002) greater digestible protein than pigs fed CD0 or CD100 diets. Pigs fed CD70 diet showed an increase of 11.3% in digestible protein than those fed CD0 diet. In addition, greater (P < 0.001) digestible energy was observed in pigs fed CD85 diet. Pigs fed CD0 or CD100 diets showed greater (P < 0.05) Firmicutes:Bacteroidota ratio than those fed CD85 diet. The Muribaculaceae was more abundant (P = 0.030) in pigs fed CD70 diet than in those fed CD0 diet. The Prevotella was more abundant (P = 0.045) in pigs fed CD85 diet than in those fed CD100 diet. In conclusion, β-mannanase supplementation in diets containing xylanase-phytase allows reducing 85 kcal of ME/kg because it improves gain to feed ratio, energy and protein usage, and backfat thickness without metabolic and intestinal ecosystem disorders in finisher pigs.

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Performance responses of broilers and pigs fed diets with β-mannanase

Cited by 10 publications

References 57 publications

Does supplementing β-mannanase modulate the feed-induced immune response and gastrointestinal ecology in poultry and pigs? An appraisal

Does supplementing β-mannanase modulate the feed-induced immune response and gastrointestinal ecology in poultry and pigs? An appraisal

Significance of single β-mannanase supplementation on performance and energy utilization in broiler chickens, laying hens, turkeys, sows, and nursery-finish pigs: a meta-analysis and systematic review

β-mannanase supplementation in diets reduced in 85 kcal metabolizable energy/kg containing xylanase-phytase improves gain to feed ratio, nutrient usage, and backfat thickness in finisher pigs

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