Perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode: A case report

Kutsuna, Fumiya; Tateishi, Yohei; Yamashita, Kairi; Kanamoto, Tadashi; Hirayama, Takuro; Shima, Tomoaki; Nagaoka, Atsushi; Yoshimura, Shunsuke; Miyazaki, Tatsuhiko; Sone, Jun; Izumo, Tsuyoshi; Tsujino, Akira

doi:10.1016/j.cccb.2022.100127

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…We read with interest the article by Katsuna et al. about a 63 years-old male with slowly progressive neuronal intra-nuclear inclusion disease (NIID) who suddenly developed a stroke-like episode (SLE) clinically manifesting as transient speech disturbance and dysgraphia for two hours [1] . In addition to NIID, his previous history was positive for arterial hypertension and diabetes [1] .…”

Section: Letter To the Editormentioning

confidence: 99%

“…about a 63 years-old male with slowly progressive neuronal intra-nuclear inclusion disease (NIID) who suddenly developed a stroke-like episode (SLE) clinically manifesting as transient speech disturbance and dysgraphia for two hours [1] . In addition to NIID, his previous history was positive for arterial hypertension and diabetes [1] . Because cerebral magnetic resonance imaging (MRI) showed hypoperfusion in the left temporo-occipital region on perfusion weighted imaging (PWI), the transient episode was interpreted as stroke mimic in connection with the NIID [1] .…”

Section: Letter To the Editormentioning

confidence: 99%

“…In addition to NIID, his previous history was positive for arterial hypertension and diabetes [1] . Because cerebral magnetic resonance imaging (MRI) showed hypoperfusion in the left temporo-occipital region on perfusion weighted imaging (PWI), the transient episode was interpreted as stroke mimic in connection with the NIID [1] . The study is appealing but raises concern that should be further discussed.…”

Section: Letter To the Editormentioning

confidence: 99%

“…An argument against a perfusion deficit is that the patient did not develop any clinical manifestations corresponding to the area of hypoperfusion. A second argument against a perfusion deficit is that PWI hypointensity did not correlate with the hyperintensities on DWI [1] . Apparent diffusion coefficient (ADC) maps were isointense [1] .…”

Section: Letter To the Editormentioning

confidence: 99%

“…A second argument against a perfusion deficit is that PWI hypointensity did not correlate with the hyperintensities on DWI [1] . Apparent diffusion coefficient (ADC) maps were isointense [1] . A third argument against a perfusion deficit in the left temporo-occipital area is that the DWI lesions concerned the cortico-medullary junction in both hemispheres [1] .…”

Section: Letter To the Editormentioning

confidence: 99%

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A comment on a case report about perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode

Finsterer¹

2023

Cerebral Circulation - Cognition and Behavior

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Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

See 3 more Smart Citations

A comment on a case report about perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode

Finsterer¹

2023

Cerebral Circulation - Cognition and Behavior

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Neuronal Intranuclear Inclusion Disease Presented with Acute Aphasia

Kim,

Park,

Shin

2024

J Korean Neurol Assoc

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Neuronal intranuclear inclusion disease (NIID) is a rare disorder with slowly progressive neurodegeneration. Major clinical presentation is dementia, but some patients can have episodic symptoms. This is a rare case of NIID presented with acute aphasia. A 62-years-old male visited emergency room presenting with aphasia. On brain magnetic resonance imaging, a U-shaped diffusion high signal intensity lesion in bilateral frontal corticomedullary junction was observed. A skin biopsy showed intranuclear cytoplasmic inclusion bodies, so he was diagnosed as NIID.

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Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy

Bu,

Torres,

Robinson

et al. 2023

Front. Neurol.

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Neuronal intranuclear inclusion disease (NIID), a neurodegenerative disease previously thought to be rare, is increasingly recognized despite heterogeneous clinical presentations. NIID is pathologically characterized by ubiquitin and p-62 positive intranuclear eosinophilic inclusions that affect multiple organ systems, including the brain, skin, and other tissues. Although the diagnosis of NIID is challenging due to phenotypic heterogeneity, a greater understanding of the clinical and imaging presentations can improve accurate and early diagnosis. Here, we present three cases of pathologically proven adult-onset NIID, all presenting with episodes of acute encephalopathy with protracted workups and lengthy time between symptom onset and diagnosis. Case 1 highlights challenges in the diagnosis of NIID when MRI does not reveal classic abnormalities and provides a striking example of hyperperfusion in the setting of acute encephalopathy, as well as unique pathology with neuronal central chromatolysis, which has not been previously described. Case 2 highlights the progression of MRI findings associated with multiple NIID-related encephalopathic episodes over an extended time period, as well as the utility of skin biopsy for antemortem diagnosis.

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Perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode: A case report

Cited by 4 publications

References 5 publications

A comment on a case report about perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode

A comment on a case report about perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode

Neuronal Intranuclear Inclusion Disease Presented with Acute Aphasia

Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy

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