Perhexiline Maleate As a Cause of Reversible Parkinsonism and Peripheral Neuropathy

Abstract

In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed. The neuropathy was confirmed by electromyographic and nerve conduction studies. The parkinsonism and peripheral neuropathy disappeared when perhexiline maleate was discontinued.

Targeting NOX enzymes in the central nervous system: therapeutic opportunities

“…However, such an indication should, unfortunately, not be recommended for this compound because in many cases it induces drug-induced neuropathies [49,133]. NOX inhibitors are currently developed by both academic [18] and industrial laboratories, such as Shionogi or Mitsubishi, for which only patents have been published (for review, see [69,75], but, unfortunately, BBB penetration or efficacy in CNS indications has to our knowledge not been published.…”

Drug-Induced Parkinsonism and Other Movement Disorders

“…120 Included in the more bizarre examples of reversible parkinsonism are a 47 year old female who developed the classic signs and symptoms after the intramuscular injection of procaine 121 and a 78 year old woman with reversible parkinsonism and peripheral neuritis after taking perhexiline maleate for intractible angina pectoris. 122 The beta adrenergic blocker pindolol combined with clopamide used in the treatment of hypertension has been reported as causing or precipitating parkinsonism in two patients 123 and meperidine 124 as well as the neuroleptanalgesic mixture of fentanyl and droperidol have each produced a reversible parkinsonism.…”