Peri-Implant Mucositis Treatment with a Chlorexidine Gel with A.D.S. 0.5%, PVP-VA and Sodium DNA vs a Placebo Gel: A Randomized Controlled Pilot Clinical Trial

Abstract

Background: Peri-implant mucositis is a bacterial and inflammatory disease of implant surrounding soft tissues. Chlorhexidine (CHX) associated with PVP-VA (Polyvinylpyrrolidone/vinyl acetate) has an adjuvant function in the antibacterial activity: it protects the filmforming layer, due to polymer, from microbial contamination or over-infection, and prolongs its permanence, without a direct action on the tissues and wounds. Sodium DNA is able to improve gingival trophism. The aim of the study was to compare a gel with CHX and antidiscoloration system (A.D.S.) 0.5% with the addition of PVP-VA and sodium DNA with a placebo gel without chlorexidine in periimplant mucositis treatment. Methods: Trial design: A single center randomized controlled pilot clinical trial was conducted on a total of 24 patients with mucositis, randomly allocated into two groups. In the group (A) (n = 12) patients were treated with a gel with CHX + A.D.S. 0.5% while a placebo gel was used in the group (B) (n = 12). Outcome: Plaque Index (PI) (primary outcome), Bleeding on probing (BOP) and Gingival Index (GI) (secondary outcomes) were assessed at baseline and at 2 weeks after treatment period. Results: Mean PI score recorded at baseline was 2.4 ± 0.4 [95% CI: -2.682/7.482] in the group (A) and 2.2 ± 0.5 [95% CI: -4.153/8.553] in the group (B) (p > 0.05) while mean PI score at 2 weeks was 0.5 ± 0.4 [95%

Surface Coatings of Dental Implants: A Review

“…Peri-implantitis is an inflammatory condition that affects all surrounding tissues [96]. A deep pocket with hemorrhage, suppuration, and slight bone loss accompanies mucosal injury [33,97,98] (Figure 8).…”

“…A deep pocket with hemorrhage, suppuration, and slight bone loss accompanies mucosal injury [33,97,98] (Figure 8). Therefore, a recent scientific study has focused on the interface between the implant and the surrounding soft tissues, highlighting the significance of establishing a sufficient epithelial biological seal that is necessary to prevent bacterial contamination Therefore, a recent scientific study has focused on the interface between the implant and the surrounding soft tissues, highlighting the significance of establishing a sufficient epithelial biological seal that is necessary to prevent bacterial contamination [17,97,99,100]. The underlying bone tissues are shielded from germs by the peri-implant tissues, which are made up of connective and epithelial components [101].…”