Peri-Implantitis in Relation to Titanium Corrosion: Current Status and Future Perspectives

Xu, Angela J.; Alhamad, Mostafa; Ramachandran, Remya Ampadi; Shukla, A K; Barão, Valentim Adelino Ricardo; Sukotjo, Cortino; Mathew, Mathew T.

doi:10.1007/s40735-022-00644-6

Cited by 8 publications

(7 citation statements)

References 63 publications

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“…Generally, the thinner the coating, the greater its adhesion strength to the substrate, and the poorer its corrosion protection [ 86 ]. In addition, detachment of the coatings might cause the accumulation of debris in the surrounding tissue and consequently cause inflammation and exacerbate immunological responses [ 32 ]. Nevertheless, some reports relate the thickness of the coatings with the enhancement of osteogenic properties [ 87 ], and the increasing bone attachment to the implant in an in vivo system [ 88 ] but always related to another surface feature influenced by coatings thickness, such as surface zeta-potential and porous surface structure.…”

Section: Discussionmentioning

confidence: 99%

“…Although TiO 2 continues to be one of the best options for manufacturing orthopedic implants, reports warn about its toxicity [ 30 ]. In most cases, these problems are related to the damage in the oxide layer due to corrosion, causing the release of particles that lead to peri-implantitis [ 32 ]. According to the present results, ZrO 2 represents a potential alternative to TiO 2 , displaying ZrO 2 a similar osteoinduction process to that of TiO 2 ; nevertheless, further studies on the mechanisms and timewise proceeding of the differentiation process on these oxides are needed .…”

Section: Discussionmentioning

confidence: 99%

“…However, the extensive use of Ti-based and TiO 2 materials has raised concerns regarding their low bioactivity, decreasing corrosion resistance in F − or Cl − containing media after long-term use, and the consequent adverse effects of titanium accumulation and its effects on the human body [ 3 , 10 , 27 , 28 , 29 ]. Reports about Ti-associated allergic reactions and hypersensitivity demand research on alternative materials [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

et al. 2022

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Biomaterials with adequate properties to direct a biological response are essential for orthopedic and dental implants. The surface properties are responsible for the biological response; thus, coatings with biologically relevant properties such as osteoinduction are exciting options to tailor the surface of different bulk materials. Metal oxide coatings such as TiO2, ZrO2, Nb2O5 and Ta2O5 have been suggested as promising for orthopedic and dental implants. However, a comparative study among them is still missing to select the most promising for bone-growth-related applications. In this work, using magnetron sputtering, TiO2, ZrO2, Ta2O5, and Nb2O5 thin films were deposited on Si (100) substrates. The coatings were characterized by Optical Profilometry, Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, X-ray Photoelectron Spectroscopy, X-ray Diffraction, Water Contact Angle measurements, and Surface Free Energy calculations. The cell adhesion, viability, proliferation, and differentiation toward the osteoblastic phenotype of mesenchymal stem cells plated on the coatings were measured to define the biological response. Results confirmed that all coatings were biocompatible. However, a more significant number of cells and proliferative cells were observed on Nb2O5 and Ta2O5 compared to TiO2 and ZrO2. Nevertheless, Nb2O5 and Ta2O5 seemed to induce cell differentiation toward the osteoblastic phenotype in a longer cell culture time than TiO2 and ZrO2.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

et al. 2022

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“…However, concerns have arisen regarding the extensive use of Ti-based and TiO 2 materials, including their limited bioactivity, reduced corrosion resistance in media containing F − or Cl − over prolonged periods, and the resulting adverse effects of titanium accumulation on the human body [ 149 , 150 , 151 ]. Reports of allergic reactions and hypersensitivity associated with titanium necessitate research into alternative materials [ 152 , 153 ].…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers

et al. 2023

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Patients suffering bone fractures in different parts of the body require implants that will enable similar function to that of the natural bone that they are replacing. Joint diseases (rheumatoid arthritis and osteoarthritis) also require surgical intervention with implants such as hip and knee joint replacement. Biomaterial implants are utilized to fix fractures or replace parts of the body. For the majority of these implant cases, either metal or polymer biomaterials are chosen in order to have a similar functional capacity to the original bone material. The biomaterials that are employed most often for implants of bone fracture are metals such as stainless steel and titanium, and polymers such as polyethene and polyetheretherketone (PEEK). This review compared metallic and synthetic polymer implant biomaterials that can be employed to secure load-bearing bone fractures due to their ability to withstand the mechanical stresses and strains of the body, with a focus on their classification, properties, and application.

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“…It is known from the literature that the cause of mucositis and peri-implantitis can include titanium ions and nanoparticles as degradation products of medical products under conditions of functional load [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. In 2021, works appeared that were devoted to the genetic and immunological aspects of the interaction of titanium nanoparticles with macrophages and studies of gene expression during their co-culture [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Immunopathological Inflammation in the Evolution of Mucositis and Peri-Implantitis

Labis

Bazikyan

Сизова

et al. 2022

IJMS

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The purpose of this study was to provide an immuno-mediated substantiation of the etiopathogenesis of mucositis and peri-implantitis based on the results of experimental, laboratory and clinical studies. The biopsy material was studied to identify impregnated nanoscale and microscale particles in the structure of pathological tissues by using X-ray microtomography and X-ray fluorescence analyses. Electron microscopy with energy-dispersive analysis identified the composition of supernatants containing nanoscale metal particles obtained from the surfaces of dental implants. The parameters of the nanoscale particles were determined by dynamic light scattering. Flow cytometry was used to study the effect of nanoscale particles on the ability to induce the activation and apoptosis of immunocompetent cells depending on the particles’ concentrations during cultivation with the monocytic cell line THP-1 with the addition of inductors. An analysis of the laboratory results suggested the presence of dose-dependent activation, as well as early and late apoptosis of the immunocompetent cells. Activation and early and late apoptosis of a monocytic cell line when THP-1 was co-cultured with nanoscale metal particles in supernatants were shown for the first time. When human venous blood plasma was added, both activation and early and late apoptosis had a dose-dependent effect and differed from those of the control groups.

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Peri-Implantitis in Relation to Titanium Corrosion: Current Status and Future Perspectives

Cited by 8 publications

References 63 publications

Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers

Immunopathological Inflammation in the Evolution of Mucositis and Peri-Implantitis

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