Peri-Implantitis Regenerative Therapy: A Review

Mordini, Lorenzo; Sun, Ningyuan; Chang, Nen Chung; Guzman, John-Paul De; Generali, Luigi; Consolo, Ugo

doi:10.3390/biology10080773

Cited by 20 publications

(11 citation statements)

References 61 publications

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“…Different mechanical treatment methods are available, but all available methods cannot guarantee a sufficient biofilm removal or an undamaged implant surface [43]. Follow-up treatment with supplementary bone materials or antimicrobial gels can also support the success of peri-implantitis therapy [44]. However, the key role is played by the decontamination process, which does not damage the rough implant surface structure.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of biofilm removal by combination of water jet and cold plasma: an in-vitro study

et al. 2022

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Background Peri-implantitis therapy is a major problem in implantology. Because of challenging rough implant surface and implant geometry, microorganisms can hide and survive in implant microstructures and impede debridement. We developed a new water jet (WJ) device and a new cold atmospheric pressure plasma (CAP) device to overcome these problems and investigated aspects of efficacy in vitro and safety with the aim to create the prerequisites for a clinical pilot study with these medical devices. Methods We compared the efficiency of a single treatment with a WJ or curette and cotton swab (CC) without or with adjunctive use of CAP (WJ + CAP, CC + CAP) to remove biofilm in vitro from rough titanium discs. Treatment efficacy was evaluated by measuring turbidity up to 72 h for bacterial re-growth or spreading of osteoblast-like cells (MG-63) after 5 days with scanning electron microscopy. With respect to application safety, the WJ and CAP instruments were examined according to basic regulations for medical devices. Results After 96 h of incubation all WJ and CC treated disks were turbid but 67% of WJ + CAP and 46% CC + CAP treated specimens were still clear. The increase in turbidity after WJ treatment was delayed by about 20 h compared to CC treatment. In combination with CAP the cell coverage significantly increased to 82% (WJ + CAP) or 72% (CC + CAP), compared to single treatment 11% (WJ) or 10% (CC). Conclusion The newly developed water jet device effectively removes biofilm from rough titanium surfaces in vitro and, in combination with the new CAP device, biologically acceptable surfaces allow osteoblasts to grow. WJ in combination with CAP leads to cleaner surfaces than the usage of curette and cotton swabs with or without subsequent plasma treatment. Our next step will be a clinical pilot study with these new devices to assess the clinical healing process.

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Section: Discussionmentioning

confidence: 99%

Efficiency of biofilm removal by combination of water jet and cold plasma: an in-vitro study

et al. 2022

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“…The regenerative therapy enables optimal peri-implant conditions and eliminates aetiological causes [ 26 ]. Various grafting materials and membranes are considered when reconstructive peri-implant surgery is indicated [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Autologous Platelet Concentrates (APCs) for Hard Tissue Regeneration in Oral Implantology, Sinus Floor Elevation, Peri-Implantitis, Socket Preservation, and Medication-Related Osteonecrosis of the Jaw (MRONJ): A Literature Review

Mijiritsky

Assaf

Kolerman

et al. 2022

Biology

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Over recent years, the usage of autologous platelet concentrates (APCs) has risen in hard tissue regeneration and oral implantology. The purpose of the present review is to offer an overview of the use of three APC techniques in dentistry: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF). A narrative summary of articles published between January 2011 and April 2022 is provided. The PubMed, Cochrane Library, Scopus, and Embase databases were used to conduct the search. The following keywords were used in the preliminary: “VEGF”, “TGF-b1”, “PRP”, “PRF”, “CGF”, AND “sinus augmentation” OR “implants” OR “peri-implantitis” OR “socket preservation” OR “MRONJ”. A total of 82 articles was finally included. The review then takes into account the application of the three techniques in different areas of treatment—including oral implantology, sinus floor elevation, peri-implantitis, socket preservation, and medication-related osteonecrosis of the jaw (MRONJ)—as well as their advantages and disadvantages.

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“…Secondary bone loss is most commonly caused by metastatic disease, while trauma is the most common cause of macroscopic bone defects. Moreover, in dentistry and in maxillo-facial surgery, the bone loss of the alveolar bone after dental extraction is defined as bone atrophy [ 1 , 2 ]. On the other hand, micro-level investigations on bone damage can shed further light on radiologic and clinical descriptions.…”

mentioning

confidence: 99%

“…In vivo investigations on PEMF stimulation are reviewed, focusing on molecular and morphological improvements in bone in order to better understand the biological mechanism of PEMF and its effect on bone healing so that each researcher/clinician might choose the most appropriate signal for a specific bone disorder in order to obtain a specific result. A wide narrative review [ 2 ] aims to identify the best approach to treat peri-implant diseases that usually lead to bone loss around dental implants, causing implant failure. Despite many investigations aimed at identifying the best approach to treat these conditions, there is still no universally recognized protocol to solve these complications successfully and predictably.…”

mentioning

confidence: 99%

“…A wide narrative review [ 2 ] aims to identify the best approach to treat peri-implant diseases that usually lead to bone loss around dental implants, causing implant failure. Despite many investigations aimed at identifying the best approach to treat these conditions, there is still no universally recognized protocol to solve these complications successfully and predictably.…”

mentioning

confidence: 99%

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