Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review

Abstract

The healing of the periapical tissues is crucial to the success of root canal treatment. The review studies effectively examine various endodontic root canal sealants in terms of periapical healing. This systematic review was formulated following the PRISMA 2020 guidelines and registered in the international prospective register of systematic reviews (PROSPERO) number-CRD42021239192. To find relevant articles, PubMed Central and Medline databases (until February 2022) were searched. Studies that evaluated healing following the application of different endodontic sealers were analysed. A primary outcome measure was the resolution of periapical lesions following the endodontic treatment. In vivo studies comparing radiographic treatment outcomes and articles with a minimum of 6-month follow-up were included. A total of 9 clinical trial studies that met all the inclusion criteria were included in the analysis. The overall risk of bias was high in four studies out of nine studies. Periapical lesions showed significant healing after endodontic treatment regardless of sealer type, although bioceramic and bioactive sealers had shown better results.

Periapical healing outcome following non-surgical endodontic intervention among diabetic patients: A systematic review conducted according to PRISMA guidelines and the Cochrane handbook for systematic reviews of interventions

“…Dental implants, the temporomandibular joint (TMJ), and PH (associated with endodontic therapy) are all related in the context of oral health and comprehensive dental rehabilitation ( Minervini et al, 2023c ; Nicholson et al, 2022). According to the findings of another investigation ( Khandelwal et al, 2022 ), the combined odds ratio (OR) suggested a higher prevalence of PL in patients with DM compared to a CG. This finding aligns with the results of multiple studies ( Aminoshariae et al, 2017 , Khalighinejad et al, 2016 , Vlassara, 1997 ), which cited different cross-sectional studies of varying methodological quality and lacked robust evidence.…”

“…Periapical healing (PH) refers to the biological process through which the periapical tissues surrounding the root apex of a tooth undergo repair and restoration after receiving endodontic treatment ( Khandelwal et al, 2022 ). It is a crucial outcome measure in assessing the success of root canal therapy, as it indicates the resolution of inflammation, elimination of microbial infection, and regeneration of the periapical tissues (Holland et al, 2017).…”

Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment

“…Proper instrumentation, comprehensive disinfection, and obturation are critical to successful root canal treatment. In this context, healing of the periapical tissues is also necessary to contribute to proposed treatment success 3 . However, pain after root canal treatment can occur, being one of the most common side effects, affecting from 3% to 58% of the population 4 .…”

MTA as modulator of periapical tissue healing in rat molar: A histological study

“…Sealers emit substances that interact with the periradicular tissue in different ways and cause different effects. 1 , 2 , 3 , 4 …”

“…It is crucial to comprehend how this biomaterial functions, how it behaves when in touch with other dental materials, and most importantly, what impact does it have on apical tissue and how do the cells around the material react. 4 , 16 …”