Pericardial Effusion and Cardiomyopathy Following Arthritis with Parvovirus B19 Infection: Response to Intravenous Immunoglobulin

Sairam, Shrilekha; Goel, Niti; Lisse, Jeffrey R.; McNearney, Terry A.

doi:10.1097/00124743-200110000-00020

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…To our knowledge, parvovirus B19-associated tamponade had not been reported so far, but there are some cases of pericardial effusion associated with parvovirus B19 infection. 15 Parvovirus B19 has led to acute systemic response, suggestive of Still disease. The virus may represent a trigger for both autoinflammation and autoimmunity.…”

Section: Discussionmentioning

confidence: 99%

Successful Immunotherapy in Life-threatening Parvovirus B19 Infection in a Child

Butin¹,

Mekki

Phan³

et al. 2013

Pediatric Infectious Disease Journal

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We report a case of an immunocompetent child who developed parvovirus B19 infection complicated by autoinflammatory disease with myocarditis, tamponade and macrophage activation syndrome. He recovered with immunotherapy including prednisone, immunoglobulins, cyclosporin and anakinra (anti-interleukin-1). The report shows that parvovirus can provoke severe systemic inflammation with acute heart injury and that anti-interleukin-1 might be considered in such parvovirus-related inflammation.

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Section: Discussionmentioning

confidence: 99%

Successful Immunotherapy in Life-threatening Parvovirus B19 Infection in a Child

Butin¹,

Mekki

Phan³

et al. 2013

Pediatric Infectious Disease Journal

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show abstract

“…There have been 13 cases of B19-associated myositis reported in the literature to date,112–123 including three cases in which myositis formed part of a multiple autoimmune disease occurring in an individual patient,113 121 123 discussed in the section on multiple autoimmune diseases below.…”

Section: Autoimmune Diseases Associated With Parvovirus B19 Infectionmentioning

confidence: 99%

“…There are 12 published case reports showing multiple autoimmune features occurring in individual patients during an acute parvovirus B19 infection,102 113 121 123 162 186 210–215 summarised in table 2. Although few of these cases fit well into any particular type of MAS as described above, it is clear that parvovirus B19 has the ability, albeit rarely, to trigger multiple autoimmune diseases in individual patients.…”

Section: Multiple Autoimmune Diseases Associated With B19 Infection Imentioning

confidence: 99%

The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

Kerr

2015

J Clin Pathol

109

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Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been shown to be key to the pathogenesis of the particular disease process in a significant number of cases, for example, production of rheumatoid factor in cases of B19-associated rheumatoid arthritis and production of anti-glutamic acid decarboxylase (GAD) in patients with B19-associated type 1 diabetes mellitus. B19 infection has also been associated with the development of multiple autoimmune diseases in 12 individuals. Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein.

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Derrame pleural asociado a infección por parvovirus B19

2013

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Pericardial Effusion and Cardiomyopathy Following Arthritis with Parvovirus B19 Infection: Response to Intravenous Immunoglobulin

Cited by 3 publications

References 11 publications

Successful Immunotherapy in Life-threatening Parvovirus B19 Infection in a Child

Successful Immunotherapy in Life-threatening Parvovirus B19 Infection in a Child

The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

Derrame pleural asociado a infección por parvovirus B19

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