Periconceptional use of folic acid in Shanxi Province of northern China

Abstract

Objective: To understand the periconceptional use of folic acid and its association with selected characteristics in northern China. Design: As part of a population-based case-control study on external structural birth defects, we analysed periconceptional use of folic acid among control mothers.

A pilot study on environmental and behavioral factors related to missed abortion

“…Folic acid supplements have been shown to be able to prevent placental abruption [22]. A survey in Shanxi province of China demonstrated that the rate of using folic acid among Chinese women was still low-only 10.2% [23].…”

Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis

“…A comparable mechanism might be that maternal periconceptional use of folic acid and multivitamin supplements contain more folic acid in Europe than in China (Li et al, 2007; van Beynum et al, 2007); a higher dietary intake of folic acid has been shown to be effective in increasing folate concentration in both serum and red blood cells among women of childbearing age since the period of pregnancy (FDA, 1996). van Beynum et al (2006) studied the association between the maternal MTHFR C677T polymorphism and periconceptional folate supplementation on the risk of CHDs in offspring, and mothers with the MTHFR 677TT genotype who did not use periconceptional folate supplements had a 2-fold increased risk of a CHD-affected child.…”

“…Based on the inclusion criteria, only 6 case-control studies (Liu et al, 2002;Yan et al, 2003;Zhu et al, 2006;Zhong et al, 2006;Li et al, 2002Li et al, , 2007 with full-text were included in this meta-analysis and 140 studies were excluded. The flow chart of study selection is summarized in Figure 1.…”

Market Potential of Folate Biofortified Rice in China

“…Together with the Balrampur District in India (Cherian et al, 2005) 14 , this poor coal mining region has one of the highest NTD prevalence rates in the world with rates ranging between 60 and 150 NTDs per 10 000 births (Xiao, 1989;Moore et al, 1997;Dai et al, 2002;Li et al, 2006), up to an NTD rate of 199 (Gu et al, 2007). This high incidence is correlated with the high folate deficiency rates of pregnant women (43.8 %) and the limited use of folic acid pills in this region Li et al, 2007;Ren et al, 2007;Zhang et al, 2008) (see section 5.1.1.). …”