Periconceptional vitamin a use: How much is teratogenic?

Miller, Richard K.; Hendrickx, Andrew G.; Mills, James L.; Hummler, Hans; Wiegand, U.

doi:10.1016/s0890-6238(97)00102-0

Cited by 109 publications

(60 citation statements)

References 50 publications

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“…Hypervitaminosis A can take the form of acute or chronic poisoning. The first of these two forms appears after the IJOMEH 2012;25(2) 108 be administered under strict medical control (it is advisable to eliminate animal liver from the diet) [3,37,38]. High-dose vitamin A therapy in breast-feeding women, which could cause symptoms of hypervitaminosis in infants, is contraindicated [20,21].…”

Section: Potential Riskmentioning

confidence: 99%

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Adverse effects of antioxidative vitamins

Rutkowski¹,

Grzegorczyk²

2012

International Journal of Occupational Medicine and Environmental Health

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High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation with antioxidative vitamins. Toxic effects resulting from erroneous administration of high doses of those substances on organs and systems of the organism are also discussed. Attention is drawn to interactions of antioxidative vitamins with concomitantly used drugs, as well as intensification of adverse effects caused by various exogenous chemical factors. Moreover, the article presents the evaluation of supplementation with these vitamins, which was performed in large studies.

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Section: Potential Riskmentioning

confidence: 99%

“…Like vitamin A, synthetic retinoids increase the risk of osteoporosis. Also, they show embryotoxic and teratogenic activity, so they must not be used during pregnancy and lactation, even at low doses [23,30,31,37,38].…”

Section: Potential Riskmentioning

confidence: 99%

Adverse effects of antioxidative vitamins

Rutkowski¹,

Grzegorczyk²

2012

International Journal of Occupational Medicine and Environmental Health

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“…Hypotheses initially motivating the set-up of the cohort included those regarding the potential influences of protein 5 -8 , vitamin A 9,10 , folic acid 11,12 and n-3 fatty acids 13,14 consumed in pregnancy on pregnancy outcomes and various measures of offspring health. In the current paper we present results from a validation study pertaining to these nutrients.…”

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confidence: 99%

Validity of protein, retinol, folic acid and n–3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort

Mikkelsen

Osler

Olsen

2006

Public Health Nutr.

111

107

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Objective: To validate intakes of protein, folic acid, retinol and n-3 fatty acids estimated from a food-frequency questionnaire in week 25 of pregnancy . Design: Validation was done against a 7-day weighed food diary (FD) and biomarkers of the nutrients in gestation week 32-38. Subjects and setting: The FFQ-25 to be validated was used in the Danish National Birth Cohort comprising 101 042 pregnant Danish women, of whom 88 participated in the present validation study. Results: Estimated intakes of protein, retinol and folic acid did not differ significantly between the two dietary methods, but intake of n-3 fatty acids was one third larger when estimated from the FFQ-25. The intakes estimated from the two dietary methods were all significantly correlated, ranging from 0.20 for retinol intake to 0.57 for folic acid intake. Sensitivities of being correctly classified into low and high quintiles were between 0.22 and 0.77, and specificities were between 0.62 and 0.89. Urinary protein content did not correlate significantly with protein estimated from the FFQ (r ¼ 0.17, P . 0.05), but did with intake estimated from the FD (r ¼ 0.56, P , 0.0001). Erythrocyte folate correlated significantly with the estimated total intake from the FFQ (r ¼ 0.55, P , 0.0001) and the FD (r ¼ 0.52, P , 0.0001). No correlations with plasma retinol were found. Erythrocyte eicosapentaenoic acid (C20:5n2 3) correlated significantly with n-3 fatty acids intake estimated from both the FFQ-25 (r ¼ 0.37, P , 0.001) and the FD (r ¼ 0.62, P , 0.0001). Conclusion: The FFQ-25 gives reasonable valid estimates of protein, retinol and folic acid intakes, but seems to overestimate intake of n-3 fatty acids. A number of hypotheses on the influence of maternal diet during pregnancy on health have been suggested during the last two decades. In Denmark, data on the dietary intake of pregnant women have been collected on a large scale in the Danish National Birth Cohort (DNBC), which is a prospective pregnancy cohort with national coverage 1 . In gestation week 25, a 360-item food-frequency questionnaire (FFQ-25) was mailed to all cohort members. To enable sensible use of these dietary data for aetiological analyses, however, we need information on the validity of the collected dietary information. The questionnaire is a modified version of the food-frequency questionnaire (FFQ) developed at the Danish Cancer Registry 2 , which was validated in a population of 40-64-year-old men and women 3 and young non-pregnant women 4 . Since diet during pregnancy could be different and since pregnant women might be more aware of their dietary habits, it is important to validate the questionnaire in this particular population and describe the degree of misclassification.Hypotheses initially motivating the set-up of the cohort included those regarding the potential influences of protein 5 -8 , vitamin A 9,10 , folic acid 11,12 and n-3 fatty acids 13,14 consumed in pregnancy on pregnancy outcomes and various measures of offspring health. In the current paper we p...

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“…By considering that RDAs for pregnant women are 300 -360 mg/day magnesium and 90 mg/ day ascorbic acid, these results seem to indicate that the RDAs for these nutrients are insufficient for women of reproductive age. Moreover, although the majority of data indicate that vitamin A intake above 3000 mg/day should be avoided in the periconceptional period, this has been recently discussed (Miller et al, 1998;Johansen et al, 2008), and similarly, there is disagreement on the need for iron prophylaxis early in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…However, other results are contrasting (Dolk et al, 1999). In fact, although the overall recommendation is that vitamin A or retinol intake below 3000 mg (10 000 IU)/day is safe, some have argued that vitamin A intake up to 9000 mg (30 000 IU)/day represents harmless levels (Miller et al, 1998). In this context, in a population-based case -control study carried out in Norway no evidence of an increased risk of clefting was found with an intake of total vitamin A or retinol of more than 3000 mg (10 000 IU) (Johansen et al, 2008).…”

Section: Embryogenesismentioning

confidence: 99%