Pericyte Biology in the Optic Nerve and Retina

Barbosa, Bárbara Gonçalves; Cassimiro, Arthur Veríssimo Nascimento Armond; Rocha, Beatriz G S; Alvarenga, Betânia Mara; Birbrair, Alexander; Ribas, Vinícius Toledo

doi:10.1007/s43152-022-00036-5

Cited by 2 publications

(2 citation statements)

References 123 publications

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“…Our results show that the arteriole runs inside the nerve, i.e. within the first 27% of the total nerve’s depth, as opposed to outside of the fiber bundle as suggested previously (Barbosa et al, 2022; May and Lütjen-Drecoll, 2002). A vein several times the size of the arteriole, runs at a depth of 65 µm – 90µm along the entire nerve’s length (Figure 1A, dashed yellow arrows), reaching the most caudal part, where it branches into several venules (Figure 1A, yellow arrows).…”

Section: Resultssupporting

confidence: 89%

Axo-vascular coupling mediated by oligodendrocytes

Restrepo¹,

Trevisiol

Restrepo-Arango³

et al. 2022

Preprint

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The high energy requirements of the cortical gray matter are met by the precise cooperation of neurons, glia, and vascular cells in a process known as neurovascular coupling (NVC). In contrast, the existence and significance of NVC in white matter (WM) are still debated and basic regulatory mechanisms are unknown. We recently discovered that oligodendrocytes sense the spiking axons' activity via NMDA receptors and regulate their cell surface expression of glucose transporter GLUT1 allowing an increase in glycolytic metabolism that enables lactate release to metabolically support the axons. Here, we show for the mouse optic nerve (ON), a model WM tract, that the vascular support is also dynamically controlled. Axonal spiking activity induces small vessel dilations which are sustained for more than 20 minutes upon the ending of electrical stimulation. Pharmacological inhibition shows that the electrically evoked dilation is mediated by the prostaglandin E2 receptor EP4 and can be modulated by the oxygen concentration, as has been shown in the grey matter. Importantly, we found in ONs from conditional mouse mutants that oligodendroglial NMDA receptors are required for this type of neurovascular response, demonstrating a critical role of oligodendrocytes in coupling axonal activity to pericyte function. Reminiscent of NVC in cortical slices, the 'axo-vascular' response is slower and may represent a more rudimentary form of neurovascular coupling.

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Section: Resultssupporting

confidence: 89%

Axo-vascular coupling mediated by oligodendrocytes

Restrepo¹,

Trevisiol

Restrepo-Arango³

et al. 2022

Preprint

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“…Portanto, os neurônios perdem a capacidade de estabelecer sinapses com o alvo. Vários fatores parecem inibir a regeneração do Sistema Nervoso Central (SNC), incluindo fatores celulares intrínsecos e extrínsecos (40,41) . Os fatores intrínsecos incluem a ausência ou baixos níveis de certos genes que inibem o crescimento do axônio devido à existência de outros genes no SNC adulto (42) .…”

Section: Epigenética E Terapias Gênicasunclassified

Uso De Sistemas Nanoestruturados No Tratamento Do Câncer

Geraldo¹,

Valencia²

2023

MPJ

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Intensa pesquisa foi deslocada para integrar a nanotecnologia no tratamento do câncer, face aos resultados insatisfatórios das abordagens terapêuticas tradicionais. A nanomedicina, campo sobreposto da nanotecnologia e da medicina, traz uma série de vantagens sobre a terapêutica convencional do câncer, incluindo radiosensibilização, multifuncionalidade, eficiência na entrega de drogas e liberação controlada de agentes quimioterápicos. Dentre as várias frentes de ação que têm sido seguidas, também a terapia gênica surge como uma proposta promissora como suporte ao tratamento do câncer, podendo ainda se aliar a sistemas nanoestrutrados para trazer um efeito sinergético, proporcionando bloqueio de marcadores metastáticos para aumentar a expectativa de vida em pacientes com estadiamento mais avançados.

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Pericyte Biology in the Optic Nerve and Retina

Cited by 2 publications

References 123 publications

Axo-vascular coupling mediated by oligodendrocytes

Axo-vascular coupling mediated by oligodendrocytes

Uso De Sistemas Nanoestruturados No Tratamento Do Câncer

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