Pericytes constrict blood vessels after myocardial ischemia

Costa, Matheus; Paiva, Ana; Andreotti, Julia P.; Cardoso, Marcus Vinicius; Cardoso, Carlos D.; Mintz, Akiva; Birbrair, Alexander

doi:10.1016/j.yjmcc.2018.01.014

Cited by 44 publications

(24 citation statements)

References 52 publications

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“…Despite being the second most abundant cell type in the heart after endothelial cells, pericytes retain similar roles as in the brain, including regulation of angiogenesis, barrier potential and selectivity and regulation of capillary blood flow . As in the brain, constriction of pericytes has been implicated in the context of myocardial infarction where ischaemia causes a powerful constriction to occlude capillaries, which intriguingly can be overcome using intravenous administration of adenosine . Interestingly, cardiac pericytes may also contribute to the origin of a myocardial infarction through their potential involvement in the development of atherosclerosis and vessel stiffening .…”

Section: Pericytes and Capillary Blood Flowmentioning

confidence: 99%

Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Attrill

Ramsay

Ross

et al. 2019

Clin Exp Pharma Physio

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The matching of capillary blood flow to metabolic rate of the cells within organs and tissues is a critical microvascular function which ensures appropriate delivery of hormones and nutrients, and the removal of waste products. This relationship is particularly important in tissues where local metabolism, and hence capillary blood flow, must be regulated to avoid a mismatch between nutrient demand and supply that would compromise normal function. The consequences of a mismatch in microvascular blood flow and metabolism are acutely apparent in the brain and heart, where a sudden cessation of blood flow, for example following an embolism, acutely manifests as stroke or myocardial infarction. Even in more resilient tissues such as skeletal muscle, a short-term mismatch reduces muscle performance and exercise tolerance, and can cause intermittent claudication. In the longer-term, a microvascular-metabolic mismatch in skeletal muscle reduces insulin-mediated muscle glucose uptake, leading to disturbances in whole-body metabolic homeostasis. While the notion that capillary blood flow is fine-tuned to meet cellular metabolism is well accepted, the mechanisms that control this function and where and how different parts of the vascular tree contribute to capillary blood flow regulation remain poorly understood. Here, we discuss the emerging evidence implicating pericytes, mural cells that surround capillaries, as key mediators that match tissue metabolic demand with adequate capillary blood flow in a number of organs, including skeletal muscle. K E Y W O R D Scapillary blood flow, microvasculature, pericytes, skeletal muscle | 521 ATTRILL eT AL.

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Section: Pericytes and Capillary Blood Flowmentioning

confidence: 99%

Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Attrill

Ramsay

Ross

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

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“…Which signaling molecules are needed to activate the extension of pericyte processes into the adjacent endothelial bed? And which signaling molecules are important for these pericytes to reverse the vasodilation that occurs after pericyte death [84]? Although Berthiaume and colleagues have revealed how pericytes respond to the deletion of a neighboring pericyte, they did not explore the molecular and cellular mechanisms involved in this process.…”

Section: Pericyte Communication With Other Tissue Components In Theirmentioning

confidence: 99%

Pericyte Plasticity in the Brain

et al. 2018

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Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using stateof-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain.

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“…Based on those initial criteria, it was suggested that mesenchymal stem cells have a common origin. Due to the broad organ distribution of mesenchymal stem cells, the attention had turned to pericytes as candidates to be the mesenchymal stem cells . Mesenchymal stem cells/pericytes have been shown to be heterogeneous in the skin and differ in their functions as well .…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Macrophage‐derived GPNMB accelerates skin healing

Silva

Prazeres

Paiva

et al. 2018

Experimental Dermatology

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Healing is a vital response important for the re-establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing. Strikingly, transplantation of macrophages expressing GPNMB improves skin healing in GPNMB-mutant mice. Additionally, topical treatment with recombinant GPNMB restored mesenchymal stem cells recruitment and accelerated wound closure in the diabetic skin. From a drug development perspective, this GPNMB is a new candidate for skin healing.

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Pericytes constrict blood vessels after myocardial ischemia

Cited by 44 publications

References 52 publications

Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?

Pericyte Plasticity in the Brain

Macrophage‐derived GPNMB accelerates skin healing

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