Peridinin from the Marine Symbiotic Dinoflagellate, Symbiodinium sp., Regulates Eosinophilia in Mice

Onodera, Kazunari; Konishi, Yuko; Taguchi, Takahiro; Kiyoto, Sumio; Tominaga, Akira

doi:10.3390/md12041773

Cited by 18 publications

(11 citation statements)

References 18 publications

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“…Peridinin and fucoxanthin, carotenoids isolated from Symbiodinium sp., a symbiotic dinoflagellate, and from Petalonia fascia, a brown alga, respectively, were shown to suppress allergic inflammatory responses through the inhibition of delayed-type hypersensitivity in mice, and to reduce the number of eosinophils in both the ear lobe and peripheral blood. The inhibitory effect of peridinin was higher than that of fucoxanthin [144].…”

Section: Cytokine Levels 421 Th2 Cytokinesmentioning

confidence: 76%

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

et al. 2021

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One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications, as well as their sustainability and safety for drug development. Based on the pathobiological features associated with glucocorticoid resistance in severe asthma, many studies have already described many glucocorticoid resistance mechanisms as potential therapeutic targets. On the other hand, in the last decade, many studies described the potentially anti-inflammatory effects of marine-derived biologically active compounds. Analyzing the underlying anti-inflammatory mechanisms of action for these marine-derived biologically active compounds, we observed some of the targeted pathogenic molecular mechanisms similar to those described in glucocorticoid (GC) resistant asthma. This article gathers the marine-derived compounds targeting pathogenic molecular mechanism involved in GC resistant asthma and provides a basis for the development of effective marine-derived drugs.

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Section: Cytokine Levels 421 Th2 Cytokinesmentioning

confidence: 76%

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

et al. 2021

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“…Metabolites 7 and 8 showed 65% and 32% cyclooxygenase-2 inhibition at 2 and 10 μM concentrations, respectively [52,53]. Compound 23 was evaluated basis its ability to suppress delayed-type hypersensitivity in mice [44]. Metabolite 10 has been reported to inhibit L-phosphatidylserine-stimulated protein kinase C activity [54].…”

Section: Biologically Activementioning

confidence: 99%

“…Owing to this property, it is currently used as a fluorescent dye in flow cytometry [80]. e study reported producing this compound in a 132 L culture for more than 40 days [44], with a yield of 24.7 mg (Table 3). However, using the immobilized approach and after 28 days of culture, approximately 1 g of peridinin was produced from the S. voratum CCAC 0047 strain [81].…”

Section: Challenges Related To the Biotechnological Application Ofmentioning

confidence: 99%

Bioactivity and Biotechnological Overview of Naturally Occurring Compounds from the Dinoflagellate Family Symbiodiniaceae: A Systematic Review

Sánchez-Suárez

Garnica-Agudelo

Villamil

et al. 2021

The Scientific World Journal

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Marine invertebrates are a significant source of biologically active compounds. Recent studies have highlighted the role of microbiota associated with marine invertebrates in the production of bioactive compounds. Corals and sponges are the main marine invertebrates producing bioactive substances, and Symbiodiniaceae dinoflagellates are well-recognized endosymbionts with corals and sponges playing vital functions. The biological properties of Symbiodiniaceae-derived compounds have garnered attention in the past decades owing to their ecological implications and potentiality for bioprospecting initiatives. This study aims to systematically review studies on bioactivities and potential biotechnological applications of Symbiodiniaceae-derived compounds. The PRISMA guidelines were followed. Our study showed that anti-inflammatory and vasoconstrictive activities of Symbiodiniaceae-derived compounds have been the most investigated. However, very few studies have been published, with in vitro culturing of Symbiodiniaceae being the most significant challenge. Therefore, we surveyed for the metabolites reported so far, analyzed their chemodiversity, and discussed approaches to overcome culturing-related limitations.

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“…Therefore, they play diverse roles as primary producers, predators, prey, symbiotic partners, and parasites in marine ecosystems (Jeong et al 2010, Holmes et al 2014, LaJeunesse et al 2018. Several dinoflagellate species are known to contain diverse biological materials of economic importance, such as omega-3 fatty acids, macrolides, essential amino acids, carotenoids, and toxins (Shimizu 1996, Mendes et al 2009, Onodera et al 2014, Lim et al 2018. For example, the heterotrophic dinoflagellate Crypthecodinium cohnii is used for commercial DHA production (Mobin and Alam 2017).…”

Section: Introductionmentioning

confidence: 99%

Semi-continuous cultivation of the mixotrophic dinoflagellate Gymnodinium smaydae, a new promising microalga for omega-3 production

Lim¹,

Jeong²,

You³

et al. 2020

ALGAE

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Omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are polyunsaturated fatty acids beneficial to human health. A limited number of microalgae have been used for commercial omega-3 production, which necessitates the identification of new microalgae with high omega-3 contents. We explored the fatty acid composition and EPA and DHA contents of the mixotrophic dinoflagellate Gymnodinium smaydae fed with the optimal algal prey species Heterocapsa rotundata. Cells of G. smaydae were found to be rich in omega-3 fatty acids. In particular, the DHA content of G. smaydae was 21 mg g-1 dry weight, accounting for 43% of the total fatty acid content. The percentage of DHA in the total fatty acid content of G. smaydae was the highest among the reported microalgae except for Crypthecodinium cohnii. Moreover, to determine if the prey supply interval affected the growth rate of G. smaydae and its fatty acid content, three different prey supply intervals (daily, once every 2 d, and once for 4 d) were tested. Daily prey supply yielded the highest total fatty acid and DHA contents in G. smaydae. Furthermore, we successfully produced high-density G. smaydae cultures semi-continuously for 43 d with daily prey supply. During the semi-continuous cultivation period, the highest density of G. smaydae was 57,000 cells mL-1 , with an average growth rate of 0.7 d-1. Taken together, the percentage of EPA and DHA in the total fatty acid content was maintained in the range of 54.2-56.9%. The results of this study support G. smaydae as a promising microalgal candidate for commercial DHA production and demonstrate that daily supply of prey can efficiently produce high-density G. smaydae cultures for more than a month.

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Peridinin from the Marine Symbiotic Dinoflagellate, Symbiodinium sp., Regulates Eosinophilia in Mice

Cited by 18 publications

References 18 publications

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

Bioactivity and Biotechnological Overview of Naturally Occurring Compounds from the Dinoflagellate Family Symbiodiniaceae: A Systematic Review

Semi-continuous cultivation of the mixotrophic dinoflagellate Gymnodinium smaydae, a new promising microalga for omega-3 production

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