Behavior of maintaining denture hygiene is an important factor in the success of denture care. Poor denture hygiene maintenance can cause problems for dental and oral health such as caries, gingivitis, stomatitis, xerostomia, candidiasis, and periodontal disease, especially in users of acrylic-based removable dentures. This study was aimed to obtain the oral hygiene maintenance behavior of denture wearers. This was a literature review study using secondary data sources of the Google Scholar and PubMed databases with keywords, as follows: maintenance behavior, oral hygiene, denture users, acrylic removable partial dentures. Data selection were carried out based on inclusion and exclusion criteria, followed by a critical appraisal. The selection results in six literatures consisting in the form of cross-sectional studies. The results showed that the hygiene behavior of acrylic-based removable dentures in the community was classified as poor. In conclusion, maintenance of oral hygiene behavior of acrylic removable partial denture wearers is classified as poor due to lack of knowledge of most denture wearers to keep their dentures clean.Keywords: maintenance behavior of oral hygiene; denture wearers; acrylic removable partial dentures Abstrak: Perilaku memelihara kebersihan gigi tiruan merupakan faktor penting dalam keberhasilan perawatan gigi tiruan. Pemeliharaan kebersihan gigi tiruan yang kurang baik dapat menimbulkan masalah bagi kesehatan gigi dan mulut seperti karies, gingivitis, stomatitis, xerostomia, kandidiasis, dan penyakit periodontal, terutama pada pengguna gigi tiruan lepasan berbasis akrilik. Penelitian ini bertujuan untuk mengetahui perilaku pemeliharaan kebersihan mulut pengguna gigi tiruan sebagian lepasan (GTSL) akrilik. Jenis penelitian berbentuk literature review dengan menggunakan sumber data sekunder yang diperoleh melalui pencarian database Google Scholar dan PubMed dengan kata kunci: maintenance behavior, oral hygiene, denture users, acrylic removable partial dentures. Seleksi data dilakukan berdasarkan kriteria inklusi dan eksklusi, dilanjutkan dengan critical appraisal. Hasil seleksi mendapatkan enam literatur berbentuk cross-sectional study. Data hasil kajian menunjukkan bahwa perilaku pemeliharaaan kebersihan gigi tiruan lepasan berbasis akrilik pada masyarakat tergolong kurang baik. Simpulan penelitian ini ialah pemeliharaan kebersihan gigi mulut pengguna gigi tiruan sebagian lepasan akrilik masih tergolong kurang baik karena kurangnya kesadaran dan pengetahuan dari sebagian besar masyarakat mengenai pentingnya menjaga kebersihan gigi tiruan.Kata kunci: perilaku pemeliharaan kebersihan mulut; pengguna gigi tiruan; gigi tiruan sebagian lepasan akrilik