Perilla Ketone: A Potent Lung Toxin from the Mint Plant, Perilla frutescens Britton

Abstract

Perilla ketone, from the essential oil of Perilla frutescens, is a potent pulmonary edemagenic agent for laboratory animals and livestock. This finding would account for reported effects of the plant on grazing cattle. The use of perilla in oriental foods and medicinal preparations suggests possible hazards to human health as well.

Antidepressant-Like Effects of Apigenin and 2,4,5-Trimethoxycinnamic Acid from Perilla frutescens in the Forced Swimming Test.

“…[1][2][3][4] One of the goals in our laboratory is to characterize the bioactive compounds of Perilla frutescens. Although many components such as essential oils, 5,6) flavones, 7-9) and phenylpropanoids 10,11) have been identified in Perilla frutescens, to our knowledge, the bioactive compounds for the traditional use of the herbal medicine are still unidentified.In most cases, traditional medicines are prepared by extraction with hot water and are orally administered so that the components present in the aqueous extract may be metabolized by gut flora before being absorbed into the body. Accordingly, to evaluate the bioactive compounds in the herbal medicines, investigation of the compounds actually absorbed into the body is necessary.…”

“…[1][2][3][4] One of the goals in our laboratory is to characterize the bioactive compounds of Perilla frutescens. Although many components such as essential oils, 5,6) flavones, 7-9) and phenylpropanoids 10,11) have been identified in Perilla frutescens, to our knowledge, the bioactive compounds for the traditional use of the herbal medicine are still unidentified.…”

Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses

“…Essential oils from (Studennikova and Khaletskii, 1966;Xu et al, 2001;Wilson et al, 1977;Nagasawa et al, 1969), saponins from Astragali Radix (Yu, 1986), coumarines from Ledebouriellae Radix (Jin et al, 1992), flavonoids from Scutellariae Radix (Takido et al, 1975), phenolic compounds from Moutan Cortex Radicis (Harada and Yamashita, 1969), triterpenoids from Albizziae Cortex (Kinjo et al, 1992), and alkaloids from Adenophorae Radix (Asano et al, 2000) have been previously reported.…”

Recent Progress in One-Pot Syntheses of Fluorinated Building Blocks

“…For example, difluoroanalogue 4 [15] of ar-turmerone is a sesquiterpene displaying an antitumor activity [22]. Difluoroegomaketone with potential bovine respiratory toxicity [25], which contains the moiety of difluoroaldol 6, could be also prepared by using this one-pot methodology [17]. Difluoroegomaketone with potential bovine respiratory toxicity [25], which contains the moiety of difluoroaldol 6, could be also prepared by using this one-pot methodology [17].…”