Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways

Puppala, Eswara Rao; Aochenlar, Sunepjungla L; Shantanu, P. A.; Ahmed, Sahabuddin; Jannu, Arun Kumar; Jala, Aishwarya; Yalamarthi, Sai Sudha; Borkar, Roshan M.; Tripathi, Dinesh Mani; Naidu, V.G.M.

doi:10.1016/j.phymed.2022.154415

Cited by 20 publications

(13 citation statements)

References 30 publications

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“…According to the literature, serum corticosterone levels measured after CRS depend on the time elapsed between the end of the procedure and blood sampling. Indeed, conflicting data are reported with an increase in serum corticosterone level when mice necropsy and blood sampled were performed within 24 h of the end of a CRS [41,[45][46][47][48][49][50][51] and/or preceded by an additional highly stressful forced swim test [18,52]. However, serum level returned to the basal level when necropsy was delayed from the end of CRS [39,43].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Letenneur,

Monnoye,

Philippe

et al. 2023

Nutrients

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The effect of supplementation with Lactobacillus strains to prevent the consequences of chronic stress on anxiety in mouse strains sensitive to stress and the consequences on gut microbiota have been relatively unexplored. Thus, we administered a Lacticaseibacillus casei LA205 and Lacticaseibacillus paracasei LA903 mix to male BALB/cByJrj mice two weeks before and during 21-day chronic restraint stress (CRS) (non-stressed/solvent (NS-PBS), non-stressed/probiotics (NS-Probio), CRS/solvent (S-PBS), CRS/probiotics (S-Probio)). CRS resulted in lower body weight and coat state alteration, which were attenuated by the probiotic mix. S-Probio mice showed less stress-associated anxiety-like behaviours than their NS counterpart, while no difference was seen in PBS mice. Serum corticosterone levels were significantly higher in the S-Probio group than in other groups. In the hippocampus, mRNA expression of dopamine and serotonin transporters was lower in S-Probio than in S-PBS mice. Few differences in bacterial genera proportions were detected, with a lower relative abundance of Alistipes in S-Probio vs. S-PBS. CRS was accompanied by a decrease in the proportion of caecal acetate in S-PBS mice vs. NS-PBS, but not in the intervention groups. These data show that the probiotic mix could contribute to better coping with chronic stress, although the precise bacterial mechanism is still under investigation.

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Section: Discussionmentioning

confidence: 99%

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Letenneur,

Monnoye,

Philippe

et al. 2023

Nutrients

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“…This in turn provides a novel direction for the prevention and treatment of colon cancer. 112 Eswara Rao Puppala et al 113 demonstrated that perillyl alcohol significantly reduced the protein expression of NF-κB, STAT3, and TLR-4 in colon tissues as well as reduced the expression of TNF-α, IL-1β, IL-6, and JAK2. Additionally, it increased the levels of dopamine and 5-HT in the cerebral cortex and HP in dextran sulfate-sodium-induced UC experiments in mice.…”

Section: Effects Of the Chief Essential Oils Components On Ucmentioning

confidence: 99%

“… Reduction of blood pressure elevation in UC rats subjected to repeated stresses [ 140 ] Perillyl alcohol DSS-induced colitis in mice Oral administration for 14 days, 100, 200 mg/kg Perillyl alcohol reverses the TLR4/NF-κB pathway and IL-6/JAK2/STAT3 pathway by inhibiting them in isolated mouse colon and brain Inhibits oxidative stress, inflammatory response. [ 113 ] Nerol A model of oxazolone-induced colitis Oral administration for 7 days, 10, 30, 100, 177.8, 300 mg/kg Reduced IL-13 production, TNF-α activity Prevents stomach damage and has immunomodulatory effects [ 141 ] 1,8-Eucalyptin TNBS induces colitis in rats 200, 400 mg/kg Reduces MPO activity Increased glutathione (GSH) [ 119 ] Ice chips, thymoquinone TNBS induced colitis in rats Oral administration for 15 days of 0.05% thymoquinone (equivalent to an ADI of 75 mg/kg), ice chips - 0.09% and 0.18% (equivalent to 135 mg/kg and 270 mg/kg/day) Reduced concentrations of pro-inflammatory cytokines IL-1β and IL-6 [ 142 ] Olive amygdalin DSS-induced colitis in mice Oral administration for 7 days of 1% olive bittersweet Inhibition of inflammatory cytokines and reduction of COX-2, iNOS, and MMP-9 protein expression in colon tissues NF-κB signaling pathway [ 115 ] Geraniol TNBS induces colitis in rats Oral administration for 11 days, 250 mg/kg Antioxidant, anti-inflammatory, immunosuppressive. Regulation of Wnt/GSK-3β/β-Conjugated Protein, p38MAPK, NF-κB and PPARγ Signaling Pathways [ 100 ] Menthol TNBS induces colitis in rats Oral administration for 3 days, 20, 50, 80 mg/kg Significantly lower levels of IL-1β, IL-6, TNF-α and MPO ...…”

Section: Effects Of the Chief Essential Oils Components On Ucmentioning

confidence: 99%

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

Li,

Zhang,

Luan

et al. 2024

JIR

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Ulcerative colitis (UC) is a chronic non-sp ecific inflammatory disease of the colorectal mucosa. Researchers have associated UC onset with familial genetics, lifestyle behavior, inflammatory immune factors, intestinal microbiota, and the integrity of the intestinal mucosal barrier. The primary therapeutic interventions for UC consist of pharmacological management to control inflammation and promote mucosal healing and surgical interventions. The available drugs effectively control and decelerate the progression of UC in most patients; nonetheless, their long-term administration can exert adverse effects and influence the therapeutic effect. Plant essential oils (EOs) refer to a group of hydrophobic aromatic volatile substances. EOs have garnered considerable attention in both domestic and international research because of their anti-inflammatory, antibacterial, and antioxidant properties. They include peppermint, peppercorns, rosemary, and lavender, among others. Researchers have investigated the role of EOs in medicine and have elucidated their potential to mitigate the detrimental effects of UC through their anti-inflammatory, antioxidant, antidepressant, and anti-insomnia properties as well as their ability to regulate the intestinal flora. Furthermore, EOs exert minimal toxic adverse effects, further enhancing their appeal for therapeutic applications. However, these speculations are based on theoretical experiments, thereby warranting more clinical studies to confirm their effectiveness and safety. In this article, we aim to provide an overview of the advancements in utilizing natural medicine EOs for UC prevention and treatment. We will explore the potential pathogenesis of UC and examine the role of EOs therapy in basic research, quality stability, and management specification of inadequate EOs for UC treatment. We intend to offer novel insights into the use of EOs in UC prevention and management.

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“…↓ NF-κB activation; ↓ p-NF-κB and p-IκBα immunoreactivity [130] Perillaldehyde Human corneal epithelial cell line-HCEC (0.6 mM; 4 h, followed by 8 h stimulation with A. fumigatus)…”

Section: Perillyl Alcoholmentioning

confidence: 99%

“…Most of the studies herein reported assess the effect of monoterpenes on the NF-κB signalling pathway as this transcription factor is the master regulator of inflammation [117]. For instance, carvacrol [118], citral [122], geraniol [126], perillyl alcohol [129,130], thymol [132], among others (Table 5) interfered with the canonical activation of NF-κB, blocking its nuclear translocation and, consequently, its transcriptional activity. On the other hand, some monoterpenes did not interfere directly with NF-κB activation but promoted the activation of other molecules, namely SIRT1 and Nrf2, which antagonize the transcriptional activity of NF-κB [119][120][121]131].…”

Section: Geraniolmentioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways

Cited by 20 publications

References 30 publications

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

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