Perinatal Echovirus Infection: Insights from a Literature Review of 61 Cases of Serious Infection and 16 Outbreaks in Nurseries

Modlin, John F.

doi:10.1093/clinids/8.6.918

Cited by 224 publications

(125 citation statements)

References 30 publications

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“…Prenatal infection of some human enteroviruses has been presumed on the basis of various clinical or virological examinations on neonates (3,4,8,9,11,13). Several researchers reported similarities in the virological properties of both coxsackieviruses and Theiler's virus, and they supposed that the murine virus infection might furnish much information on vertical transmission of the human enteroviruses (10,14).…”

Section: Resultsmentioning

confidence: 99%

“…Several researchers reported similarities in the virological properties of both coxsackieviruses and Theiler's virus, and they supposed that the murine virus infection might furnish much information on vertical transmission of the human enteroviruses (10,14). Transplacental infection of the mouse fetus by the coxsackie B virus has been noted by some reporters (9,11,13). The present experiments elucidated the dose-dependent transplacental transmission of Theiler's virus and the restricted utilization of an animal model for reference in the ecological investigation of coxsackie or echovirus groups, which appeared to induce frequent human natal infection.…”

Section: Resultsmentioning

confidence: 99%

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Dose‐Dependent Transplacental Infection of Murine Encephalomyelitis Virus GDVII in Gravid Uterus

Miyamae

1990

Microbiology and Immunology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dose‐Dependent Transplacental Infection of Murine Encephalomyelitis Virus GDVII in Gravid Uterus

Miyamae

1990

Microbiology and Immunology

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“…the RnA strand is coding (positive) and is embedded into an icosahedral capsid made of 60 copies each of the VP1, VP2, VP3 and VP4 proteins (22). infections with enteroviruses are very common, only second to infections with another group of members of the Picornaviridae family -namely, the rhinoviruses, and may produce a spectrum of clinical outcomes, ranging from asymptomatic infection, to mild upper respiratory illness, to aseptic meningitis, myocarditis, pericarditis, and -in case of neonates and very young children -severe, occasionally fatal disease (13). the role of enteroviral infection in triggering development of diabetes type i in susceptible children is considered to be quite definite (21,30).…”

Section: Basic Features Of Picornaviridae Biologymentioning

confidence: 99%

You Cannot AlwaysWin: Molecular Bases of the Resistance of Picornaviruses to Win Compounds

Mustaffa

Zhelev

2012

Biotechnology & Biotechnological Equipment

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“…Clinical manifestations of neonatal infection with the different EV strains are indistinguishable, with the exception of the polioviruses, which can cause a characteristic transverse myelitis, and coxsackie virus group B, which is usually implicated in cases of EV myocarditis (2). Echovirus serotype 11 and coxsackie virus group B are responsible for a large portion of severe neonatal infections (4,5). The present review focuses on nonpolio EV infections, which are clinically and epidemiologically distinct from disease caused by poliovirus.…”

Section: Virologymentioning

confidence: 99%

Nonpolio enterovirus infection in the neonate and young infant

Hawkes

Vaudry

2005

Paediatrics and Child Health

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MT Hawkes, W Vaudry. Nonpolio enterovirus infection in the neonate and young infant. Paediatr Child Health 2005;10(7):383-388.Nonpolio enterovirus infections are common in the neonatal period, accounting for a large portion of febrile illness during the summer months. Unlike older children and adults, some neonates with enterovirus infection progress to multisystem disease and death. Multiple clinical syndromes of varying severity are associated with neonatal enterovirus infection: asymptomatic viral shedding, nonspecific febrile illness, aseptic meningitis, hepatic necrosis and coagulopathy, and myocarditis. In the present paper, a typical case of neonatal febrile illness is presented and the English-language literature is reviewed with respect to enteroviral infection in early infancy. The virology, epidemiology, transmission, clinical features, diagnosis and treatment of neonatal enteroviral infection are presented. Although the majority of infections in the neonate are benign, timely diagnosis in the febrile neonate will expedite efficient management. Clinicians also need to recognize the clinical manifestations and risk factors for severe disease to anticipate complications and implement intensive management of infants at high risk of adverse outcomes. CASE PRESENTATIONA six-day-old boy presented in June with lethargy and a rash. He was born at term by repeat elective Cesarian section to a 30-year-old G4P3 mother after an uneventful pregnancy. The infant's birth weight was 3625 g and there were no perinatal complications. The mother and infant were discharged home on day 3 of life. On day 6, the infant became lethargic, would not wake for feeding, and had a weak suck and cry. His mother had developed fever, chills and nausea three days postpartum and had noted a rash on her abdomen that spread to her extremities. On examination, the baby had normal vital signs and was afebrile. Pertinent findings were hypotonia, delayed capillary refill time and a maculopapular rash over the trunk. Laboratory investigations revealed a white blood cell (WBC) count of 16.5×10 9 /L, a hemoglobin concentration of 140 g/L and liver enzymes within normal limits. Examination of the cerebrospinal fluid (CSF) revealed a WBC count of 4×10 6 /L, a red blood cell count of 19×10 6 /L, protein of 0.75 g/L and glucose of 2.6 mmol/L. Bacterial cultures of blood, urine and CSF were performed. Empirical antimicrobial therapy was initiated with intravenous ampicillin, gentamicin and acyclovir, and discontinued after five days because all bacterial cultures were negative and the infant was clinically improving. The diagnosis of enteroviral meningitis was confirmed when the CSF viral culture yielded coxsackie virus group B after seven days of incubation. Coxsackie B was also isolated from cultures of stool and nasopharyngeal aspirate. CSF viral polymerase chain reaction (PCR) was not requested at initial sampling, and because the diagnosis was confirmed by viral culture and the infant was improving, a repeat collection was not performed for PC...

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Perinatal Echovirus Infection: Insights from a Literature Review of 61 Cases of Serious Infection and 16 Outbreaks in Nurseries

Cited by 224 publications

References 30 publications

Dose‐Dependent Transplacental Infection of Murine Encephalomyelitis Virus GDVII in Gravid Uterus

Dose‐Dependent Transplacental Infection of Murine Encephalomyelitis Virus GDVII in Gravid Uterus

You Cannot AlwaysWin: Molecular Bases of the Resistance of Picornaviruses to Win Compounds

Nonpolio enterovirus infection in the neonate and young infant

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