Perinatal exposure of pregnant rats to cypermethrin delays testicular descent, impairs fertility in F1 male progeny leading to developmental defects in F2 generation

Singh, Dipty; Bhagat, Sharad; Raijiwala, Paula; Dighe, Vikas; Vanage, Geeta

doi:10.1016/j.chemosphere.2017.06.138

Cited by 19 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…were decreased. It has also been shown to cause atrophy of the seminiferous tubules with decreased spermatocytes and delayed testicular decent 60 in male mice born from exposed mothers.…”

Section: Sperm Qualitymentioning

confidence: 99%

Endocrine‐disrupting chemicals and male reproductive health

Sharma

Mollier

Brocklesby

et al. 2020

Reprod Medicine & Biology

106

View full text Add to dashboard Cite

A number of studies have reported a deterioration in sperm quality over the past 50 years, 1,2 and a variety of factors have been implicated in this decline, including environmental and lifestyle factors. Data from animal and human studies suggest that endocrine-disrupting chemicals are associated in the etiopathogenesis with harmful effects on male reproductive health. 3 Furthermore, recent meta-analysis has suggested that EDCs not only have a deleterious effect on sperm quality but may also be associated with cryptorchidism, hypospadias, and testis cancer, the so-called testicular dysgenesis syndrome. 4 It has been postulated that environmental chemicals may affect the endocrine regulation of fertility since the 1920s. 5 Over the past decade, many chemicals have been observed to have the ability to disrupt the endocrine system and male reproductive health.

show abstract

“…were decreased. It has also been shown to cause atrophy of the seminiferous tubules with decreased spermatocytes and delayed testicular decent 60 in male mice born from exposed mothers.…”

Section: Sperm Qualitymentioning

confidence: 99%

Endocrine‐disrupting chemicals and male reproductive health

Sharma

Mollier

Brocklesby

et al. 2020

Reprod Medicine & Biology

106

View full text Add to dashboard Cite

show abstract

“…Such effects were reported for cis‐bifenthrin in concentration 20 μg/mL, which caused immunotoxic effects in murine macrophages (Wang et al., ), deltametrin, which was reported as a factor that disrupts endocrine and reproductive system of mice in dose 5 mg/kg body weight per day in 35 days of treatment (Ben Slima et al., ). Malfunctions of reproductive and endocrine system were observed in rats exposed to curcumin, quercetin combined with deltamethrin and cypermethrin (in doses 100 mg/kg body weight), as well as cypermethrin itself (1, 2, and 25 mg/kg body weight), impaired reproductive organs and affected fertility in rats (Sharma, Aslam Khan, & Singh, ; Singh, Bhagat, Raijiwala, Dighe, & Vanage, ). Thus essential oils with significant repellent activity against crop pests are interesting alternatives (Bett et al., ).…”

Section: Applicationmentioning

confidence: 99%

Plant‐Derived Substances Used Against Beetles–Pests of Stored Crops and Food–and Their Mode of Action: A Review

Spochacz

Chowański

Walkowiak-Nowicka

et al. 2018

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Plants are sources of numerous active substances that are used to protect crops. Currently, due to the limitations of using synthetic insecticides, plant products have attracted increasing attention as possible pesticides. In this review, we discuss some of the most interesting plant products (for example, Solanaceae, or Asteraceae extracts, Artemisia absinthium or Citrus spp. essential oils, and single compounds like α-chaconine, or α-solanine) that exhibit insecticidal activity against beetles that are pests of stored food products. Next, we describe and discuss the mode of action of these products, including lethal and sublethal effects, such as antifeedant or neurotoxic activity, ultrastructural malformation, and effects on prooxidant/antioxidant balance. Furthermore, the methods of application of plant-derived substances in food storage areas are presented.

show abstract

“…It affects human health adversely by interfering with the endocrine system and referred as endocrine‐disrupting chemicals. Epidemiological and experimental evidences have revealed that exposure to CYP is a key risk factor for Parkinson's disease . Cypermethrin contains 8 optical isomers, with 2 cis diastereomers of cis A (1 R ‐ cis ‐ αR + 1 S ‐ cis ‐ αS ) and cis B (1 S ‐ cis ‐ αR + 1 R ‐ cis ‐ αS ), and 2 trans diastereomers of trans A (1 R ‐ trans ‐ αR + 1 S ‐ trans ‐ αS ) and trans B (1 R ‐ trans ‐ αS + 1 S ‐ trans ‐ αR ).…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological and experimental evidences have revealed that exposure to CYP is a key risk factor for Parkinson's disease. [9][10][11] Cypermethrin contains 8 optical isomers, with 2 cis diastereomers of cisA (1R-cis-αR + 1Scis-αS) and cisB (1S-cis-αR + 1R-cis-αS), and 2 trans diastereomers of transA (1R-trans-αR + 1S-trans-αS) and transB (1R-trans-αS + 1S-trans-αR). Different biological activities were found between these enantiomers.…”

Section: Introductionmentioning

confidence: 99%

Influence of lactic acid bacteria on stereoselective degradation of theta‐cypermethrin

et al. 2017

View full text Add to dashboard Cite

The purpose of this study was to investigate the influence of four kinds of Lactic acid bacteria (LAB) on stereoselective degradation of theta-cypermethrin (CYP), including Lactobacillus plantarum, Lactobacillus casei, Lactobacillus delbrueckii, and Streptococcus thermophilus. An effective analytical method for (±)-theta-CYP in medium was developed by high-performance liquid chromatography with cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase. theta-Cypermethrin was spiked to LAB medium with different inoculation rates and sampled at 0, 2, 8, 24, 36, 48, 72, 120, 168, and 240 hours. The results showed that LAB influenced the half-lives and enantiomer fractions of theta-CYP enantiomers, which lead a closer degradation rate between the 2 stereoisomers, and no obvious difference was found among 4 LABs. Besides, the stereoselective degradation of theta-CYP was closely related to pH. The lower the pH (pH of 3, 5, 7, and 9), the lower the enantiomer fraction (from 4.88 to 6.69). At pH of 3, 7, and 9, significant differences of half-lives between enantiomers were observed. (-)-theta-Cypermethrin decreased faster than (+)-theta-CYP under pH of 3, while opposite results were indicated under pH of 7 and 9. Moreover, the acidic condition contributed to the higher chiral configuration stability of (±)-theta-CYP. (+)-Enantiomer was influenced by pH in a greater degree than (-)-enantiomer.

show abstract

Perinatal exposure of pregnant rats to cypermethrin delays testicular descent, impairs fertility in F1 male progeny leading to developmental defects in F2 generation

Cited by 19 publications

References 21 publications

Endocrine‐disrupting chemicals and male reproductive health

Endocrine‐disrupting chemicals and male reproductive health

Plant‐Derived Substances Used Against Beetles–Pests of Stored Crops and Food–and Their Mode of Action: A Review

Influence of lactic acid bacteria on stereoselective degradation of theta‐cypermethrin

Contact Info

Product

Resources

About