Perinatal maternal negative life events as risk factors of atopic dermatitis in female offspring

Yoon, Jisun; Kim, Eun Mi; Lee, Mi Young; Jung, Sungsu; Cho, Hyun-Ju; Kim, Yeongho; Choi, Yean Jung; Lee, Eun; Yang, Song-I; Lee, So‐Yeon; Lee, Jeong Rim; Yi, Yejin; Hong, Soo‐Jong

doi:10.1016/j.anai.2018.07.020

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…For example, adverse life events assessment in one study 37 used a score by asking participants to select from 27 life events, including separation or divorce, death of a close relative or friend, and financial problems. In another study 35 -7 of 10…”

Section: F I G U R Ementioning

confidence: 95%

“…Main results of the included studies are presented in the Supplementary table (Table S1). Most of these were cohort studies, comprising 20 prospective cohort studies, 7,9,13,14,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] one retrospective cohort study, 36 and one case-control study. 37 The study population comprised individuals from various countries, including Europe, the United States, China, and Australia.…”

Section: Study Characteristicmentioning

confidence: 99%

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Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Ai,

Huang,

Zhu

2024

Clinical & Translational All

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BackgroundThe incidence of atopic dermatitis (AD) in children is increasing. Early exposure to stress factors may be associated with the AD development. This study aimed to summarize studies that reported an association between stress exposure and AD development in later life.Methods and findingsA comprehensive literature search was performed using online databases (PubMed, EMBASE, PsycINFO, and Web of Science) for articles published up to May 1, 2023. Eligible studies were screened and selected based on the inclusion criteria. We incorporated cohort or case‐control studies published in English which explored the relationship between stress experienced by parents or children and AD. The pooled odds ratio (OR) was calculated according to the type of stress using a random‐effects model. Twenty‐two studies were included. AD was related to maternal distress (OR 1.29, 95% Confidence Interval [CI]: 1.13–1.47), maternal anxiety (OR 1.31, 95% CI: 1.18–1.46), and negative life events (OR 2.00, 95% CI: 1.46–2.76). Maternal depression during pregnancy was associated with AD (OR 1.21, 95% CI: 1.09–1.33), whereas no significant association was found for postpartum depression. Research on stress experienced by paternal or children is scare.ConclusionsEarly maternal stress may potentially elevate the risk of AD in their offspring. Importantly, rigorously designed studies are required to corroborate the link between maternal stress and AD in children. These studies should aim to gather insights about the impact of stress during specific trimesters of pregnancy, postnatal stress, and paternal stress, and to identify potential prevention strategies.

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Section: F I G U R Ementioning

confidence: 95%

Section: Study Characteristicmentioning

confidence: 99%

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Ai,

Huang,

Zhu

2024

Clinical & Translational All

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“…18,20 Girls with higher perinatal stress had increased risks of AD compared to that in boys. 21 The gender-specific effects of prenatal PM 2.5 and maternal stress exposure during pregnancy on the offspring's AD and their critical exposure periods remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Kim

Yang

Lim

et al. 2021

Clinical & Translational All

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Background:The prevalence of atopic dermatitis (AD) is increasing worldwide.Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM 2.5 ) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM 2.5 and maternal anxiety on AD and identified the critical period of PM 2.5 exposure for AD in infants. Methods:This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM 2.5 was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.Sangrok Kim and Song-I Yang contributed equally to this work and considered as co-first authors.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…In 2015, AD was associated with almost USD 5.3 billion in health care costs annually in the U.S., placing a significant economic burden on patients and their families [2]. It has previously been suggested that modifiable maternal factors during pregnancy may influence child AD development, including prenatal smoking [3], omega-6 polyunsaturated fatty acid status [4], and maternal stress [5][6][7]. Prenatal maternal stress may play a particularly significant role through increased maternal cortisol production [8][9][10], which modulates fetal immune system development within this crucial offspring developmental window.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have assessed the relationship between prenatal stress and child AD, the majority of which have been conducted in Europe, and findings are not consistent. Positive associations have been reported when defining prenatal stress as high job strain [11], bereavement [5], depression or anxiety [9,12,13], and, most strongly, stressful life events (SLEs) during pregnancy [6,7]. One study found that children whose mothers experienced one or more SLEs during pregnancy versus none had a 53% higher odds (95% confidence interval: 1.11, 2.10) of developing AD [6].…”

Section: Introductionmentioning

confidence: 99%

Maternal Stressful Life Events during Pregnancy and Atopic Dermatitis in Children Aged Approximately 4–6 Years

Senter

Bush

Loftus

et al. 2021

IJERPH

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The prevalence of atopic dermatitis (AD) in children has steadily increased over time, yet it remains largely unknown how maternal factors during pregnancy are associated with child AD. Few studies have specifically assessed the relationship between prenatal stress and child AD, with inconsistent findings. In this prospective cohort study following 426 mother-child dyads from pregnancy to middle childhood, women reported stressful life events (SLEs) experienced during the 12 months before delivery and AD outcomes in children aged approximately 4–6 years, including current, location-specific, and ever AD. We used Poisson regression to estimate risk ratios (RRs) and corresponding 95% confidence intervals (CIs) associated with a 1-unit increase in prenatal SLEs, adjusting for potential confounders. We also assessed whether the association between prenatal SLEs and child AD was modified by child sex, history of maternal atopy, or prenatal maternal resilient coping. The mean (standard deviation) of prenatal SLEs reported in the overall sample was 1.4 (1.6), with 37.1% of women reporting none. A 1-unit increase in prenatal SLEs was not significantly associated with current AD (RR: 1.08, 95% CI: 0.89, 1.31), location-specific AD (RR: 1.09, 95% CI: 0.78, 1.52), or ever AD (RR: 0.97, 95% CI: 0.87, 1.09). We did not find evidence of effect modification. Findings from this study suggest no association between prenatal SLEs and AD in middle childhood, although larger longitudinal studies with enhanced case definition and higher variability of SLE experience may more fully inform this question.

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Perinatal maternal negative life events as risk factors of atopic dermatitis in female offspring

Cited by 5 publications

References 9 publications

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Maternal Stressful Life Events during Pregnancy and Atopic Dermatitis in Children Aged Approximately 4–6 Years

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Perinatal maternal negative life events as risk factors of atopic dermatitis in female offspring

Cited by 5 publications

References 9 publications

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta‐analysis

Prenatal PM2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Maternal Stressful Life Events during Pregnancy and Atopic Dermatitis in Children Aged Approximately 4–6 Years

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Prenatal PM_2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study