Perinatal metabolism of vitamin D

Sallé, Bernard; Delvin, Edgar; Lapillonne, Alexandre; Bishop, Nicholas; Glorieux, Francis H.

doi:10.1093/ajcn/71.5.1317s

Cited by 275 publications

(196 citation statements)

References 61 publications

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“…Previous knowledge about this relationship was based on observational data (24,25) . For example, 25(OH)D in unsupplemented infants born to vitamin D-replete mothers in Finland decreased from~50 nmol/l at birth to <25 nmol/l by 8 weeks of age (25) , a finding that has been interpreted as evidence that the prenatal contribution to infant vitamin D status is limited to the first 2 months of life (16) , consistent with the present trial. Previous trials of maternal supplementation with 10 µg (400 IU) vitamin D daily starting in week 12 of pregnancy until delivery (17) or a bolus dose of 2500 µg (100 000 IU) vitamin D in month 6 or 7 of pregnancy (18) showed significant increases in infant 25(OH)D; however, infant follow-up in those studies was limited to the first week of life.…”

Section: Discussionsupporting

confidence: 89%

Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Perumal

Mahmud

Baqui

et al. 2015

Public Health Nutr.

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Objective: To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine. Design: A prospective observational follow-up of a randomized trial. Setting: Maternal-child health facility in Dhaka, Bangladesh (23°N). Subjects: Infants born to pregnant women (n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D 3 ) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D) was measured at <1, 2, 4 and 6 months of age. Results: Mean infant 25(OH)D was higher in the VD v. PL group at <1 month of age (mean (SD): 80 (20) nmol/l v. 22 (18) nmol/l; P < 0·001), but the difference was attenuated by 2 months (52 (19) nmol/l v. 40 (23) nmol/l; P = 0·05). Groups were similar at 4 months (P = 0·40) and 6 months (n 72; P = 0·26). In the PL group, mean infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v. winter. Conclusions: Prenatal third-trimester vitamin D supplementation (875 µg (35 000 IU)/ week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed infants in this setting.

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Section: Discussionsupporting

confidence: 89%

Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Perumal

Mahmud

Baqui

et al. 2015

Public Health Nutr.

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“…In the absence of environmental and behavioural factors, 25OHD has been found to remain unchanged during pregnancy [7], while other evidence has indicated that 25OHD levels decline slightly with advancing gestation [8]. During pregnancy, 25OHD diffuses across the placental barrier, meaning the foetus relies entirely on the vitamin D status of the mother [9].…”

Section: Introductionmentioning

confidence: 99%

“…Increased synthesis of the active vitamin D form is due to the enhanced production of 1a-hydroxylase in the decidua and placenta, as well as an oestrogen-dependent increase in vitamin D binding protein [7]. This apparent rise in 1,25(OH) 2 D has led to the suggestion that pregnant women may require higher cellular exposure to active vitamin D during the second and third trimesters, and has been interpreted by some as providing evidence for its potential role in obstetric well-being [8].…”

Section: Introductionmentioning

confidence: 99%

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Bennett

McPeake

McCance

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

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Objective: The first aim of this study was to assess 25-hydroxy vitamin D (25OHD) concentrations in women with type 1 diabetes (T1DM) during pregnancy, post-delivery and also foetal (cord blood) 25OHD concentrations and to examine relationships between these. The second aim of the study was to investigate potential interactions between maternal body mass index (BMI) and foetal vitamin D status. A further study aim was to examine potential relationships between maternal 25OHD and glycosylated haemoglobin (HbA 1c ) throughout pregnancy. Research Design and Methods:This was an observational study of 52 pregnant controls without diabetes and 65 pregnant women with T1DM in a university teaching hospital. Maternal serum 25OHD was measured serially throughout the pregnancy and post-delivery. Cord blood 25OHD was measured at delivery. 25OHD was measured by liquid chromatography tandem mass spectrometry (LC-MS/MS).Results: Vitamin D deficiency (25OHD ,25 nmol/L) was apparent in both the T1DM subjects and controls at all 3 pregnancy trimesters. Vitamin D levels in all cord blood were ,50 nmol/L. Maternal 25OHD correlated positively with cord 25OHD at all 3 trimesters in the T1DM group (p = 0.02; p,0.001; p,0.001). 25OHD levels within cord blood were significantly lower for women with diabetes classified as obese vs. normal weight at booking [normal weight BMI ,25 kg/m 2 vs. obese BMI .30 kg/m 2 (nmol/L6SD); 19.93611.15 vs. 13.7364.74, p = 0.026]. In the T1DM group, HbA 1c at booking was significantly negatively correlated with maternal 25OHD at all 3 trimesters (p = 0.004; p = 0.001; p = 0.05). Conclusion:In T1DM pregnancy, low vitamin D levels persist throughout gestation and post-delivery. Cord blood vitamin D levels correlate with those of the mother, and are significantly lower in obese women than in their normal weight counterparts. Maternal vitamin D levels exhibit a significant negative relationship with HbA 1c levels, supporting a potential role for this vitamin in maintaining glycaemic control.

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“…Whole-body mineral content triples between weeks 32-33 and 40-41 of gestation in humans (Salle et al, 2000). Despite this dramatic mineralization, the bones of infants contain more water and less fat, protein, and minerals than adult bones.…”

Section: 36mentioning

confidence: 99%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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Perinatal metabolism of vitamin D

Cited by 275 publications

References 61 publications

Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

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