Perinatal outcome for pregnancies complicated with thrombocytopenia

Onisâi, Minodora; Vlădăreanu, Ana-Maria; Delcea, Caterina; Ciorascu, Mihai; Bumbea, Horia; Nicolescu, Anca; Voican, Irina; Filipescu, Alexandru; Rotaru, Octavian; Vlădăreanu, Radu

doi:10.3109/14767058.2011.648245

Cited by 18 publications

(18 citation statements)

References 21 publications

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“…12,13 Lower incidence was noted in the study of Brohi et al (1.90%) and Lin et al (4.30%). The mean age of patients in present study was 25.74±3.86 years.…”

Section: -11mentioning

confidence: 65%

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Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Chauhan

Gupta

Mahajan

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…12,13 Lower incidence was noted in the study of Brohi et al (1.90%) and Lin et al (4.30%). The mean age of patients in present study was 25.74±3.86 years.…”

Section: -11mentioning

confidence: 65%

“…9,18,19,30 Whereas studies by Parnas et al and Onisai et al showed HELLP syndrome in 12.06% and 9.52% women respectively, which was higher than our study. 13,21 In present study incidence of ITP was 3% amongst pregnant thrombocytopenic women. In the study conducted by Burrows et al incidence was similar to our study (3%) p value -0.945.…”

Section: 17mentioning

confidence: 96%

Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Chauhan

Gupta

Mahajan

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…Onisai et al reported excessive risks related to moderate and severe thrombocytopenia (over twice than reported be-fore) and suggested that preeclampsia and HELLP syndrome were strongly linked with these adverse neonatal outcomes. 17 Furthermore, in this study, a higher incidence of premature and LBW infants was observed when there was moderate to severe thrombocytopenia with preeclampsia, eclampsia, and HELLP syndrome, but none with GT and ITP. The results of the control group were similar to those from the GT group.…”

Section: Discussionmentioning

confidence: 43%

Maternal-Fetal Outcomes of Pregnancies with Thrombocytopenia-One Center Experience

Yener¹,

Ateş²,

Sayın³

et al. 2019

JCOG

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate the etiology, obstetric risk factors, complications, and outcomes of pregnancies affected by thrombocytopenia. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A retrospective surveillance study was conducted based on the hospital records of 1286 women that gave birth during the period between 1 st January 2017 and 31 st December 2018 at the Department of Gynecology and Obstetrics of the Trakya University's School of Medicine. Clinical data including basic history, physical examination, and investigations of women with thrombocytopenia were evaluated. We randomly selected 154 patients without thrombocytopenia that delivered in our clinic during the same period, as the control group, and compared the maternal and fetal outcomes with the thrombocytopenic patient group. R Re es su ul lt ts s: : A total of 154 out of 1286 women (11.9%) had thrombocytopenia of varying severity. Gestational thrombocytopenia (GT) was the most common cause, being identified in 76.2% of the cases with thrombocytopenia. This was followed by preeclampsia (15.5%). About 4.5% of pregnant women with thrombocytopenia were accounted for by idiopathic thrombocytopenic purpura (ITP), 2.5% of the patients by eclampsia, while HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome was observed in 1.3% of the pregnant women with thrombocytopenia. An increased rate of IUGR (Intrauterine growth restriction), fetal distress, and adverse neonatal outcomes were recorded among patients that had thrombocytopenia with preeclampsia, eclampsia, and HELLP syndrome. Furthermore, we observed higher rates of fetal distress and adverse neonatal outcomes in patients with thrombocytopenia compared to the control group. C Co on nc cl lu us si io on n: : GT was the most common cause of thrombocytopenia in pregnancy, followed by preeclampsia. Eclampsia, HELLP syndrome, and ITP were rare causes of this disorder during pregnancy. Early detection and treatment of expected complications are critical for the effective management of such cases.

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“…PE and IUGR are thought to be the consequence of impaired placentation due to an inadequate trophoblastic invasion of the spiral arteries. An imbalance between angiogenic and anti-angiogenic proteins [ 15 , 16 ] and endothelial damage in which platelets may play a role in its pathogenesis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet Count in First Trimester of Pregnancy as a Predictor of Perinatal Outcome

Larroca

Arévalo-Serrano

Abad

et al. 2017

Open Access Maced J Med Sci

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AIM:To rule out maternal and pregnancy factors that may contribute to platelet count (PLT) changes in the first trimester of gestation and examine if there is any association between its levels and adverse perinatal outcome.METHODS:The study population included all patients from the first-trimester visit between 2013-2015 with pregnancy results. Linear multiple regression was constructed to rule out variables that may have a significant contribution to PLT. For each adverse outcome at birth, multiple logistic regression analysis was implemented to estimate the PLT effect.RESULTS:PLT was measured in 6092 patients. There was the significant contribution on PLT in the first trimester from maternal weight, the presence of rheumatologic disease, BHCG levels and MPV. There was a significant association between PLT and abnormal cardiotocography at delivery (OR 1.004; IC95% 1.001 to 1.007) and C-Section due to abnormal CTG (OR 1.005; IC95% 1.002 to 1.008). When adjusted for factors that interact with PLT there was also a significant association with pH at birth < 7.10 and gestational diabetes.CONCLUSIONS:Maternal and pregnancy factors can poorly predict relevant changes in PLT at the first trimester of gestation. PLT at first trimester of pregnancy might predict adverse perinatal outcome in combination with other markers.

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Perinatal outcome for pregnancies complicated with thrombocytopenia

Cited by 18 publications

References 21 publications

Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Maternal and fetal outcome among pregnant women presenting with thrombocytopenia

Maternal-Fetal Outcomes of Pregnancies with Thrombocytopenia-One Center Experience

Platelet Count in First Trimester of Pregnancy as a Predictor of Perinatal Outcome

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