Perinatal Outcome of Twin Pregnancies After IVF/ICSI

Han, Wei; Kühne, S. M.; Seufert, R.; Tong, Xiao-Mei; Fischl, Franz; Kölbl, H.

doi:10.1055/s-0029-1185354

Cited by 3 publications

(8 citation statements)

References 13 publications

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“…In comparison to the published literature, we found confirming data regarding higher maternal age in ART twins [8,17,[25][26][27]30]. Only the study of Han et al [16] observed no evidence for increased maternal age in ART twins. Similarly, a higher rate of primiparity and pre-eclampsia was previously described to be present in twins born after ART, respectively only IVF [6,8,12,16,17,26].…”

Section: Maternal Age Primiparity Pre-eclampsiasupporting

confidence: 89%

“…In addition, the rate of Caesarean section observed in another German study differs markedly between ART (76.2 %) and SC (42.5 %) twins [16]. It is possible that regional differences as well as selective patient admission policies play a role in causing the discrepancies to our data [16]. Over the last decade, the rates of Caesarean section in Germany generally increased to 31 % in 2008 (Statistisches Bundesamt, 2008) [35].…”

Section: Caesarean Sectionmentioning

confidence: 88%

“…Only the study of Han et al [16] observed no evidence for increased maternal age in ART twins. Similarly, a higher rate of primiparity and pre-eclampsia was previously described to be present in twins born after ART, respectively only IVF [6,8,12,16,17,26]. We assume that all three phenomena are due to social and health-related issues of elder women and do not reflect intrinsic issues related to ART.…”

Section: Maternal Age Primiparity Pre-eclampsiamentioning

confidence: 93%

“…One study described a higher rate of elective surgical delivery [44], and three other studies report a higher rate of Caesarean section, in addition to prematurity and prematurity-related neonatal complications for ART twins [4,20,25]. In addition, the rate of Caesarean section observed in another German study differs markedly between ART (76.2 %) and SC (42.5 %) twins [16]. It is possible that regional differences as well as selective patient admission policies play a role in causing the discrepancies to our data [16].…”

Section: Caesarean Sectionmentioning

confidence: 98%

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Twin Pregnancies Conceived Spontaneously and by ART (Assisted Reproductive Technologies) – a Retrospective Analysis and Review

Lehnen¹,

Schäfer²,

Reineke³

et al. 2011

Geburtsh Frauenheilk

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Purpose: The aim of this study was to compare the perinatal and maternal outcome of our own cohort of twin pregnancies after IVF/ICSI and spontaneous conception to the respective available standards and findings in the current literature. Material and Methods: Perinatal and maternal data of 305 twin pregnancies conceived spontaneously and 74 pregnancies conceived by IVF/ICSI were compared. The following parameters were examined: maternal age, first parity, gestational age, Caesarean section rate, birth weight, sex constellation, umbilical arterial blood pH of the first and second child, maternal complications, fetal malformations, perinatal and neonatal mortality. These data were tested by retrospective statistical analysis (Fisher exact test, Wilcoxon Rank Sum Test). In addition, these parameters were also evaluated separately in dichorionic/diamniotic twins and monochorionic/diamniotic twins. Results: We found significant differences with higher maternal age, higher rate of first parity, an increased incidence of pre-eclampsia and a lower rate of SGA (VLBW) in the ART group and ART subgroup (di/di) compared to the SC group. Caesarean section rate, birth weight, arterial pH of the first and second twin, prematurity, rate of malformations, perinatal and neonate mortality, respectively, were not significantly different between the two groups. For prematurity < 37 weeks of gestation, a significantly higher frequency of the male/male sex constellation was observed. Conclusion: Actually, we are now able to more specifically counsel women conceiving by IVF/ICSI concerning maternal and perinatal outcome. Zusammenfassung! Fragestellung: Ziel der Studie ist der Vergleich zwischen dem perinatologischen und maternalen Outcome unserer eigenen Zwillingsschafts-Kohorte nach ART (IVF/ICSI) und spontaner Konzeption (SC) im Vergleich zu den verfügbaren Standards und Suchergebnissen der vorhandenen Literatur. Material und Methoden: Verglichen wurden die perinatalen und maternalen Daten von 305 spontan konzipierten Zwillingsschwangerschaften zu 74 Geminigraviditäten nach IVF/ICSI. Die folgenden Parameter wurden untersucht: mütterliches Alter, Erstparität, Schwangerschaftwoche, Sectiorate, Geburtsgewicht, Geschlechtskonstellation, arterieller Nabelschnur-pH des 1. und 2. Kindes, maternale Komplikationen, fetale Fehlbildung, perinatale und neonatale Mortalität. Diese Daten wurden einer retrospektiven statistischen Analyse mittels Fisher-Exact-Test, Wilcoxon-Rangsummen-Test unterzogen. Weiterhin wurden diese Daten nach Dichorializität/Diamnializität und Monochorializität/Biamnializität aufgeschlüsselt. Ergebnisse: Wir fanden signifikante Differenzen mit höherem maternalen Alter, höherer Rate von Erstparität und einer ansteigenden Inzidenz von Präeklampsie sowie eine niedrigere Rate von SGA (VLBL) in der ART-Gesamtgruppe und ART-Subgruppe (Dichorializität/Diamnializität) im Vergleich zur SC-Gruppe. Die Sectiorate, das Geburtsgewicht, der umbilikale arterielle pH des 1. und 2. Zwillings, Frühgeburtlichkeit, Malformationsrate, perinatal...

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Section: Maternal Age Primiparity Pre-eclampsiasupporting

confidence: 89%

Section: Caesarean Sectionmentioning

confidence: 88%

Section: Maternal Age Primiparity Pre-eclampsiamentioning

confidence: 93%

Section: Caesarean Sectionmentioning

confidence: 98%

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Twin Pregnancies Conceived Spontaneously and by ART (Assisted Reproductive Technologies) – a Retrospective Analysis and Review

Lehnen¹,

Schäfer²,

Reineke³

et al. 2011

Geburtsh Frauenheilk

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“…In the United States, twin deliveries increased by 62 % for Caucasians from 1975 to 2000, with the largest increase occurring in the year 2000, affirming the topicality and significance of the issue of twin pregnancy [1,2]. In Switzerland, twin births have risen by more than 50 % since 1980, which in part is ascribable to the augmented use of assisted reproductive technologies and the rise in average maternal age when pregnant [3]. In 2004 the incidence of multiple births in Switzerland accounted for 1.7 % of all births, with 94 % of these twin births [4].…”

mentioning

confidence: 99%

New Reference Curves on Maternal Weight Gain in Twin Pregnancy

Böhni¹,

Roos²,

Kurmanavičius³

et al. 2011

Geburtsh Frauenheilk

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Purpose: Aim of the study was to generate reliable weight reference curves on maternal weight gain in twin pregnancy and to compare them to previous studies. Methods: A retrospective mixed model analysis was done at the Obstetric Outpatient Clinic of Zurich University Hospital to evaluate data gathered from 1/2004 to 4/2008. Maternal weight and BMI, before gestation and at the booking visit, as well as the infant birth weight were determined in 245 accurately dateable twin pregnancies of Caucasian women. 5th, 50th and 95th percentiles were presented and simple and multiple regression analyses were performed for various risk factors. Results: Mean weight gain was 19.1 kg at 37 gestational weeks with values of 29.2 kg and 9.1 kg for the 95th and the 5th percentile, respectively. Maternal weight gain at delivery was found to have a significant impact on infant birth weight. If maternal weight gain at delivery increased by 1 kg, then the mean weight of both twins increased by 80 g. Discussion/Conclusions: The presented reference curves on maternal weight gain may be helpful in counseling women with a twin pregnancy -they may reduce the risks arising from low or high maternal weight gain and help to prevent maternal long-term obesity.Zusammenfassung ! Ziele: Erstellung neuer, verlässlicher und leicht anwendbarer Normkurven für die mütterliche Gewichtszunahme in Zwillingsschwangerschaften und Vergleich der Ergebnisse mit Resultaten internationaler Studien. Material und Methoden: Es wurde eine retrospektive Mixed-Model-Analyse durchgeführt, worin Daten der Klinik für Geburtshilfe des Zür-cher Universitätsspitals vom 1/2004 bis 4/2008 ausgewertet wurden. Bei 245 Kaukasierinnen mit genau datierbaren Zwillingsschwangerschaften wurden die mütterliche Gewichtszunahme und BMI, vor der Schwangerschaft und am Termin, sowie die kindlichen Geburtsgewichte bestimmt. Die 5., 50. und 95. Perzentile für die müt-terliche Gewichtszunahme wurden erstellt und simple und multiple Regressionsanalysen für verschiedene Risikofaktoren durchgeführt. Resultate: Die mittlere Gewichtszunahme bei 37 Schwangerschaftswochen lag bei 19,1 kg mit Werten von 29,2 und 9,1 kg für die 95. bzw. 5. Perzentile. Die mütterliche Gewichtszunahme bei Geburt zeigte einen signifikanten Einfluss auf das kindliche Geburtsgewicht. Sobald die mütterliche Gewichtszunahme um 1 kg anstieg, erhöhte sich das mittlere Gewicht beider Zwillinge um 80 g. Schlussfolgerungen: Die präsentierten Normkurven für die mütterliche Gewichtszunahme kön-nen ein hilfreiches Instrument in der Betreuung von Zwillingsschwangerschaften sein -mütter-liche und kindliche Risiken, bedingt durch eine zu geringe oder zu große Gewichtszunahme, kön-nen möglicherweise vermindert und ein nachteiliges "fetal programming" und eine schwangerschaftserworbene Adipositas bei extremen Gewichtszunahmen verhindert werden.

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Recent Trends in the Incidence of Multiple Births and Its Consequences on Perinatal Problems in Korea

et al. 2010

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The aim of this study was to survey multiple birth data and to analyze the recent trends of multiple births and its consequences on perinatal problems in Korea from 1991 to 2008. Data were obtained from the Korean Statistical Information Service. The total number of multiple births showed increasing trends. The multiple birth rate was maintained within less than 10.0 for the decade from 1981 to 1990. However, it increased gradually to reach 27.5 in 2008. The maternal age for multiple births was higher than for total live births. The mean birth weight of the total live births was 3.23 kg; for the multiple births it was 2.40 kg in 2008. The incidence of low birth weight infants (LBWI) among total live births was 3.8% in 2000 and 4.9% in 2008. For multiple births it was 49.2% and 53.0% during the same years. The incidence of preterm births among total live births was 3.8% in 2000 and 5.5% in 2008; for the multiple births it was 38.3% and 51.5% during the same years. The incidence of multiple births and its consequences on perinatal problems (preterm, LBWI, and advanced-maternal age) have been increased steadily over the last two decades in Korea.

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Perinatal Outcome of Twin Pregnancies After IVF/ICSI

Cited by 3 publications

References 13 publications

Twin Pregnancies Conceived Spontaneously and by ART (Assisted Reproductive Technologies) – a Retrospective Analysis and Review

Twin Pregnancies Conceived Spontaneously and by ART (Assisted Reproductive Technologies) – a Retrospective Analysis and Review

New Reference Curves on Maternal Weight Gain in Twin Pregnancy

Recent Trends in the Incidence of Multiple Births and Its Consequences on Perinatal Problems in Korea

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