Perinatal photoperiod imprints the circadian clock

Ciarleglio, Christopher M.; Axley, John C.; Strauss, Benjamin R; Gamble, Karen L.; McMahon, Douglas G.

doi:10.1038/nn.2699

Cited by 132 publications

(132 citation statements)

References 15 publications

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“…The current findings indirectly support the hypothesis that early life exposure to light may affect the long-term adaptive responses of the circadian system (Erren et al, 2011;Ciarleglio et al, 2011;Brooks and Canal, 2013). We previously found that the greater the springtime increase in solar insolation at the onset location, the younger the age of onset of bipolar disorder, especially for those with a family history of mood disorders.…”

Section: Discussionsupporting

confidence: 87%

“…It was postulated that exposure to light during early life imprints an individual's circadian clock, setting vulnerability to future environmental challenges to the circadian system (Ciarleglio et al, 2011;Erren et al, 2011). We previously found that the larger the springtime increase in solar insolation at the onset location, the younger the age of onset of bipolar I disorder, especially for those with a family history of mood disorders (Bauer et al, 2012;Bauer et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

“…At birth, the human circadian system is still immature and developing, and the physical environment may influence its maturation by means of complex epigenetic mechanisms (Azzi et al, 2014;Brooks and Canal, 2013;Ciarleglio et al, 2011;Gluckman et al, 2005;Masri and Sassone-Corsi, 2010;Rivkees, 2007). It was postulated that exposure to light during early life imprints an individual's circadian clock, setting vulnerability to future environmental challenges to the circadian system (Ciarleglio et al, 2011;Erren et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Influence of light exposure during early life on the age of onset of bipolar disorder

Bauer

Glenn²,

Alda

et al. 2015

Journal of Psychiatric Research

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of light exposure during early life on the age of onset of bipolar disorder

Bauer

Glenn²,

Alda

et al. 2015

Journal of Psychiatric Research

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“…For example, it is well known that photoperiodic information can be transmitted in utero via maternal melatonin secretion, and this prenatal signal can affect postnatal photoperiodic responses (Horton 1985, Stetson et al 1986, Lee et al 1987, Weaver et al 1987, Elliott & Goldman 1989) and the reproductive development of young (Prendergast et al 2000, Kauffman & Zucker 2002, Tuthill et al 2005. More recent studies have shown that perinatal photoperiod can have lasting effects on circadian rhythms expressed by clock neurons, wheel-running behavior (Ciarleglio et al 2011), depressive-and anxiety-like behaviors , and immune responses (Weil et al 2006). Finally, pilot studies in our laboratory of very young (3-week-old) hamsters gestated and held in LD or SD have demonstrated photoperiod-dependent changes in ovarian gene expression in the absence of morphological or histological differences.…”

Section: Gonadotropin Suppression In Ldsmentioning

confidence: 99%

Photoperiod-gonadotropin mismatches induced by treatment with acyline or FSH in Siberian hamsters: impacts on ovarian structure and function

et al. 2012

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Many seasonal breeders time their reproductive efforts to specific times of the year to ensure adequate resources for the production and care of young. For long-day (LD) breeders, females born before the summer solstice (LDs) reach sexual maturity quickly and often breed that same year, whereas females born after the summer solstice (short days (SDs)) may delay reproductive development to the following spring when environmental conditions are favorable for reproduction. In Siberian hamsters, development in SD is associated with structural and functional differences in the ovary compared with females held in LD, including a greater number of primordial follicles and an abundance of hypertrophied granulosa cells (HGCs), which are immunoreactive for anti-Mü llerian hormone. The goal of this study was to determine whether SD-induced gonadotropin suppression is responsible for these phenotypic differences. Gonadotropin levels were suppressed in LD hamsters using the GNRH antagonist acyline. Conversely, to determine whether the SD ovarian phenotype is completely reversed by gonadotropin stimulation, recombinant human FSH (rhFSH) was administered. Our treatments were successful in mimicking FSH concentrations of the opposite photoperiod, but they did not produce a comparable change in the ovarian phenotype. Most notable was the lack of HGCs in the ovaries of acyline-treated LD females. Similarly, HGCs were maintained in the ovaries of SD females treated with rhFSH. Our data suggest that gonadotropins alone do not account for the SD ovarian phenotype. Future studies will determine whether SD-induced changes in other factors underlie these phenotypic changes.

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“…The annual shortening of the photoperiod is believed to be the main factor in SAD onset; however, responses to cold temperatures and epigenetic changes have been documented in seasonal mammals and exhibit evolutionary conservation down to lower forms of life [3][4][5][6] , suggesting that many very basic physiologic mechanisms could contribute to SAD. Ultimately, SAD is a complex disease with both chronobiological and neurobiological underpinnings [7][8][9][10][11] , which may include an etiology that for some could even begin in utero [12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Normalizing sleep quality disturbed by psychiatric polypharmacy and sleep apnea: a comprehensive patient-centered N-of-1 study

Magnuson¹,

Yan-pin²,

Schork³

2016

F1000Res

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There is a growing interest in personalized and preventive medicine initiatives that leverage serious patient engagement, such as those initiated and pursued among participants in the quantified-self movement. However, many of the self-assessments that result are not rooted in good scientific practices, such as exploiting controls, dose escalation strategies, multiple endpoint monitoring, etc. Areas where individual monitoring and health assessments have great potential involve sleep and behavior, as there are a number of very problematic sleep and behavior-related conditions that are hard to treat without personalization. For example, winter depression or seasonal affective disorder (SAD) is a serious, recurrent, atypical depressive disorder impacting millions each year. In order to prevent yearly recurrence antidepressant drugs are used to prophylactically treat SAD. In turn, these antidepressant drugs can affect sleep patterns, further exacerbating the condition. Because of this, possibly unique combinatorial or 'polypharmaceutical' interventions involving sleep aids may be prescribed. However, little research into the effects of such polypharmacy on the long-term sleep quality of treated individuals has been pursued. Employing wireless monitoring in a patient-centered study we sought to gain insight into the influence of polypharmacy on sleep patterns and the optimal course of therapy for an individual being treated for SAD with duloxetine (Cymbalta) and temazepam. We analyzed continuous-time sleep data while dosages and combinations of these agents were varied. We found that the administration of Cymbalta led to an exacerbation of the subject's symptoms in a statistically significant way. Further, we unmasked and monitored treatment effects on a latent obstructive sleep apnea condition. We argue that such analyses may be necessary to effectively treat individuals with similar overall clinical manifestations and diagnosis, despite their having a unique set of symptoms, genetic profiles and exposure histories. We also consider the limitations of our study and areas for further research.

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Perinatal photoperiod imprints the circadian clock

Cited by 132 publications

References 15 publications

Influence of light exposure during early life on the age of onset of bipolar disorder

Influence of light exposure during early life on the age of onset of bipolar disorder

Photoperiod-gonadotropin mismatches induced by treatment with acyline or FSH in Siberian hamsters: impacts on ovarian structure and function

Normalizing sleep quality disturbed by psychiatric polypharmacy and sleep apnea: a comprehensive patient-centered N-of-1 study

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