Perinatal Risk Factors for Neonatal Early-onset Group B Streptococcal Sepsis after Initiation of Risk-based Maternal Intrapartum Antibiotic Prophylaxis—A Case Control Study

Santhanam, Sridhar; Arun, Sumita; Rebekah, Grace; Ponmudi, Nithya; Chandran, Jolly; Jose, Ruby; Jana, Atanu Kumar

doi:10.1093/tropej/fmx068

Cited by 24 publications

(38 citation statements)

References 7 publications

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“…Neonates delivered from women with meconium stained amniotic fluid were nearly four times more likely to develop sepsis compared with those without. This is consistent with studies conducted in Mexico (2012), Ghana(2014), South Africa (2012), India (2017), Nepal and Indonesia (2015) [6,9,10,25,30,31]. This might be due to the fact that neonates delivered from women with meconium stained amniotic fluid are more liable to aspirate it and fill smaller air ways and alveoli in the lung.…”

Section: Discussionsupporting

confidence: 88%

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Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study

et al. 2020

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Background Despite remarkable progress in the reduction of death in under-five children, neonatal mortality has shown little or no concomitant reduction globally. It is also one of the most common causes of neonatal death in Ethiopia. Little is known on predictors of neonatal sepsis. Risk based screening and commencement of treatment appreciably reduces neonatal death and illness. Therefore, the main aim of this study was to identify predictors of neonatal sepsis in public referral hospitals of Northwest Ethiopia. Methods Institutional based unmatched case-control study was conducted among a total of 231 neonates in Debre Markos and Felege Hiwot referral hospitals from March 2018-April 2018. Neonates who fulfill the preseted criteria for sepsis were considered as cases and neonates diagnosed with other medical reasons except sepsis were controls. For each case, two consecutive controls were selected by simple random sampling method. Data were collected using structured pretested questionnaire through a face to face interview with index mothers and by reviewing neonatal record using checklist. The collected data were entered into Epi data version 3.1 and exported to STATA/ SE software version 14. Binary and multivariable logistic regression analyses were employed. Statistical significance was declared at P<0.05. Result Multivariable logistic regression analysis showed that, duration of rupture of membrane � 18hours was significantly associated with sepsis (AOR = 10.4, 95%CI = 2.3-46.5). The other independent predictors of neonatal sepsis were number of maternal antenatal care service �3 (

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Section: Discussionsupporting

confidence: 88%

“…Maternal factors such as intra-partum fever, instrumental delivery and place delivery are significant predictors of neonatal sepsis. Neonates born from women with more than three times digital per vaginal examination and never attend antenatal care (ANC) are at higher risk for neonatal sepsis [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study

et al. 2020

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“…The risk of EOGBS reduces with the use of intrapartum antibiotic prophylaxis (IAP) 7. There are two approaches for GBS screening and IAP: risk-based screening strategy and universal culture-based screening strategy 8.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and current practices of pregnant women towards group B streptococcus screening: cross-sectional study, Al-Madinah, Saudi Arabia

et al. 2020

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AimsGroup B streptococcus (GBS) is one of the most frequent bacterial pathogens causing invasive infections in neonates. It can be transmitted from colonised mother to neonates around delivery. Screening strategies for GBS during pregnancy include either universal culture-based or risk-based screening. The present study aimed to assess the knowledge, attitude and current practices of pregnant women towards GBS screening in Al-Madinah City, Saudi Arabia.MethodsA hospital-based cross-sectional study was conducted at Madinah Maternity and Children Hospital, Al-Madinah, Saudi Arabia, from May to July 2018. Participants were recruited from postnatal wards. Participants were interviewed using a previously published validated survey that was divided into the following domains: demographic data, knowledge, experience and attitude towards different GBS screening strategies.ResultsA total of 377 out of 450 women (response rate 83.7%) were enrolled. The results showed that the overall mean knowledge score of the pregnant women towards GBS screening was 59.8%. Majority of the women (66.8%) were not aware of the GBS bacterium, while 86.5% of them had never been informed of GBS risk assessment during their pregnancies. The mean knowledge score among women who were aware of GBS (62.8%) was significantly higher than that among women who were not (58.4%) (p=0.015). However, majority of the pregnant women (61.8%) showed preference for universal culture-based GBS screening strategy over risk-based strategy.ConclusionThe study results have concluded that the level of awareness and knowledge about GBS among pregnant women were relatively poor; however, majority of the pregnant women prefer universal culture-based screening.

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“…health challenge (4). As documented in different literatures, neonatal sepsis is caused by factors related to both maternal and neonatal factors such as prolonged rupture of membrane (PROM),, urinary tract infection, intrapartum fever, instrumental delivery,prematurity, chorioamnionitis, frequent vaginal examination, never attend antenatal care (ANC), home delivery, meconium-stained amniotic fluid, contaminated foods intake, low birth weight, complicated or instrument-assisted delivery, low appearance pulse grimace activity respiration (APGAR) scores and invasive procedures during hospital admission (5)(6)(7)(8)(9)(10)(11). Guidelines for the treatment of neonatal sepsis have been formulated and its implementation along with timely initiation of better treatments would satisfactorily decrease morbidity and mortality of neonates by sepsis (3).…”

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confidence: 99%

Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis, 2019

Beletew

Kassie

Kassaw

et al. 2019

Preprint

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Background: Neonatal sepsis is one of the most leading causes of inflated death and illness of neonates. Different primary studies in Eastern Africa showed the burden of neonatal sepsis. However, inconsistency among those studies was seen and no review has been conducted to report the amalgamated magnitude and associated factors. Therefore, this review aimed to estimate the national prevalence and associated factors of neonatal sepsis in Eastern Africa. Methods: Using PRISMA guideline, we systematically reviewed and meta-analyzed studies that examined the prevalence and associated factors of neonatal sepsis from PubMed, Cochrane library, and Google Scholar. Heterogeneity across the studies was evaluated using the Q and the I2 test. A weighted inverse variance random-effects model was applied to estimate the national prevalence and the effect size of associated factors. The subgroup analysis was conducted by country, study design, and year of publication. A funnel plot and Egger’s regression test were used to see publication bias. Result: A total of 26 studies with 11239 participants were used for analysis. The pooled prevalence of neonatal sepsis in East Africa was 29.65% (95% CI; 23.36–35.94).Home delivery(AOR =2.67; 95% CI: 1.15-4.00; I2= 0.0%; P=0.996), maternal history of UTI (AOR=2.083; 95% CI :0.24-3.93; I2= 69.1%; P=0.001),gestational age (preterm) (AOR=1.56; 95% CI: 1.04-2.08; I2= 27.8%;P=0.000) ,prolonged labor (AOR=3.23 ;95% CI: -0.04-6.51; I2= 62.7%; P=0.020) and PROM (AOR= 1.95; 95% CI: 0.53-3.37; I2= 43.2%; P=0.062) were identified factors of neonatal sepsis. Conclusions: The prevalence of neonatal sepsis in Eastern Africa remains high. This review may help policy-makers and program officers to design neonatal sepsis preventive interventions. Keywords: Neonatal sepsis, Eastern Africa

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Perinatal Risk Factors for Neonatal Early-onset Group B Streptococcal Sepsis after Initiation of Risk-based Maternal Intrapartum Antibiotic Prophylaxis—A Case Control Study

Cited by 24 publications

References 7 publications

Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study

Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study

Knowledge, attitude and current practices of pregnant women towards group B streptococcus screening: cross-sectional study, Al-Madinah, Saudi Arabia

Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis, 2019

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