Perinatal winter conditions affect later reproductive performance in romanian women: Intra and intergenerational effects

Huber, Susanne; Fieder, Martin

doi:10.1002/ajhb.21184

Cited by 12 publications

(7 citation statements)

References 34 publications

(37 reference statements)

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“…The seasonal effects of natural factors have been extensively studied. The target populations are spread all around the world (Lam and Miron, 1994;Martinez-Bakker et al, 2014;Friger et al, 2009;Dorélien, 2013;Hubert, 2014), but very rarely were they focused on Romania (except for Huber and Fieder, 2011). The findings on climate effects vary across time and geographical location.…”

Section: Introductionmentioning

confidence: 99%

“…They have been extensively analyzed, the importance attributed to them ranging from high (Villerme, 1831) to as unimportant in e.g. some French population (Regnier-Loilier and Rohrbasser, 2011) or seen as acting jointly with economic development (Huber and Fieder, 2011;Seiver, 1985) due to the reasoning that poor populations are negatively affected by low temperatures during winter or, on the contrary, by hot summers without air conditioning. Other researchers (Macfarlane, 1974;Lam and Miron, 1994) stated that weather affects the seasonality of births as long as there are major temperature differences over the year.…”

Section: Introductionmentioning

confidence: 99%

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Effect of religious rules on time of conception in Romania from 1905 to 2001

et al. 2015

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B.V.I., M.A. and G.R. have no competing interests to declare. There is no connection to the current paper, but C.H. declares that (i) he is currently conducting a research titled 'Chronic Diseases' Direct Costs within the Romanian Health System' funded by Local American Working Group; (ii) his wife is employed to a Romanian company (A&D Pharma) that does business in the pharmaceutical sector. This paper is a part of G.R. and M.A. scientific activities in COST Action TD1210. This work by C.H. was co-financed by the European Social Fund through project number POSDRU/1.5/S/59184.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of religious rules on time of conception in Romania from 1905 to 2001

et al. 2015

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“…Significant factors in the full model ( Table 2 ) demonstrate the importance of other factors (e.g., BMI) and their interactions with environmental factors (BMI and air pollution) on female fertility and birth rate on a global scale. This is important because many of these factors correlate with temperature indicating that earlier work seeking to demonstrate a relationship between perinatal exposure of females to high temperatures decreases female fertility later in life may be capturing an environmental exposure that is coupled with temperature, but not temperature itself [ 2 , 3 , 10 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…This hypothesis was supported by the results from studies conducted in Austria [ 3 ], New Zealand [ 10 ] and NYC [ 2 ]. However, results from Vietnam [ 11 ] and Romania [ 12 ] appeared to find the opposite result, namely females born in high heat environments had increased fertility. This reveals an incomplete understanding regarding the relationship between seasonal temperature variation and female fertility/fecundity later in life.…”

Section: Introductionmentioning

confidence: 99%

A model investigating environmental factors that play a role in female fecundity or birth rate

Boland

2018

PLoS ONE

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ObjectiveOver 12% of women in the United States have reduced fertility and/or fecundity. Environmental factors, such as temperature, and socioeconomic factors have been implicated in reducing female fecundity. The purpose of this study is to investigate the effect of environmental factors coupled with socioeconomic factors on birth rate at the country-level. We use birth rate as a proxy for female fecundity. This will enable us to identify the most important factors affecting female fecundity.MethodsUsing country-specific data from 182 countries, we constructed a regression model of the effects of environmental and socioeconomic factors on birth rate at the country-level. Our model assesses the role of temperature, Gross Domestic Product (GDP) per capita, fine air particulate matter (PM 2.5), and prevalence of male and female Body Mass Index (BMI) > = 25 (age-standardized) on birth rate per country. Because many of these factors are inter-dependent, we include all possible two-way interaction terms to assess the role of individual factors and interactions between multiple factors in the model.ResultsIn the full regression model, we found that GDP per capita along with 5 interaction terms were significant after adjusting for multiple testing. Female BMI was only nominally significant. GDP per capita was independently associated with birth rate (adjusted p-value <0.001). Prevalence of BMI > = 25 age-standardized in males and females were also significant when interacting with air pollution or GDP on female fecundity (birth rate). Temperature did not affect birth rate either independently or as an interaction unless BMI was removed from the model.ConclusionA country’s economic wealth was the most significant factor in predicting birth rate in a statistical model that includes environmental and socioeconomic variables. This is important for future studies investigating environmental factors involved in increasing or decreasing female fecundity.

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“…2 and 3 represent the 'relative risk' of having a baby by birth month. The other 7 studies included in this meta-analysis were the result of Huber et al 8,[32][33][34][35] . In the Huber et al studies the results are the average number of live-born children per woman by birth month.…”

Section: Meta-analysis Of Studies For Birth Season -Fertility Effect mentioning

confidence: 99%

Female Reproductive Performance and Maternal Birth Month: A Comprehensive Meta-Analysis Exploring Multiple Seasonal Mechanisms

Boland

Fieder²,

John

et al. 2020

Sci Rep

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Globally, maternal birth season affects fertility later in life. The purpose of this systematic literature review is to comprehensively investigate the birth season and female fertility relationship. Using PubMed, we identified a set of 282 relevant fertility/birth season papers published between 1972 and 2018. We screened all 282 studies and removed 131 non-mammalian species studies on fertility and 122 studies that were on non-human mammals. Our meta-analysis focused on the remaining 29 human studies, including twelve human datasets from around the world (USA, Europe, Asia). The main outcome was change in female fertility as observed by maternal birth month and whether this change was correlated with either temperature or rainfall. We found that temperature was either strongly correlated or anti-correlated in studies, indicating that another factor closely tied to temperature may be the culprit exposure. We found that rainfall only increases fertility in higher altitude locations (New Zealand, Romania, and Northern Vietnam). This suggests the possibility of a combined or multi-factorial mechanism underlying the female fertility-birth season relationship. We discuss other environmental and sociological factors on the birth season-female fertility relationship. Future research should focus on the role of birth season and female fertility adjusting for additional factors that modulate female fertility as discussed in this comprehensive review. Over 12% of reproductive age women (15-44 years) in the United States of America suffer from infertility or impaired fecundity 1 , with some estimates as high as 16% 2. European countries show similarly high infertility rates with Great Britain at 17% 3. In developing countries, the rate of infertility is estimated at 1 in 4 couples 4,5. In addition to rising infertility rates among humans, increases in infertility and reproductive disorders were observed in dairy cows 6. Dairy researchers found that a cool, low-temperature, environment appeared to preserve fertility and reduce the risk of reproductive disorders 6 furthering support for a relationship between temperature and female fertility. Although at least one study points to other factors besides temperature that play a role more significant role at the country-level on female fertility 7. Maternal birth season effects female fertility outcomes 8 , including in both hunter/gather societies (e.g., Hiwi of Venezuela) 9 and industrialized societies 8,10. Birth season can affect later risk of disease through alterations in the prenatal environment that alter growth patterns and processes 11. In addition, the known relationship between temperature and fertility 6 could also manifest itself in a birth season relationship. The main biological mechanism underlying a birth season relationship with female fertility remains the hypothesis that oocytes' exposure to high temperatures at birth and shortly thereafter results in increased oocyte

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Perinatal winter conditions affect later reproductive performance in romanian women: Intra and intergenerational effects

Abstract: Conflicting results exist between Romania and Austria/New Zealand, and may be most easily explained by women's different exposure to winter conditions in these countries.

Cited by 12 publications

References 34 publications

Effect of religious rules on time of conception in Romania from 1905 to 2001

Effect of religious rules on time of conception in Romania from 1905 to 2001

A model investigating environmental factors that play a role in female fecundity or birth rate

Female Reproductive Performance and Maternal Birth Month: A Comprehensive Meta-Analysis Exploring Multiple Seasonal Mechanisms

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