Perineural invasion in adenoid cystic carcinoma of the salivary glands: A valid prognostic indicator?

Barrett, A.W.; Speight, Paul M.

doi:10.1016/j.oraloncology.2009.07.001

Cited by 146 publications

(120 citation statements)

References 69 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…In the literature, margin status (microscopic and macroscopic) and perineural invasion (most importantly, the major nerves) both variably predicted dfs or os. It is likely that, although a positive resection margin and perineural invasion both adversely affect locoregional outcomes, the addition of adjuvant rt could, to some degree, be able to overcome their impact 35,38,39 . Our study was limited by a small number of patients, its retrospective methodology, and a relatively short follow-up in a disease with a long natural history.…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Siever

Hao

et al. 2016

Current Oncology

View full text Add to dashboard Cite

Objectives Adenoid cystic carcinoma (acc) is often treated with surgery, with or without adjuvant radiation therapy (rt). We evaluated disease characteristics, treatments, and potentially prognostic variables in patients with acc.Methods Our retrospective analysis considered consecutive cases of acc presenting at a tertiary care hospital between 2000 and 2014. Factors predictive of overall survival (os) and disease-free survival (dfs) were identified by univariate analysis. ResultsThe 60 patients analyzed had a mean age of 58 years (range: 22-88 years), with a 2:1 female:male ratio. Tumour locations included the major salivary glands (40% parotid, 17% submandibular and sublingual), the oro-nasopharyngeal cavity (27%), and other locations (16%). Of the 60 patients, 35 (58%) received surgery with adjuvant rt; 12 (20%), rt only; 13 (22%), surgery only. Of 18 patients (30%) who experienced a recurrence within 5 years, 3 (5%) developed local recurrence only, and the remaining 15 (25%), distant metastasis. The 5-year os and dfs were 64.5% [95% confidence interval (ci): 45.9% to 78.1%] and 46.2% (95% ci: 29.7% to 61.2%) respectively. In patients without recurrence, 5-year os was 77% (95% ci: 52.8% to 89.9%), and in patients with recurrence, it was 42.7% (95% ci: 15.8% to 67.6%). Patients treated with rt only had a 5-year os of 9.2%. Predictors of 5-year dfs were TNM stage, T stage, nodal status, treatment received, and margin status; age, nodal status, treatment received, and margin status predicted 5-year os.Conclusions Despite surgery and rt, one third of patients with acc experience distant recurrence. Patients whose tumours are not amenable to surgery have a poor prognosis, indicating a need for alternative approaches to improve outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Siever

Hao

et al. 2016

Current Oncology

View full text Add to dashboard Cite

show abstract

“…Moreover, PNI of SACC could prevent complete surgical resection and lead to a poor prognosis. [4][5][6] Matrix metalloproteinases (MMP), a group of zinc-dependent endopeptidases capable of degrading various components of the extracellular matrix (ECM), is believed to play a vital role in tumor invasion. 7 In many tumors, MMP expression is mainly regulated by extracellular MMP inducer (EMMPRIN, CD147), which is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily.…”

Section: Introductionmentioning

confidence: 99%

EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo

Yang

Zhang

et al. 2012

Cancer Biology & Therapy

View full text Add to dashboard Cite

Salivary adenoid cystic carcinoma (SACC) is a frequent subtype of salivary gland malignancy, and it has an important biological behavior for perineural invasion (PNI). Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that is involved in the invasive property of many malignancies by stimulating matrix metalloproteinase (MMP) expression. The present study was designed to investigate the role and possible mechanism of EMMPRIN in the PNI of SACC using RNA interference (RNAi) technology. We found that silencing of EMMPRIN expression in the human SACC cell line (SACC-83) suppressed the cell proliferation, adhesion, MMP-2 and MMP-9 secretion, and PNI activity in vitro. EMMPRIN silencing also inhibited the tumor growth and K i -67 labeled proliferation index in vivo. Using tumor PNI models in nude mice, EMMPRIN silencing inhibited the infiltration, swelling and functional loss of the affected sciatic nerves, as well as the expression of MMP-2 and MMP-9. These results demonstrate that EMMPRIN participates in the PNI of SACC cells by mediating the expression of MMP-2 and MMP-9. Our findings suggest that EMMPRIN is a potential target for anti-PNI treatment in SACC.

show abstract

“…The fact that it was very difficult to diagnose ACC in the present case in contrast to the previous cases may result from the lack of mass formation in our case. To address this issue, we should focus on the significance of perineural invasion, which frequently occurs during the disease processes of ACC (5,25,26), in tumor spread.…”

Section: Discussionmentioning

confidence: 99%

A Case of Adenoid Cystic Carcinoma Presenting as Garcin's Syndrome without Mass Formation

et al. 2012

View full text Add to dashboard Cite

Adenoid cystic carcinoma (ACC) is a malignant neoplasm that commonly arises in the major or minor salivary gland and usually forms mass lesions. Here, we report a case of ACC involving a 56-year-old man, who displayed right multiple cranial nerve palsies with ipsilateral severe facial pain but not any mass formation. Right submaxillary gland biopsy after repeated challenges at last revealed the primary focus of ACC with perineural invasion and without lymph node metastasis. The neurological manifestations were considered to be attributed to the perineural spread of ACC. It is extremely rare for ACC to show Garcin's syndrome without mass formation.

show abstract

Perineural invasion in adenoid cystic carcinoma of the salivary glands: A valid prognostic indicator?

Cited by 146 publications

References 69 publications

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo

A Case of Adenoid Cystic Carcinoma Presenting as Garcin's Syndrome without Mass Formation

Contact Info

Product

Resources

About