Perineural Invasion is a Better Prognostic Indicator than Lymphovascular Invasion and a Potential Adjuvant Therapy Indicator for pN0M0 Esophageal Squamous Cell Carcinoma

Guo, Yuanning; Tian, Dan; Gong, Qingyun; Huang, Hao; Yang, Peng; Chen, Shaobin; Billan, Salem; He, Jiangjiang; Huang, Haihua; Xiong, Pan; Lin, Wenting; Guo, Dan; Marom, Moshe; Gil, Ziv; Shu, Min

doi:10.1245/s10434-020-08667-4

Cited by 18 publications

(8 citation statements)

References 25 publications

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“…Chen et al analyzed 430 patients with ESCC and reported that PNI can be an independent prognostic factor and that PNI status in primary ESCC should be considered for therapy stratification. 6 Guo et al also analyzed 162 patients with pN0M0 ESCC and concluded that PNI is an important risk factor to determine outcomes and that it can be used for risk assessment and to tailor adjuvant radiotherapy 15 . Our data also showed poor survival in patients with PNI, including in node‐negative patients (Figure 4(a)); hence, it could be an indicator for adjuvant therapy.…”

Section: Discussionsupporting

confidence: 54%

“…Notably, the cumulative incidences of both locoregional recurrence and distant metastasis over three years were higher in the PNI group, meaning that PNI was related to both locoregional and distant failures. Although Guo et al reported that PNI could be an indicator for adjuvant radiotherapy, 15 we considered that both adjuvant chemotherapy for distant metastasis and adjuvant radiotherapy for local control may be beneficial for patients with PNI. The appropriate modality of adjuvant therapy should be studied in further analyses.…”

Section: Discussionmentioning

confidence: 98%

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Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

et al. 2021

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Background Although perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcinoma. Methods We retrospectively reviewed the medical records of 316 patients who underwent esophagectomy and lymph node dissection for esophageal squamous cell carcinoma between 2007 and 2016. Results Overall, 287 men (mean age: 62.73 ± 7.97 years) were included in the study. The median follow‐up period was 35.97 ± 30.99 months, perineural invasion was confirmed in 25 patients, and three‐year overall and disease‐free survival were significantly lower in the perineural invasion group than in the no‐perineural invasion group (75.9% vs. 40.0%, p < 0.001; 70.3% vs. 21.6%, p < 0.001). Cumulative incidences of locoregional recurrence and distant metastasis over three years were higher in the perineural invasion group (13.8% vs. 9.6%, p = 0.009 and 52.8% vs. 14.6%, p < 0.001). On performing multivariable analysis, perineural invasion, pathological stage, incomplete resection, and neoadjuvant therapy were adverse risk factors for disease‐free survival. The concordance index increased when perineural invasion was included in the model (0.712 vs. 0.723). On subgroup analysis, perineural invasion demonstrated a prognostic value in node‐negative patients (79.4% vs. 35.7%, p = 0.012). Conclusions Perineural invasion was found to be an adverse risk factor for disease‐free survival in surgically treated patients with esophageal squamous cell carcinoma. Close observation and individualized adjuvant therapy may be helpful for patients with perineural invasion.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 98%

Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

et al. 2021

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“…Some of the reasons may be the difficulty in reproducing genuine LVI with the use of D2-40 or CD34 besides H&E to improve the detection rate by staining endothelial cells. But in the study of Guo et al 20 in 162 node-negative ESCC patients, the association of LVI detected by D2-40 or CD31 was weak, and no further attempt was made to differentiate between vascular and lymphatic vessels.…”

Section: Discussionmentioning

confidence: 98%

Identification and Prognostic Effect of Extramural Venous Invasion in Locally Advanced Esophageal Squamous Cell Carcinoma

Zhao

Plukker

Tian

et al. 2023

American Journal of Surgical Pathology

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The role of extramural venous invasion (EMVI) in esophageal cancer is still unclear. This study aimed to identify EMVI and assess its impact on survival and recurrences in esophageal squamous cell carcinoma (ESCC). Retrospectively, we reviewed resection specimens of 147 locally advanced ESCC (pT3-T4aN0-3M0) patients who had a curative intended surgery alone at the Cancer Hospital of Shantou University from March 2009 to December 2013. After confirming pT≥3 in hematoxylin-eosin tumor slides, EMVI was evaluated by Verhoeff and Caldesmon staining. The impact of EMVI with other clinicopathological characteristics and survival were analyzed using the χ2 test, Cox regression, and Kaplan-Meier method. EMVI was present in 30.6% (45/147) of the P≥T3 ESCCs and associated with lymph-vascular invasion and poor differentiation grade (P<0.05). Disease-free survival and overall survival in patients with EMVI-absent tumors were about 2.0 times longer than in those with EMVI-present tumors. In pN0 patients, EMVI-presence was associated with poor overall survival (HR 4.829, 95% CI 1.434–16.26, P=0.003) and Disease-free Survival (HR 4.026, 95% CI 0.685–23.32, P=0.018). In pN1-3 patients, EMVI had no additional effect on survival. Conclusions EMVI has an independent adverse prognostic effect on survival in ESCC patients after surgery alone. EMVI should be included in pathology reports as it might contribute to identify high-risk patients for potential additional treatment.

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“…PNI was correlated with reduced survival [ 100 ], which supports previous findings that nerve invasion by tumour cells can be used as a prognostic factor in patients with esophageal cancer [ 101 , 102 ]. PNI was also found to be a better prognostic indicator than lymphovascular invasion in ESCC [ 103 ].…”

Section: Schwann Cell Involvement In Physiology and Disorders Of The ...mentioning

confidence: 99%

Schwann Cells in Digestive System Disorders

Goluba

Kunrade

Riekstiņa

et al. 2022

Cells

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Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric nervous system (ENS), while the extrinsic part is formed by sympathetic, parasympathetic, and sensory branches of the PNS. Glial cells are a crucial component of digestive tract innervation, and a great deal of research evidence highlights the important status of ENS glia in health and disease. In this review, we shift the focus a bit and discuss the functions of Schwann cells (SCs), the glial cells of the extrinsic innervation of the digestive system. For more context, we also provide information on the basic findings regarding the function of innervation in disorders of the digestive organs. We find diverse SC roles described particularly in the mouth, the pancreas, and the intestine. We note that most of the scientific evidence concerns the involvement of SCs in cancer progression and pain, but some research identifies stem cell functions and potential for regenerative medicine.

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Perineural Invasion is a Better Prognostic Indicator than Lymphovascular Invasion and a Potential Adjuvant Therapy Indicator for pN0M0 Esophageal Squamous Cell Carcinoma

Cited by 18 publications

References 25 publications

Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma

Identification and Prognostic Effect of Extramural Venous Invasion in Locally Advanced Esophageal Squamous Cell Carcinoma

Schwann Cells in Digestive System Disorders

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