Periodic leg movements and restless legs syndrome

Hohl-Radke, Felix; Staedt, J.

doi:10.1007/s11818-009-0425-5

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…In this observational, cross-sectional study, we found RLS frequency in 25% of outpatients who received SSRI/SNRIs for 4–8 weeks which is higher than the RLS prevalence both in the general population (5.5%) (Ohayon and Roth, 2002) and also psychiatric inpatients reported between 16.4 and 19.7% (Hohl-Radke and Staedt, 2009; Weber et al , 2022). There is a wide variation in the RLS frequency between the studies, which could be attributable to differences in risk factors of study populations and the determination of RLS with different assessment tools (Nichols et al ., 2003; Innes et al ., 2011; Patatanian and Claborn, 2018; Elrassas et al ., 2022).…”

Section: Discussionmentioning

confidence: 64%

Frequency, risk factors, and impacts on quality of life of the restless legs syndrome and side effects among antidepressant users in a tertiary hospital: an observational cross-sectional study

Erdem

Kara²,

Ozcelik³

et al. 2023

International Clinical Psychopharmacology

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Restless leg syndrome (RLS) is a common but underestimated sensorimotor disorder that significantly affects the quality of life (QoL) which can be induced by antidepressants. This study aims to investigate the frequency and potential risk factors of RLS and side effects in selective serotonin reuptake inhibitors/ serotonin and noradrenaline reuptake inhibitors (SSRI/SNRI) users. This cross-sectional study included 198 outpatients who received SSRI/SNRI for 4-8 weeks. Clinical evaluation was performed using the International Restless Leg Syndrome Study Group rating scale for RLS, Udvalg for Kliniske Undersøgelser side effects rating scale, and a short form 36 (SF-36) questionnaire for QoL. The frequency of RLS was 25%. RLS significantly increased with smoking and habituality. Also, habituality increased neurologic side effects reporting. The use of antipsychotics and calcium channel blockers decreased reporting of autonomic side effects. QoL decreased with RLS, psychiatric, neurologic, autonomic, and other side effects in different domains of SF-36. These findings suggested that SSRI/SNRI use could be associated with a higher risk of RLS, especially in smokers. QoL could be influenced negatively by RLS and all side effects. However, further prospective studies are needed to confirm these associations in large samples.

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Section: Discussionmentioning

confidence: 64%

Frequency, risk factors, and impacts on quality of life of the restless legs syndrome and side effects among antidepressant users in a tertiary hospital: an observational cross-sectional study

Erdem

Kara²,

Ozcelik³

et al. 2023

International Clinical Psychopharmacology

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“…According to the IRLS, RLS in our patients was moderate to severe. A prior study in a smaller sample of 117 hospitalized psychiatric patients reported an RLS prevalence of 19.7% ( 39 ). In contrast to the present study, only patients with comorbid severe sleep disturbances such as insomnia, dyssomnia or daytime sleepiness were included in this retrospective analysis, precluding direct comparison with the present results.…”

Section: Discussionmentioning

confidence: 95%

“…Despite the close relationship between RLS and psychiatric disorders, studies on the prevalence of RLS in psychiatric patients are scarce and refer to limited patient samples in Asia ( 35 – 37 ) or otherwise strongly selected psychiatric samples ( 38 , 39 ). The aim of the present study was to estimate the prevalence and assess the clinical correlates of RLS in a larger sample of psychiatric inpatients in Germany and Switzerland.…”

Section: Introductionmentioning

confidence: 99%

Restless Legs Syndrome Prevalence and Clinical Correlates Among Psychiatric Inpatients: A Multicenter Study

et al. 2022

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BackgroundThere are only limited reports on the prevalence of restless legs syndrome (RLS) in patients with psychiatric disorders. The present study aimed to evaluate the prevalence and clinical correlates in psychiatric inpatients in Germany and Switzerland.MethodsThis is a multicenter cross-sectional study of psychiatric inpatients with an age above 18 years that were diagnosed and evaluated face-to-face using the International RLS Study Group criteria (IRLSSG) and the International RLS severity scale (IRLS). In addition to sociodemographic and biometric data, sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Patient Health Questionnaire (PHQ-9). In addition to univariate statistics used to describe and statistically analyze differences in variables of interest between patients with and without RLS, a logistic model was employed to identify predictors for the occurrence of RLS.ResultsThe prevalence of RLS in a sample of 317 psychiatric inpatients was 16.4%, and 76.9% of these were diagnosed with RLS for the first time. RLS severity was moderate to severe (IRLS ± SD: 20.3 ± 8.4). The prevalences in women (p = 0.0036) and in first-degree relatives with RLS (p = 0.0108) as well as the body mass index (BMI, p = 0.0161) were significantly higher among patients with RLS, while alcohol consumption was significantly lower in the RLS group. With the exception of atypical antipsychotics, treatment with psychotropic drugs was not associated with RLS symptoms. Regarding subjective sleep quality and mood, scores of the PSQI (p = 0.0007), ISI (p = 0.0003), and ESS (p = 0.0005) were higher in patients with RLS, while PHQ-9 scores were not different. A logistic regression analysis identified gender (OR 2.67; 95% CI [1.25; 5.72]), first-degree relatives with RLS (OR 3.29; 95% CI [1.11; 9.73], ESS score (OR 1.09; 95% CI [1.01; 1.17]), and rare alcohol consumption (OR 0.45; 95% CI [0.22; 0.94] as predictors for RLS.ConclusionsClinically significant RLS had a high prevalence in psychiatric patients. RLS was associated with higher BMI, impaired sleep quality, and lower alcohol consumption. A systematic assessment of restless legs symptoms might contribute to improve the treatment of psychiatric patients.

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“…The rate of RLS in a German study done in 117 psychiatric inpatients was 19.7% using the IRLSSG criteria, and nearly one-fourth of the total patients were diagnosed with periodic-leg movement disorder too. [ 28 ] No significant gender association with symptoms of RLS was observed, however. In an Asian study which evaluated various sleep disorders among psychiatric outpatients, Hombali et al .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical correlates of restless legs syndrome in psychiatric patients: A cross-sectional study from North India

Aneja,

Singh,

Udey

2024

Indian Journal of Psychiatry

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Background: Restless legs syndrome (RLS) is a neuro-sensorimotor disorder which is scarcely researched and is commonly missed in routine psychiatry practice. Aim: To evaluate the prevalence of RLS and its correlates in patients with anxiety, depression, and somatoform disorders. Methods: A cross-sectional single-center study was undertaken in patients aged 18–65 years suffering from ICD-10 (International Statistical Classification of Diseases-10th edition) diagnosis of anxiety, depressive, and somatoform disorders. RLS was evaluated by using diagnostic criteria of International Restless Legs Syndrome Study Group (IRLSSG) and severity measured on IRLSSG scale. Depression and anxiety were rated on Hamilton Depression and Anxiety Rating Scales respectively, insomnia severity measured by Insomnia Severity Index (ISI), and quality of life measured by WHO Quality of Life-Brief version (WHO-QOL BREF) scale. Serum ferritin levels were measured for evaluating iron deficiency. Results: The rate of RLS was 66.7%, 50%, and 48% in patients with depressive, anxiety, and somatoform disorders, respectively, with no significant inter-group difference. Nearly one-third of patients suffered from severe to very severe symptoms of RLS, and quality of life was poorest in those with depressive disorders. RLS was significantly higher in females (P = 0.019), who were married (P = 0.040), diagnosed with severe depression (P = 0.029), and abused benzodiazepines (P = 0.045). On binary logistic regression, female gender and presence of clinical insomnia predicted occurrence of RLS. Conclusion: The prevalence of RLS is very high in patients with common psychiatric disorders which is often missed. Clinical enquiry and examination for reversible causes such as iron deficiency may assist in its diagnosis and improve clinical outcome.

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Periodic leg movements and restless legs syndrome

Cited by 3 publications

References 41 publications

Frequency, risk factors, and impacts on quality of life of the restless legs syndrome and side effects among antidepressant users in a tertiary hospital: an observational cross-sectional study

Frequency, risk factors, and impacts on quality of life of the restless legs syndrome and side effects among antidepressant users in a tertiary hospital: an observational cross-sectional study

Restless Legs Syndrome Prevalence and Clinical Correlates Among Psychiatric Inpatients: A Multicenter Study

Prevalence and clinical correlates of restless legs syndrome in psychiatric patients: A cross-sectional study from North India

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