Periodic Sharp Waves in Baclofen-Induced Encephalopathy

Pregabalin intoxication-induced encephalopathy with triphasic waves

“…Triphasic waves (TWs), originally described in hepatic encephalopathy, are a distinctive electroencephalographic pattern observed in many patients with a decreased level of consciousness [4]. Triphasic waves are also observed in toxic encephalopathies, such as valproateinduced hyperammonemic encephalopathy, serotonin syndrome, and intoxication by baclofen, lithium, levodopa, pentobarbital, cefepime, tiagabine, or ifospamide [5][6][7][8][9][10][11]. However, an association between PGB intoxication and TWs has not been reported.…”

Electroencephalographic abnormalities in baclofen-induced encephalopathy

“…7 The first instance of baclofen toxicity was reported in 1976 in a 29-year-old woman whose EEG revealed a burst-suppression pattern 16 hours after her overdose. 10 Since then, a variety of electroencephalographic abnormalities have been reported with baclofen overdose including non-specific diffuse background slowing, burstsuppression pattern, 11 quasiperiodic generalized epileptiform activity, 12 periodic triphasic sharp waves 13,14 and rhythmic generalized high-amplitude delta waves. 15 A burst-suppression pattern, with bursts consisting of pseudoperiodic discharges followed by electrodecremental response was seen in our patient.…”

Baclofen-induced frontal lobe syndrome

“…With therapeutic doses of baclofen, the side effects of transient drowsiness and other mental symptoms, including hallucinations, euphoria, mental excitation, depression, confusion or anxiety, occur most commonly in patients with a history of psychiatric or some other brain disorder; also in geriatric patients (White 1985;Yassa and Iskandar, 1988). Transient EEG abnormalities due to baclofen, such as bursts of triphasic waves (Abarbanel et al, 1985) and periodic sharp waves (Hormes et al, 1988), have been reported.…”