Periodontal and peri-implant hard tissue regeneration

Paknejad, Zahrasadat; Jafari, Maissa; Nazeman, Pantea; Rad, Maryam Rezai; Khojasteh, Arash

doi:10.1016/b978-0-08-100961-1.00024-4

Cited by 4 publications

(2 citation statements)

References 122 publications

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“…Nowadays, there are various implants (commercially available) for the treatment of the bone defects in the jaws. However, due to the prevalence and complexity of these diseases, the lack of complete restoration after the use of traditional implants, and the long duration of jaw tissue repair many studies have been done to introduce more appropriate implants (Paknejad, Jafari, Nazeman, Rad, & Khojasteh, ; Shan, Chen, Liang, Huang, & Cai, ). In recent decades, tissue engineering has tried introducing dental bioimplants using a set of techniques.…”

Section: Introductionmentioning

confidence: 99%

Efficient osteogenic differentiation of the dental pulp stem cells on β‐glycerophosphate loaded polycaprolactone/polyethylene oxide blend nanofibers

Hosseini

Enderami

Hadian

et al. 2019

Journal Cellular Physiology

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Hard tissue lesion treatment in oral and maxillofacial has been challenging because of tissue complexities. This study aimed to investigate novel biopolymeric construct effects on the osteogenic differentiation potential of the dental pulp stem cells (DPSCs) for introducing a cell copolymer bioimplant. A blended polycaprolactone (PCL)‐polyethylene oxide (PEO) was fabricated using electrospinning, simultaneously filled by β‐glycerophosphate (β‐GP). After that biocompatibility and release kinetics of the PCL‐PEO+β‐GP was evaluated and compared with PCL‐PEO and then the osteogenic differentiation potential of the DPSCs was examined while being cultured on the scaffolds and compared with those cultured on the culture plate. The results demonstrated that scaffolds have not any cytotoxicity and β‐GP can release in a long‐term manner. Alkaline phosphatase activity and calcium content were significantly increased in DPSCs while being cultured on the PCL‐PEO+β‐GP compared with the other groups. Runt‐related transcription factor 2, collagen type‐I, osteonectin, and osteocalcin (OSC) genes expression was upregulated in DPSCs cultured on the PCL‐PEO+β‐GP and was significantly higher than those cultured on the PCL‐PEO. Immunocytochemistry result also confirmed the positive effects of PCL‐PEO+β‐GP on the osteogenic differentiation of the DPSCs by presenting a higher OSC protein expression. According to the results, incorporation of the β‐GP in PCL‐PEO makes a better construct for osteogenic induction into the stem cells and it could be also considered as a great promising candidate for bone, oral, and maxillofacial tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Efficient osteogenic differentiation of the dental pulp stem cells on β‐glycerophosphate loaded polycaprolactone/polyethylene oxide blend nanofibers

Hosseini

Enderami

Hadian

et al. 2019

Journal Cellular Physiology

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“…Postextraction bone resorption creates defects in the alveolar bone which leads to the impairment of prognosis in prosthodontic treatment. Socket grafting represents one socket preservation method performed following a tooth extraction, intended to preserve and maintain the volume of alveolar bone by filling the tooth socket with bone material substitute (Paknejad et al, 2017). The bone material subtitute used in this research is DFDBBX, manufactured by Pusat Aplikasi Isotop dan Radiasi Badan Tenaga Nuklir Nasional.…”

Section: Discussionmentioning

confidence: 99%

The potential for induction of the expression of bone morphogenetic protein-7 and alkaline phosphatase in postextraction tooth sockets using a combination of mangosteen peel extract and DFDBBX

Kresnoadi¹,

Amelia²,

Laksono³

2022

J App Pharm Sci

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This study was determined to verify that the combination of DFDBBX and mangosteen peel extract can increase the expression of bone morphogenetic protein-7 (BMP-7) and alkaline phosphatase (ALP) in tooth sockets on days 7 and 30 after extraction. The central lower incisors of Cavia cobaya were extracted using a needle holder, after which polyethylene glycol (PEG), DFDBBX + PEG, mangosteen peel extract + PEG, and a combination of DFDBBX + mangosteen peel extract + PEG were applied to the tooth socket. On days 7 and 30, the C. cobaya were sacrificed, their lower jaws were soaked in ethylenediaminetetraacetic acid and block paraffin, and a slide was made. Finally, an immunohistochemical examination of the expression of B MP-7 and ALP was performed. Statistical analysis by means of the analysis of variance indicated that each group was significantly different. The combination group showed the highest expression of BMP-7 and ALP on days 7 and 30, followed by the mangosteen peel extract group. A combination of DFDBBX and mangosteen peel extract 2% was applied to the C. cobaya tooth socket after extraction which increased the expression of BMP-7 and ALP on days 7 and 30.

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Ridge Defects (Localised)

2018

Diseases and Conditions in Dentistry

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Periodontal and peri-implant hard tissue regeneration

Cited by 4 publications

References 122 publications

Efficient osteogenic differentiation of the dental pulp stem cells on β‐glycerophosphate loaded polycaprolactone/polyethylene oxide blend nanofibers

Efficient osteogenic differentiation of the dental pulp stem cells on β‐glycerophosphate loaded polycaprolactone/polyethylene oxide blend nanofibers

The potential for induction of the expression of bone morphogenetic protein-7 and alkaline phosphatase in postextraction tooth sockets using a combination of mangosteen peel extract and DFDBBX

Ridge Defects (Localised)

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