Periodontal condition and microbiology of healthy and diseased periodontal pockets in type 1 diabetes mellitus patients

Abstract

On the basis of glycosylated hemoglobin (HbA1c) values, 22 type 1 (insulin-dependent) diabetic adults were grouped into patients with near normal (HbA1c less than or equal to 7.7%) and poor (HbA1c greater than or equal to 9.9%) metabolic control. A total of 44 subgingival sites were examined for Actinobacillus actinomycetemcomitans, black-pigmented Bacteroides species and Capnocytophaga species. No significant difference could be demonstrated between patients in the 2 test groups with regard to periodontal condition. Neither age of diabetic patients nor duration of diabetes mellitus influenced the periodontal parameters. In both test groups, pocket depth of 4 mm or more (greater than or equal to 4 mm) was found to be significantly associated with increased swelling, bleeding after probing and amount of marginal plaque. Proportionally high %s of cultivable A. actinomycetemcomitans (mean 4.3%; range 2.8-5.8%), Bacteroides gingivalis (33.2% and 34.6%) and Bacteroides intermedius (mean 4.2%; range 0.001-13.5%) were isolated from diseased periodontal pockets. In diabetic patients with poor metabolic control, B. intermedius was isolated from diseased periodontal pockets with a mean % of 7.2%, range 0.3-12.5%. Independent of the degree of metabolic control, low %s of Capnocytophaga species were isolated from diseased and healthy periodontal pockets, mean 0.9% (range 0.003-3.9%) and mean 1.4% (range 0.04-4.9%), respectively. It was concluded from this study that metabolic control seems to have no direct effect on the periodontium. Furthermore, the rôle of Capnocytophaga species in the pathogenesis of infectious periodontal disease in type 1 diabetic patients seems to be overestimated.(ABSTRACT TRUNCATED AT 250 WORDS)

The Influence of Smoking and Non-Insulin-Dependent Diabetes Mellitus on Periodontal Disease

“…37 In several studies, rapid periodontal breakdown in adults with poorly controlled diabetes as a result of high blood glucose levels was reported. 37 -39 However, Sastrowijoto et al 40 found that although metabolic control was improved by conventional insulin treatment in IDDM patients, no improvement was seen in the clinical periodontal condition, with the exception of a decrease in gingival redness.…”

Presencia de Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola y Aggregatibacter actinomycetemcomitans en el biofilm subgingival de pacientes diabéticos tipo 2: estudio transversal

“…El análisis del PCR de nuestra investigación muestran una alta presencia de Treponema denticola y Tannerella forsythia, seguida de Porphyromonas gingivalis y Aggregatibacter actinomycetemcomitans (Tabla 5). Estos resultados son similares a los obtenidos por Makiura y cols (29) , sin embargo contrastan con otros estudios que detectaron mayor presencia de Porphyromonas gingivalis que de Treponema denticola y Aggregatibacter actinomycetemcomitans (30)(31)(32)(33) . Al analizar la presencia de las bacterias estudiadas según severidad de la periodontitis, Treponema denticola, Tannerella forsythia y Porphyromonas gingivalis se presentaron en mayor porcentaje en los sujetos con periodontitis moderada y severa.…”

Diabetes and periodontal disease: a two way relation – a commentary

“…Sastrowijotosh et al (1989) showed that Capnocytophaga species were isolated at very low levels, in both the diseased and healthy periodontal pockets (8). Thus the role of Capnocytophaga species in the pathogenesis of infectious periodontal disease in patients with type I diabetes may be over estimated.…”