Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats

Scarabelot, Vanessa Leal; Cavagni, Juliano; Medeiros, Liciane Fernandes; Detanico, Bernardo Carraro; Rozisky, Joanna Ripoll; Souza, Andressa de; Daudt, Luciana Dondonis; Gaio, Eduardo José; Ferreira, Maria Beatriz Cardoso; Rösing, Cassiano Kuchenbecker; Battastini, Ana Maria Oliveira; Torres, Iraci Lucena da Silva

doi:10.1016/j.archoralbio.2014.05.004

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Studies on patients on long‐term steroid therapy for medical conditions have demonstrated an anti‐inflammatory effect of corticosteroids on gingival tissues . Previous research on animals has indicated that a long‐term administration of low doses of inhaled corticosteroids may reverse the effects of periodontal disease . In a comparatively younger study population with fair/good oral hygiene levels and practices as found in our study, the anti‐inflammatory effect may outweigh the immunosuppressant effect of respiratory medications resulting in lower levels of periodontal disease.…”

Section: Discussionsupporting

confidence: 45%

The effect of 6 months or longer duration of chronic obstructive respiratory disease medication on the oral health parameters of adults

Raj

Manu

Prakash

et al. 2018

Special Care in Dentistry

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The objectives of this study were to study the effect of COPD medication of 6 months or more duration on oral health parameters of adult patients. A cross-sectional study was conducted to assess and compare the decayed, missing, and filled teeth (DMFT), oral hygiene index-simplified (OHI-S), periodontal disease index (PDI) scores, and presence of candida (colony-forming units [CFU]) among adult patients aged 20-45 years who had a history of 6 months or longer duration usage of chronic respiratory disease medications, with controls. A total of 170 participants each were taken in both the groups. Oral health parameters like DMFT scores (p ≤ 0.002), OHI-S (p ≤ 0.001), calculus scores (p ≤ 0.001), plaque scores (p ≤ 0.001), and CFU/ml of candida species (p ≤ 0.001) were higher among cases than controls. DMFT scores and candida presence were significantly higher among those whose treatment duration was greater than 5 years as compared to those with lesser duration. Gingival-periodontal component scores of PDI were lower among cases than controls (p ≤ 0.001). Our findings suggest the need for regular oral health maintenance for those under COPD treatment and for greater research into the possible protective role of inhaled corticosteroids in limiting periodontal disease among patients.

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Section: Discussionsupporting

confidence: 45%

The effect of 6 months or longer duration of chronic obstructive respiratory disease medication on the oral health parameters of adults

Raj

Manu

Prakash

et al. 2018

Special Care in Dentistry

View full text Add to dashboard Cite

show abstract

“…Similarly, diabetes mellitus also is considered to be a major risk factor with an approximate threefold increase, compared with nondiabetic individuals (Preshaw et al, 2012). Other systemic factors such as chemotherapy, systemic steroids, and hormone T A B L E 1 Mean percentage of teeth with elevated periodontal probing depths in patients using PPIs versus not using PPIs replacement therapy, as well as non-thyroid autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, have the potential to affect the severity of periodontal diseases (Marques et al, 2016;Marques & Dib, 2004;Mayer et al, 2013;Scarabelot et al, 2014). Consequently, smokers and diabetics, as well as patients having other potential systemic confounding factors, subsequently were excluded from the analysis.…”

Section: Discussionmentioning

confidence: 99%

Association between proton pump inhibitors and periodontal disease severity

Chawla

Cohen

Yerke

2021

Clinical & Exp Dental Res

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Objectives: Proton pump inhibitors (PPIs) are commonly prescribed for the management of acid-related gastrointestinal disorders. PPIs modulate osteoclast function, reduce gastric acid secretion, and are associated with the establishment of a more diverse gastrointestinal microbiota. Periodontitis is characterized by microbeassociated host-mediated inflammation that results in loss of periodontal attachment.The aim of this study was to assess whether a relationship exists between PPIs and periodontal disease. Materials and methods:A retrospective analysis was performed using patient records from a faculty periodontal practice. The proportion of elevated probing depths was used to measure periodontitis severity. Statistical analysis was performed using independent sample t-tests, and Chi-square tests of independence.Results: Records from 1093 patients were initially assessed. Fourteen percent of teeth were associated with ≥6 mm probing depths among PPI users, in contrast to 24% for patients not using PPIs (P = 0.030). Similarly, 27% of teeth exhibited ≥5 mm probing depths among PPI users versus 40% for non-PPI users (P = 0.039). Conclusions:The results suggest that PPIs are associated with a reduced proportion of elevated probing depths. Future prospective studies are indicated to elucidate possible mechanisms through which PPIs might affect, and potentially be used in the treatment of, periodontitis.

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Histamine stimulates secretion of extracellular vesicles with nucleotidase activity in rat submandibular gland

González

Haaster

Villarruel

et al. 2018

Archives of Oral Biology

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Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats

Cited by 6 publications

References 46 publications

The effect of 6 months or longer duration of chronic obstructive respiratory disease medication on the oral health parameters of adults

The effect of 6 months or longer duration of chronic obstructive respiratory disease medication on the oral health parameters of adults

Association between proton pump inhibitors and periodontal disease severity

Histamine stimulates secretion of extracellular vesicles with nucleotidase activity in rat submandibular gland

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