Periodontal disease and systemic health: A review

Mani, A.; Mani, Shubhangi; Sodhi, Neha; Anarthe, Raju; Saini, Rajiv

doi:10.5958/j.2319-5886.2.3.044

Cited by 2 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 13,70 ] Consequently, accumulated platelets on the hydrogel would stimulate the blood coagulation cascade. [ 71 ] In addition, TA has a vasoconstriction effect [ 72 ] and can make interaction with proteins of blood, [ 30 ] providing a synergistic effect for the hemostasis ability of GelTA and GelTA‐Alla hydrogels. Therefore, cessation of bleeding was a result of vasoconstriction and clot formation.…”

Section: Resultsmentioning

confidence: 99%

“…Dried GelTA hydrogel (0.1 g) was immersed in 40 mL of PBS and incubated under shaking (100 rpm) at 37°C. At pre-determined time points (0.5, 1,2,4,8,12,24,48,72,144,240, and 336 h), 1 mL of release medium solution was withdrawn for the determination of the TA released from the hydrogel. In all time points, the withdrawn volume was replaced with fresh PBS buffer to maintain the total volume of the release media constant.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration

Ahmadian

Correia

Hasany

et al. 2020

Adv Healthcare Materials

189

179

View full text Add to dashboard Cite

Generation of reactive oxygen species, delayed blood clotting, prolonged inflammation, bacterial infection, and slow cell proliferation are the main challenges of effective wound repair. Herein, a multifunctional extracellular matrix‐mimicking hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid (TA) as a green chemistry approach. The hydrogel shows adjustable physicochemical properties by altering the concentration of TA and it represents high safety features both in vitro and in vivo on fibroblasts, red blood cells, and mice organs. In addition to the merit of facile encapsulation of cell proliferation‐inducing hydrophilic drugs, accelerated healing of skin injury is obtained through pH‐dependent release of TA and its multifaceted mechanisms as an antibacterial, antioxidant, hemostatic, and anti‐inflammatory moiety. The developed gelatin‐TA (GelTA) hydrogel also shows an outstanding effect on the formation of extracellular matrix and wound closure in vivo via offered cell adhesion sites in the backbone of gelatin that provide increased re‐epithelialization and better collagen deposition. These results suggest that the multifunctional GelTA hydrogel is a promising candidate for the clinical treatment of full‐thickness wounds and further development of wound dressing materials that releases active agents in the neutral or slightly basic environment of infected nonhealing wounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration

Ahmadian

Correia

Hasany

et al. 2020

Adv Healthcare Materials

189

179

View full text Add to dashboard Cite

show abstract

“…Both conditions have the potential to cause an inflammatory response, which results in the release of inflammatory mediators. These proinflammatory cytokines such as interleukin (IL)-6 impair the glucose-stimulated release of insulin from the pancreas 20 . Recent epidemiologic studies have found that patients with chronic periodontitis have higher glycemic levels compared to non-peri-odontitis healthy individuals, and the improvement in oral hygiene has a beneficial effect on controlling glycemic levels 21 .…”

Section: Periodontitis As a Risk Factor For Systemic Diseasesmentioning

confidence: 99%

Association between Periodontitis and Liver Disease

Rinčić

Gaćina

Jukić

et al. 2021

ACC

View full text Add to dashboard Cite

Recent clinical and scientific evidence confirms the negative impact of long-term periodontitis on the clinical course and progression of various liver diseases. Periodontitis is a chronic, slow-progressing infectious disease of the tooth supporting tissues caused mainly by the gram-negative bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola and Tannerella forsythia. These specific pathogens can be easily translocated from oral cavity to the intestine. Disruption of the intestine microbiota composition by orally derived periodontal pathogenic bacteria has recently been suggested to be a causal mechanism between periodontitis and liver disease. Furthermore, both diseases have the ability to induce an inflammatory response and lead to the creation of inflammatory mediators through which they may influence each other. Recent epidemiologic studies have demonstrated that individuals with liver cirrhosis have considerably poorer periodontal clinical parameters than those without cirrhosis. Periodontal therapy in cirrhosis patients favorably modulates oral and gut microbiome, the course of systemic inflammation, cirrhosis prognostic factors, and cognitive function. Therefore, future clinical researches should be focused on detailed examination of the biological mechanisms, strength and direction of the association between advanced liver disease and periodontitis.

show abstract

Periodontal disease and systemic health: A review

Cited by 2 publications

References 14 publications

A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration

A Hydrogen‐Bonded Extracellular Matrix‐Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH‐Responsive Wound Healing Acceleration

Association between Periodontitis and Liver Disease

Contact Info

Product

Resources

About