Periodontal Disease in Individuals With a Genetic Risk of Developing Arthritis and Early Rheumatoid Arthritis: A Cross‐Sectional Study

Bello-Gualtero, J.; Lafaurie, Gloria Inés; Hoyos, Lida X.; Castillo, Diana Marcela; Ávila, Juliette De; Munévar, Juan Carlos; Unriza, Sonia; Londoño, John; Valle-Oñate, Rafael; Romero-Sánchez, Consuelo

doi:10.1902/jop.2015.150455

Cited by 72 publications

(80 citation statements)

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“…Although P gingivalis is not a marker of periodontitis, citrullination in the periodontium can be performed by the enzyme of this bacterium suggesting P gingivalis could be a possible link between periodontitis and RA as a mechanism of ending the patient's immunological tolerance . Increased concentrations of antibodies against P gingivalis before the onset of RA symptoms are associated with ACPAs and RA disease activity markers . Similarly, FDR has high periodontal involvement .…”

Section: Discussionmentioning

confidence: 99%

“…Increased concentrations of antibodies against P gingivalis before the onset of RA symptoms are associated with ACPAs and RA disease activity markers . Similarly, FDR has high periodontal involvement . Obesity, ACPAs and periodontitis can be relevant conditions associated with the development of RA in FDR .…”

Section: Discussionmentioning

confidence: 99%

“…The unknown plaque samples were extrapolated onto a standard curve of log‐transformed data from P gingivalis 16S rRNA (ATCC‐33277). Finally, to determine immunoglobulin G1 (IgG1) and IgG2 antibodies against P gingivalis , we used enzyme‐linked immunosorbent assay (ELISA) “in house” …”

Section: Methodsmentioning

confidence: 99%

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Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

et al. 2019

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Objective:To evaluate the adipokine levels in early rheumatoid arthritis (eRA) and first-degree relatives (FDR) of patients with RA and establish their association with rheumatic disease activity and periodontal variables. Method:A cross-sectional study with eRA patients, FDR and a healthy population.Adipokine levels, clinical, joint radiological indexes and periodontal variables were evaluated. A descriptive, bivariate analysis was performed based on the adipokine levels by χ 2 , Fisher's test and Mann-Whitney U test. A logistic regression was made for associations. Results:High leptin levels were associated with the diagnosis of eRA (odds ratio[OR] = 2.79; 95% CI 1.54-5.07). Early rheumatoid arthritis with high adiponectin levels was less likely to have Multidimensional Health Assessment Questionnaire score >3, body mass index (BMI) >25 and Routine Assessment of Patient Index Data 3 score >12 (OR = 0.16; 95% CI 0.03-0.72). Early rheumatoid arthritis was more likely to present high leptin and interleukin (IL)6 levels with low adiponectin simultaneously (OR = 5.03; 95% CI 1.05-24.0). High leptin levels were associated with the FDR adjusted for IgG2 Porphyromonas gingivalis, swollen joints, P gingivalis and low IL6 (OR = 2.57; 95% CI 1.14-5.95). Conclusion:High adipokine levels in eRA may modulate the disease activity. Having more than 1 adipokine at high serum levels is associated with increased disability, disease activity and BMI, indicating that RA is controlled by adiponectin levels in the early stages of the disease. High leptin levels, presence of P gingivalis and swollen joints may be the factors associated with the development of RA in FDR. K E Y W O R D Sadipokines, adiponectin, leptin, periodontitis, rheumatoid arthritis | 1991 CHAPARRO-SANABRIA et Al.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

et al. 2019

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“…P. gingivalis possesses a PAD enzyme that is capable of citrullinating fibrinogen and α-enolase, both of which are potential targets for ACPAs [69]. Indeed, in individuals with genetic risk factors for RA, antibodies to P. gingivalis have been associated with systemic RA-related autoantibodies [70, 71]. More recently, it has been shown that P. gingivalis PAD can undergo autocitrullination and that antibodies directed against this citrullinated form of PAD are more prevalent in RA patients compared to controls [72].…”

Section: Periodontal Tissue In Pre-symptomatic Rheumatoid Arthritismentioning

confidence: 99%

Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?

2017

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It is well recognised that a state of autoimmunity, in which immunological tolerance is broken, precedes the development of symptoms in the majority of patients with rheumatoid arthritis (RA). For individuals who will later develop seropositive disease, this manifests as autoantibodies directed against proteins that have undergone specific post-translational modifications. There is evidence that the induction of this autoantibody response occurs at peripheral extra-articular mucosal sites, such as the periodontium and lung. In addition to their utility as diagnostic markers, these autoantibodies may have a pathogenic role that helps localise disease to the synovium. Alongside the development of autoantibodies, other factors contributing to pre-symptomatic autoimmunity may include dysbiosis of the gastrointestinal tract, abnormal development of lymphoid tissue, and dysregulated autonomic and lipid-mediated anti-inflammatory signalling. These factors combine to skew the balance between pro-inflammatory and anti-inflammatory signalling in a manner that is permissive for the development of clinical arthritis. We present data to support the concept that the transitions from at-risk states to systemic autoimmunity and then to classifiable RA depend on multiple “switches”. However, further prospective studies are necessary to define the molecular basis of these switches and the specific features of pre-symptomatic autoimmunity, so that preventative treatments can be targeted to individuals at high risk for RA. In this review, we analyse mechanisms that may contribute to the development of autoimmunity in at-risk individuals and discuss the relationship between this pre-symptomatic state and subsequent development of RA.

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“…О связи между периодонтитом и разви-тием аутоиммунных нарушений, характерных для РА, сви-детельствует много фактов. У людей с генетическим рис-ком развития РА обнаружение антител к P. gingivalis в сы-воротке ассоциируется с гиперпродукцией АЦБ и РФ [147,148]. При РА обнаружен феномен аутоцитруллинирования ПАД P. gingivalis, ведущий к образованию антител к ПАД [149], который, однако, не характерен для «преклиниче-ской» фазы РА [150].…”

Section: фак торы внешней средыunclassified

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

Насонов¹

2017

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Periodontal Disease in Individuals With a Genetic Risk of Developing Arthritis and Early Rheumatoid Arthritis: A Cross‐Sectional Study

Abstract: This study shows that individuals with pre-RA have significant inflammatory periodontal involvement. There was a significant association between IgG against P. gingivalis and ACPAs in pre-RA and markers of RA activity in individuals with eRA.

Cited by 72 publications

References 51 publications

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

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