Periodontal disease in polycystic ovary syndrome

Dursun, Erhan; Akalın, Ferda Alev; Güncü, Güliz N.; Çınar, Neşe; Aksoy, Duygu Yazgan; Tözüm, Tolga F.; Kılınç, Kamer; Yıldız, Bülent

doi:10.1016/j.fertnstert.2010.07.1052

Cited by 55 publications

(78 citation statements)

References 30 publications

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“…[20] A higher prevalence of periodontal disease was observed in women with PCOS compared to women without PCOS (Healthy controls) in this study, though the participants in both the groups were matched in terms of possible confounding variables such as age and BMI. Similar findings were observed in a study conducted by Dursun et al [21] where women with PCOS showed higher periodontal indices. It is a well-documented fact that hormonal changes occurring during puberty, pregnancy, and menstrual cycles have an impact over the gingival health of women.…”

Section: Discussionsupporting

confidence: 90%

Prevalence of Periodontal Disease in Women With Polycystic Ovary Syndrome- A Comparative Descriptive Study

Nair¹,

Varma²,

Suragimath³

et al. 2017

jemds

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Section: Discussionsupporting

confidence: 90%

Prevalence of Periodontal Disease in Women With Polycystic Ovary Syndrome- A Comparative Descriptive Study

Nair¹,

Varma²,

Suragimath³

et al. 2017

jemds

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“…Sasıkala et al [36] indicated that MPO was an excellent inflammatory marker and showed elevated MPO levels in the ovarian and uterine tissues of PCOSinduced rats. Dursun et al [37] also found higher MPO levels in gingival cervicular fluid of women with PCOS. One of the mechanisms underlying the pathogenesis of PCOS is chronic low-grade inflammation and MPO is an enzyme released from activated neutrophils, and macrophages.…”

Section: Discussionmentioning

confidence: 86%

Serum myeloperoxidase and adenosine deaminase activities in polycystic ovary syndrome

Kurdoğlu

Özkol

Kurdoğlu

2011

Gynecological Endocrinology

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“…It was reported that gingivitis is frequently observed in patients with PCOS. [19][20][21] It is postulated that such peripheral and ovarian inflammation might be the precursor for insulin resistance, hypothalamic-pituitary-ovarian dysfunction and anovulation. 39 At least one-half of women with PCOS are obese, 40 or insulin resistant and hyperinsulinemic, independent of obesity.…”

Section: Correlationsmentioning

confidence: 99%

Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

et al. 2015

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This study aimed to investigate the levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitors of MMP-1 (TIMP-1) in saliva and serum samples of women with polycystic ovary syndrome (PCOS; n = 80) and matched systemically healthy controls (n = 45), with varying degrees of gingival inflammation. Salivary levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly elevated in women with PCOS, who also exhibited more gingivitis than systemically healthy women. No major changes were observed in salivary TIMP-1 levels with regard to PCOS. Serum levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly higher in women with PCOS, irrespective of the presence of gingivitis, while there were no differences in TIMP-1 levels. A positive correlation was indicated between probing depth, bleeding on probing, plaque index and salivary or serum MMP-8 levels or MMP-8/TIMP-1 ratio in the case of PCOS, while a negative such correlation was revealed for TIMP-1 in systemically healthy women. Increased levels of MMP-8 in saliva and serum seem to be more pronounced in women with PCOS, and potentiated in the presence of gingival inflammation. Alterations in MMP/TIMP system triggered by local and systemic inflammation may be implicated in the pathogenesis of PCOS, or the deterioration of its clinical presentation.

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Periodontal disease in polycystic ovary syndrome

Cited by 55 publications

References 30 publications

Prevalence of Periodontal Disease in Women With Polycystic Ovary Syndrome- A Comparative Descriptive Study

Prevalence of Periodontal Disease in Women With Polycystic Ovary Syndrome- A Comparative Descriptive Study

Serum myeloperoxidase and adenosine deaminase activities in polycystic ovary syndrome

Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

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