Periodontal Disease, Renal Dysfunction and Heightened Leukocytosis

Salimi, Saeedeh; Ng, Nawi; Seliger, Stephen L.; Parsa, Afshin

doi:10.1159/000366445

Cited by 18 publications

(20 citation statements)

References 46 publications

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“…This 4‐year longitudinal study of community‐dwelling older men and women found CKD was associated with a greater risk of AL progression. This finding supported previous cross‐sectional studies showing an association between CKD and periodontal disease …”

Section: Discussionsupporting

confidence: 93%

“…The principal exposure was the presence or absence of CKD, defined as an eGFR of <60 mL/min/1.73 m 2 . eGFR was calculated by using the abbreviated Modification of Diet in Renal Disease Study equation, with a Japanese coefficient of 0.881: eGFR (mL/min/1.73 m 2 ) = 0.881 × 186.3 × Age −0.203 × Serum‐creatinine −1.154 (if female × 0.742).…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have reported that CKD was associated with poor periodontal conditions . For example, a study conducted in England demonstrated that both prevalence and severity of periodontal disease among CKD patients were higher than among a geographically matched control population .…”

Section: Introductionmentioning

confidence: 99%

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Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4‐year cohort study

Iwasaki

Taylor

Sato

et al. 2019

Journal of Periodontology

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Background People with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse. Methods This 4‐year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community‐dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow‐up examinations. Multilevel logistic regression models estimated the tooth‐specific risk of AL progression (≥1 site exhibiting a ≥3 mm increase in AL) with baseline CKD (eGFR < 60 mL/min/1.73 m2) as the principal exposure. Results At baseline, 27.8% of the study population (108/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15–2.60). Conclusions The results suggest that CKD increases the risk of periodontal disease progression in older community‐dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

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Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4‐year cohort study

Iwasaki

Taylor

Sato

et al. 2019

Journal of Periodontology

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“…ORs (95% CI) assessing the association between periodontitis and CKD were considered (Figure ). Eight studies (Fisher & Taylor, ; Fisher, Taylor, Papapanou, Rahman, & Debanne, ; Fisher, Taylor, West, & McCarthy, ; Fisher, Taylor, Shelton, et al., ; Ioannidou, Hall, Swede, & Himmelfarb, ; Ioannidou & Swede, ; Ioannidou, Swede, & Dongari‐Bagtzoglou, ; Salimi, Ng, Seliger, & Parsa, ) were based on the NHANES III cohort, two studies on the D‐ARIC study (Grubbs et al., ; Kshirsagar et al., ), and two on Yokogoshi study (Yoshihara et al., , ). Therefore, only the study presenting the largest population sample in each subanalysis was pooled in this meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

et al. 2018

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A systematic review and meta-analysis were conducted to evaluate the association between periodontitis (PD) and chronic kidney disease (CKD) and to explore the potential influence of periodontal treatment in patients with CKD. Databases (PubMed, Web of Science, Science direct, Cochrane Database) were screened for relevant articles, focusing on the periodontal status of patients with CKD, published until December 2017. Five hundred and fifty-three articles were identified, and 37 fulfilled the inclusion criteria and were considered in this systematic review. Seventeen articles were included in the meta-analysis and 7 in the review focusing on the impact of periodontal treatment. Most of the identified studies indicated an increased incidence of PD in patients with CKD. Meta-analysis showed an association between CKD and PD, and strength of this association was increased when severe PD was considered (OR = 2.39 (1.70-3.36)). The association could be observed even after adjustment for major CKD risk factors or use of precise diagnosis criteria (OR = 2.26 for severe PD (1.69-3.01)). Analysis of cohort studies indicated an incident rate ratio (IRR) of 1.73. Periodontitis is associated with CKD after multivariable adjustment. Further studies are necessary to determine whether prevention or treatment of PD can reduce the incidence and/or severity of CKD.

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“…[29] Albuminuria has been shown to be related with periodontal disease. [30] A previous report showed that decreased kidney function (characterized by low eGFR) may be associated with periodontitis. [24] International recommendations suggest that the measurement of serum creatinine should be supplemented with eGFR using the MDRD study's equation.…”

Section: Discussionmentioning

confidence: 99%

Associations between the number of natural teeth and renal dysfunction

Choi

Han²,

Park³

et al. 2016

Medicine

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The purpose of the present study was to investigate the association between the number of natural teeth and measures of kidney dysfunction, such as urinary albumin/creatinine ratio (ACR) and estimated glomerular filtration (eGFR) rate, using nationally representative data.The data used were from the Korea National Health and Nutrition Examination Survey with cross-sectional design, which was conducted between 2011 and 2012; the sample analyzed in this study consisted of a total of 10,388 respondents, each of whom was 19 years or older and had no missing outcome variables. The association between the number of natural teeth and kidney function was assessed by multiple logistic regression and model was adjusted for age, sex, waist conference, smoking, drinking, exercise, education, income, frequency of tooth brushing per day, diabetes, metabolic syndrome, urinary ACR, and eGFR.The mean age, body mass index, and waist circumference were significantly higher among those with lower kidney function (urinary ACR ≥30 mg/g and eGFR <60 mL/min/1.73m2). Urinary ACR and eGFR were associated with loss of natural teeth. As urinary ACR increased, the number of natural teeth decreased accordingly. Conversely, the number of natural teeth increased with an increase in eGFR.This study showed that the number of natural teeth is inversely associated with the presence of kidney disease. Severity of tooth loss may be considered an independent risk indicator for kidney disease among Koreans. More epidemiological studies are warranted to investigate the role of tooth loss in kidney disease, to confirm this relationship and to test possible underlying mechanisms.

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Periodontal Disease, Renal Dysfunction and Heightened Leukocytosis

Cited by 18 publications

References 46 publications

Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4‐year cohort study

Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4‐year cohort study

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

Associations between the number of natural teeth and renal dysfunction

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