Periodontal Findings and Systemic Antibody Responses to Oral Microorganisms in Behçet's Disease

Çelenligil-Nazliel, Haviye; Kansu, Emin; Ebersole, Jeffrey L.

doi:10.1902/jop.1999.70.12.1449

Cited by 45 publications

(38 citation statements)

References 43 publications

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“…2. VOL. 15,2008 AGE, ORAL DISEASE, AND IMMUNITY IN NONHUMAN PRIMATES 1071 pected, with minimal previous evidence of this type of response except that reported in obese children and adolescents (86) and a general concept of a lack of systemic challenge in children in the absence of clinical changes, but it is consistent with the maturation of host responses in young animals that have to cope with a range of environmental challenges to naïve mucosal surfaces. Testing this concept, we compared these systemic responses in young animals housed under standard conditions with those in comparably aged SPF monkeys.…”

Section: Fig 5 Serumsupporting

confidence: 64%

“…Blood was collected from all animals, serum was prepared, and levels of immunoglobulin G (IgG) antibodies to seven oral bacteria were evaluated using an enzyme-linked immunosorbent assay (ELISA) as we have described previously (14,15). Briefly, Campylobacter rectus, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Treponema denticola, Tannerella forsythia, and Porphyromonas gingivalis were grown under anaerobic conditions in mycoplasma broth base with the addition of appropriate additives as we have reported previously (23).…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, Campylobacter rectus, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Treponema denticola, Tannerella forsythia, and Porphyromonas gingivalis were grown under anaerobic conditions in mycoplasma broth base with the addition of appropriate additives as we have reported previously (23). The bacteria were harvested by centrifugation, formalin killed, washed, and stored at Ϫ20°C for use as antigens (14,15).…”

Section: Methodsmentioning

confidence: 99%

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Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Ebersole

Steffen

González‐Martínez

et al. 2008

Clin Vaccine Immunol

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This report evaluated systemic inflammatory and immune biomarkers in a cohort of Macaca mulatta (rhesus monkeys) maintained as a large family social unit, including an age range from <1 year to >24 years. We hypothesized that the systemic host responses would be affected by the age, gender, and clinical oral presentation of the population, each contributing to inflammatory and immune responses that would reflect chronic oral infections. The results demonstrated that the prevalence and severity of periodontitis, including missing teeth, increased significantly with age. Generally, minimal differences in clinical parameters were noted between the genders. Systemic inflammatory mediators, including acute-phase reactants, prostaglandin E 2 (PGE 2 ), cytokines/chemokines, and selected matrix metalloproteinases (MMP), demonstrated significant differences among the various age groups of animals. Levels of many of these were increased with age, although PGE 2 , RANTES, bactericidal permeability-inducing factor (BPI), MMP-1, and MMP-9 levels were significantly increased in the young group (ϳ1 to 3 years old) relative to those for the older animals. We observed that in the adult and aged animals, levels of the systemic inflammatory mediators related to gingival inflammation and periodontal tissue destruction were significantly elevated. Serum antibody levels in response to a battery of periodontal pathogens were generally lower in the young animals, <50% of those in the adults, and were significantly related to aging in the cohort. The levels of antibodies, particularly those to Porphorymonas gingivalis, Fusobacterium nucleatum, and Tannerella forsythia, were most significantly elevated in animals with periodontal disease, irrespective of the age of the animal. These results provide a broad description of oral health and host responses in a large cohort of nonhuman primates from very young animals to the aged of this species. The findings afford a base of data with which to examine the ontogeny of host responses at mucosal sites, such as the gingival tissues.Periodontal disease is the predominant chronic inflammatory disease of humanity (37,38,78,82) and has been noted to occur naturally with increasing age in humans and nonhuman primates (36,63,69,88). This oral disease is an outcome of complex oral infections, chronic immunoinflammatory responses, and resulting destruction of soft and hard tissues of the periodontium (37,78,80,82,84). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (48), environmental stressors (6, 76, 85), and the genetic backgrounds of the individuals (3, 70, 84).The oral microbial characteristics of subgingival biofilms in younger and older individuals demonstrate differences in composition and complexity, which have been suggested to contribute directly to the microbial infections that trigger the destructive disease of oral tissues that occurs during aging (4,35,49,...

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Section: Fig 5 Serumsupporting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Ebersole

Steffen

González‐Martínez

et al. 2008

Clin Vaccine Immunol

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“…Nevertheless, antibiotics alone (aimed at Chlamydia pneumoniae or Helicobacter pylori, germs uncommon in periodontitis) failed to favorably alter the course of ischemic heart disease (Andraws, Berger, and Brown, 2005). Several infl ammatory diseases have been reported to be associated with severe periodontal disease such as Behcet disease (Akman et al 2007;Celenligil-Nazliel, Kansu, and Ebersole, 1999). None of our subjects had identifi ed active infl ammatory disease at inclusion.…”

Section: Discussionmentioning

confidence: 86%

Periodontitis and Calculated Risk of Cardiovascular Mortality

Boutouyrie

Bouchard

Mattout³

et al. 2008

Clinical medicine. Cardiology

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Epidemiological studies have reported associations between periodontitis and vascular disease in Europe. The aim of this multi-centric study was to evaluate the relationship between periodontitis and the calculated risk of cardiovascular death in the French adult population. The survey employed 2144 dentate adult subjects of the First National Periodontal and Systemic Examination Survey (NPASES I). This nationally representative sample was obtained by a quota method. The subjects had a complete full-mouth periodontal examination together with an evaluation of cardiovascular risk factors from laboratory tests, standard workup and questionnaires. Cardiovascular risk was calculated with the European SCORE scale calibrated for low risk populations. We found that age-independent cardiovascular risk increased with categories of periodontal disease (from 0.52 (health), 1.26 (slight), 1.69 (moderate) and 2.83 (severe). Cardiovascular mortality risk at 10 years (%), rose from 0.87 (health) to 1.83 (slight), 2.46 (moderate) and 3.94 (severe), p Ͻ 0.001. Our data show an association between periodontitis severity and the risk of cardiovascular death.

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“…In a recent study, Mumcu et al, (2006) have shown that oral health-related quality-of-life assessments were impaired in patients with BD and associated with disease activity and treatment modalities. Previous studies demonstrated that periodontal scores were higher in patients with BD than the healthy subject (Nakae et al, 1981;Celenligil-Nazlıel et al, 1999;Mumcu et al, 2004;Akman et al, 2007;Karaçaylı et al, 2009;Arabacı et al2009). Also, it has been speculated that BD might develop after the periodontitis and advenced periodontal disease may represent a risk factor for severe organ involvement (Akman et al, 2007).…”

Section: Relationship Between Periodontal Parameters and Behçet's Dismentioning

confidence: 92%

Causal or Causal Relationship Between Oral Diseases and Systemic Amyloidosis – From Inflammation to Amyloidosis – A Trouble Connection

Cengiz¹,

Cengiz²

2011

Amyloidosis - An Insight to Disease of Systems and Novel Therapies

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Periodontal Findings and Systemic Antibody Responses to Oral Microorganisms in Behçet's Disease

Cited by 45 publications

References 43 publications

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Periodontitis and Calculated Risk of Cardiovascular Mortality

Causal or Causal Relationship Between Oral Diseases and Systemic Amyloidosis – From Inflammation to Amyloidosis – A Trouble Connection

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