Periodontitis and Calculated Risk of Cardiovascular Mortality

Abstract

Epidemiological studies have reported associations between periodontitis and vascular disease in Europe. The aim of this multi-centric study was to evaluate the relationship between periodontitis and the calculated risk of cardiovascular death in the French adult population. The survey employed 2144 dentate adult subjects of the First National Periodontal and Systemic Examination Survey (NPASES I). This nationally representative sample was obtained by a quota method. The subjects had a complete full-mouth periodontal examination together with an evaluation of cardiovascular risk factors from laboratory tests, standard workup and questionnaires. Cardiovascular risk was calculated with the European SCORE scale calibrated for low risk populations. We found that age-independent cardiovascular risk increased with categories of periodontal disease (from 0.52 (health), 1.26 (slight), 1.69 (moderate) and 2.83 (severe). Cardiovascular mortality risk at 10 years (%), rose from 0.87 (health) to 1.83 (slight), 2.46 (moderate) and 3.94 (severe), p Ͻ 0.001. Our data show an association between periodontitis severity and the risk of cardiovascular death.

Relationship between periodontitis and risk of cardiovascular disease: Insights from the Tromsø Study

“…Our findings of a positive association between periodontitis Grade B/C and high cardiovascular risk as estimated by risk assessment model are consistent with previous, large population-based studies. [9][10][11][12] More recent studies from the United States (Hispanic/Latino population groups) 9 and South Korea 10,11 have applied the Framingham general CVD risk score, developed in 2008, which predicts the 10-year risk of general CVD 41 and has been widely used in epidemiological studies. 42,43 NORRISK 2 estimates 10-year risk of fatal and non-fatal cardiovascular events and is based on the European SCORE risk scoring tool.…”

“…Although an association between periodontitis and high cardiovascular risk has been reported, evidence from large scale epidemiological studies is still scarce. [9][10][11][12] It should be pointed out, however, that different populations might not be equally affected by periodontal disease, and cardiovascular risk profiles might also differ. More recent studies are limited to the United States (i.e., the Hispanic/Latino population) and South Korea.…”

“…[9][10][11] To the best of our knowledge, only one study (2008) that used cardiovascular risk as estimated by the systematic coronary risk evaluation (SCORE) risk assessment model has been conducted in a European cohort. 12 Smoking is a strong risk factor for periodontitis 13,14 and is also associated with increased cardiovascular risk. 8 Epidemiological studies on oral health and cardiovascular risk have shown that the confounding effect of smoking cannot be completely addressed, without restricting the study sample to never-smokers.…”

“…There have been minimal study on the extent to which periodontitis progression rate is associated with cardiovascular risk as estimated by risk assessment model. Although an association between periodontitis and high cardiovascular risk has been reported, evidence from large scale epidemiological studies is still scarce 9–12 . It should be pointed out, however, that different populations might not be equally affected by periodontal disease, and cardiovascular risk profiles might also differ.…”

“…More recent studies are limited to the United States (i.e., the Hispanic/Latino population) and South Korea 9–11 . To the best of our knowledge, only one study (2008) that used cardiovascular risk as estimated by the systematic coronary risk evaluation (SCORE) risk assessment model has been conducted in a European cohort 12 …”