Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic Fibroblast Growth Factor

Matsumoto, Goichi

doi:10.26717/bjstr.2018.04.001025

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Our HPLC analysis shows that more than 50% of HT concentration is preserved after preventing cross-linking reactions in irradiated phosphate buffer-based PEO hydrogels, and HT is almost totally preserved in citrate buffer-based PEO hydrogels. The anti-microbial properties of HT are helpful against microbial agents typical of periodontal diseases [15] or infected chronic skin wounds [16], thus making the molecule an ideal ingredient for the preparation of medical-grade hydrogels.…”

Section: Discussionmentioning

confidence: 99%

Hydroxy-tyrosol as a Free Radical Scavenging Molecule in Polymeric Hydrogels Subjected to Gamma-Ray Irradiation

et al. 2021

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Biomedical engineering is employing hydrogels with increasingly exciting possibilities for the treatment and regeneration of pathologically altered, degenerated, or traumatized tissues. Still, the sterilization processes may undesirably change the chemical and physical properties of hydrogels through cross-linking reactions. This work aims to characterize a new method of producing polyethylene oxide (PEO) hydrogels exploiting hydroxy-tyrosol (HT), an anti-oxidant molecule derived from olive leaf and olive oil, as a free radical scavenger to either prevent or limit gamma-ray-induced cross-linking. For this purpose, we produced hydrogels with PEO with two different buffer solutions (phosphate and citrate), varying HT concentration. We analyzed hydrogel preparations before and after gamma-ray irradiation, assessing the viscosity through rheological analysis and the chemical changes through IR analysis. We performed high-performance liquid chromatography (HPLC) analysis to measure residual HT in hydrogels after irradiation. The obtained results show that radiation-induced cross-linking and increase in viscosity of PEO hydrogels can be prevented by tailoring the concentration of HT as a free radical scavenging agent. Irradiation only consumes small amounts of HT; its presence in polymeric hydrogels can significantly impact biomedical applications by its anti-oxidant and anti-microbial activities.

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Section: Discussionmentioning

confidence: 99%

Hydroxy-tyrosol as a Free Radical Scavenging Molecule in Polymeric Hydrogels Subjected to Gamma-Ray Irradiation

et al. 2021

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“…Periodontal problems were treated with human fibroblast growth factor 2 containing hydrogels. Following 1 year of therapy, the clinical markers of periodontal wound healing improved dramatically in 30 patients ( Matsumoto, 2018 ). Tamura et al investigated the therapeutic benefits of prolonged release of basic fibroblast growth factor (bFGF) from gelatin hydrogels in patients with periodontal disease and bone abnormalities in separate research ( Matsumoto, 2018 ).…”

Section: Treatment Of Periodontitis Via Employing ...mentioning

confidence: 99%

“…Following 1 year of therapy, the clinical markers of periodontal wound healing improved dramatically in 30 patients ( Matsumoto, 2018 ). Tamura et al investigated the therapeutic benefits of prolonged release of basic fibroblast growth factor (bFGF) from gelatin hydrogels in patients with periodontal disease and bone abnormalities in separate research ( Matsumoto, 2018 ). Clinical metrics including probing pocket depth decrease, clinical attachment gain, and radiographic bone fill improved significantly 1 year following therapy.…”

Section: Treatment Of Periodontitis Via Employing ...mentioning

confidence: 99%

“…Clinical metrics including probing pocket depth decrease, clinical attachment gain, and radiographic bone fill improved significantly 1 year following therapy. Furthermore, no negative consequences were found ( Matsumoto, 2018 ). An injectable chitosan/gelatin thermoresponsive hydrogel loaded with BMP-2 as an osteoinductive biomolecule and T8IC nanoparticles as a photosensitizer was created to improve PDT and BMP-2 release.…”

Section: Treatment Of Periodontitis Via Employing ...mentioning

confidence: 99%

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Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

El-Nablaway,

Rashed,

Taher

et al. 2024

Front. Bioeng. Biotechnol.

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Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies and logical therapy procedures provides the foundation for effective periodontitis treatment. Being biocompatible, biodegradable, and easily administered to the periodontal tissues, hydrogels have sparked substantial an intense curiosity in the discipline of periodontal therapy. The primary objective of hydrogel research has changed in recent years to intelligent thermosensitive hydrogels, that involve local adjustable sol-gel transformations and regulate medication release in reaction to temperature, we present a thorough introduction to the creation and efficient construction of new intelligent thermosensitive hydrogels for periodontal regeneration. We also address cutting-edge smart hydrogel treatment options based on periodontitis pathophysiology. Furthermore, the problems and prospective study objectives are reviewed, with a focus on establishing effective hydrogel delivery methods and prospective clinical applications.

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Long Term Observation of Guided Tissue Regeneration with Bone Swaging Technique

Kodama

2019

Journal of the Japanese Society of Periodontology

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Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic Fibroblast Growth Factor

Cited by 3 publications

References 24 publications

Hydroxy-tyrosol as a Free Radical Scavenging Molecule in Polymeric Hydrogels Subjected to Gamma-Ray Irradiation

Hydroxy-tyrosol as a Free Radical Scavenging Molecule in Polymeric Hydrogels Subjected to Gamma-Ray Irradiation

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

Long Term Observation of Guided Tissue Regeneration with Bone Swaging Technique

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