Periodontal status of candidates for allogeneic hematopoietic stem cell transplantation

Nuernberg, Marta Aparecida Alberton; Rodrigues, Suelen Caroline; Perdoncini, Nicole Nichele; Funke, Vaneuza Araújo Moreira; Bonfim, Carmem; Nabhan, Samir Kanaan; Torres‐Pereira, Cassius Carvalho

doi:10.1111/scd.12229

Cited by 3 publications

(7 citation statements)

References 39 publications

(87 reference statements)

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“…Therefore, the effects of periodontitis and poor oral health on treatment outcomes and oral comorbidity post‐HSCT are not clear and warrant further study. However, periodontal diseases are, at least, common in HSCT recipients . Our results on periodontitis are consistent with previous studies, as in the current study, a high prevalence of periodontitis, in terms of RAL >3 mm, was observed in 53.8% of these HSCT recipients .…”

Section: Discussionsupporting

confidence: 93%

“…18,19,35 Our results on periodontitis are consistent with previous studies, as in the current study, a high prevalence of periodontitis, in terms of RAL >3 mm, was observed in 53.8% of these HSCT recipients. 18,19,35 Periodontitis was slightly more prevalent in HSCT recipients com- Diamanti-Kipioti, the bone level in panoramic radiographs was considered to be normal if the distance between CEJ and AC was up to 3 mm. Therefore, alveolar bone was considered lost, indicating periodontitis, if the CEJ-AC distance was >3 mm.…”

Section: Discussionsupporting

confidence: 92%

“…However, periodontal diseases are, at least, common in HSCT recipients . Our results on periodontitis are consistent with previous studies, as in the current study, a high prevalence of periodontitis, in terms of RAL >3 mm, was observed in 53.8% of these HSCT recipients . Periodontitis was slightly more prevalent in HSCT recipients compared with the controls, but the result was not statistically significant.…”

Section: Discussionsupporting

confidence: 89%

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Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Uutela

Passweg

Weiger

et al. 2019

European J of Haematology

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Objectives:The purpose of this study was to compare the prevalence of common oral diseases between allogeneic haematopoietic stem cell transplantation (HSCT) recipients and healthy controls. Materials and methods:A total of 143 adult allogeneic HSCT recipients who were treated for haematological malignancies between 2008 and 2016 were included in the study. The HSCT recipients were age and sex matched with healthy controls. A dental examination was performed on the HSCT recipients prior to HSCT. Differences in stimulated saliva flow rate (SSFR), decayed, missing and filled teeth (DMFT) index, number of teeth, number of caries lesions, and measures of current or previous periodontitis (radiological attachment loss >3 mm or probing pocket depth ≥4 mm) between HSCT recipients and controls were examined. Results: Stimulated saliva flow rate, DMFT index and the number of caries lesions were poorer in the HSCT recipients pre-HSCT compared to controls (all P-values <0.05). No statistically significant differences in the measures of current or previous periodontitis were observed.Conclusions: Stimulated saliva flow rate was low and caries was common in HSCT recipients prior to HSCT. Efficient preventive strategies are important in order to maintain the oral health of these patients. K E Y W O R D Scaries, DMFT, haematology, periodontitis, stem cell transplantation

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Uutela

Passweg

Weiger

et al. 2019

European J of Haematology

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“…There are few studies evaluating the oral health condition in patients with FA. Although the dental caries index and the oral hygiene index in patients with FA are similar those in people without FA, their oral health is still poor, and they have an increased tendency toward periodontal diseases …”

Section: Risk Factors and Prevention Of Oscc In Famentioning

confidence: 99%

“…Although the dental caries index and the oral hygiene index in patients with FA are similar those in people without FA, 62 their oral health is still poor, 62-64 and they have an increased tendency toward periodontal diseases. [63][64][65] Pathogenic bacteria colonization increases with poor oral hygiene, 66 and evidence suggests an etiological role of oral bacteria in OSCC initiation and development. The cellular mechanisms leading to inflammation, DNA damage, epigenetic DNA modifications, and carcinogenic metabolites are ways by which the local microbiome can contribute toward carcinogenesis.…”

Section: Risk Factors and Prevention Of Oscc In Famentioning

confidence: 99%

Two enemies, one fight: An update of oral cancer in patients with Fanconi anemia

Amenábar

Torres‐Pereira

Tang

et al. 2019

Cancer

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Fanconi anemia (FA) is a rare inherited genetic condition that may lead to bone marrow failure, leukemia, and/or solid tumors. It is caused by the loss of function of at least 1 gene of the FA/BRCA pathway, which is necessary for DNA repair. Patients with FA have a 200‐fold to 1000‐fold risk of developing head and neck cancer, mainly oral squamous cell carcinoma (OSCC), and of doing so at a much younger age than individuals within the general population. Also, patients who have FA with OSCC have poor overall survival rates, reinforcing the necessity to detect OSCC early. The scope of the current review is to provide an update on OSCC in patients with FA.

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Self-perception of periodontal health status among individuals with Fanconi anemia

Perdoncini

Furquim

Bonfim

et al. 2021

Hematology, Transfusion and Cell Therapy

Self Cite

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Introduction Fanconi anemia (FA) is a rare genetic disease characterized by congenital malformations and bone marrow failure. One of the most common oral diseases in individuals with FA is periodontitis and adequate self-perception of periodontal status could contribute to its prevention and early detection. Aim To compare oral health self-perception, measured by a questionnaire, with the clinical oral condition of patients with FA. Methods and Results Fifty-six patients with FA, over 11 years of age, answered a questionnaire about dental history and self-reported oral health. Decayed, missing, and filled teeth (DMFT), Visible Plaque Index (VPI) and Gingival Bleeding Index (GBI) were measured. The median age of participants was 21 years (min 11, max 44), 31 (55%) were females and 25 (45%) males. Thirty-five (62.5%) participants rated their oral condition as satisfactory and 7 (12.5%) participants reported tooth mobility, 10 (17.9%) exposed roots and 21 (37.5%) gingival bleeding. Clinical examination detected average DMFT = 5.23, VPI = 31.36% and GBI = 33.77%. The gingival bleeding report was more frequent among individuals with higher GBI ( p =  0.014). The DMFT was higher in those who had already undergone dental treatments ( p =  0.031). There was an association between participants who presented dental caries and who rated their oral health as poor ( p =  0.03). The question “Do your gums bleed easily?” had good accuracy in the evaluation of periodontal disease ( p =  0.68). Conclusion Oral health self-perception of individuals with FA about gingival inflammation was associated with their gingival bleeding index.

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Periodontal status of candidates for allogeneic hematopoietic stem cell transplantation

Abstract: The candidates for allogeneic HSCT studied showed a high prevalence of periodontal diseases with unmonitored local infection before transplantation.

Cited by 3 publications

References 39 publications

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Two enemies, one fight: An update of oral cancer in patients with Fanconi anemia

Self-perception of periodontal health status among individuals with Fanconi anemia

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