Periodontal Vaccine—A Boon In Periodontics

Kumar, Anil; B, Sharnamma; Dutt, Poonam; Gupta, Gunjan

doi:10.9790/0853-13415459

Cited by 2 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The subgingival biofilm associated bacteria are found to exacerbate diabetes and cardiovascular disease and it has been suggested that immunotherapy for periodontal disease may be considered as a second indication for controlling atherosclerosis. [17] Another group of patients that would benefit from the use of such a vaccine are immunocompromised patients affected by the disease through various acquired or congenital causes. [18] Periodontal treatment lays a monetary load on the individuals suffering from it.…”

Section: Dna Vaccinationmentioning

confidence: 99%

Periodontal Vaccine- A Shot in the Arm!

Gajghate¹,

Ansari²,

Malik³

et al. 2020

IJAR

View full text Add to dashboard Cite

Periodontal diseases are immune inflammatory responses induced by dental plaque in which microorganisms harboured within a susceptible periodontium contributes to tissue destruction, bone loss and eventually tooth loss. The etiopathogenesis of periodontal disease is multifactorial which includes host associated factors, genetic factors, immune system dysfunction and environmental factors. Existing treatment modalities have resulted only in arresting the disease progression but have not cured the disease completely, nor do they avert the recurrence. Hence there is a need for therapeutic modalities which may include vaccines targeting periodontal pathogens. Vaccination is induction of immunity by injecting a dead or attenuated form of pathogen. Till date, no pre-emptive modality exists for periodontal disease, the availability of periodontal vaccine would prevent the progression of periodontal diseases. The aim of this review article is to confer the various approaches associated with periodontal vaccine.

show abstract

Section: Dna Vaccinationmentioning

confidence: 99%

Periodontal Vaccine- A Shot in the Arm!

Gajghate¹,

Ansari²,

Malik³

et al. 2020

IJAR

View full text Add to dashboard Cite

show abstract

“…In the early 20th century, three periodontal vaccines were employed [8,9,16] pure cultures of streptococcus and other organism, autogenous vaccines and stock vaccines eg. Vancott's vaccine, Inava endocarp vaccine.…”

Section: History Of Periodontal Vaccinesmentioning

confidence: 99%

Periodontal Vaccine-Armour against Periodontitis

Bhardwaj¹

2019

OAJDS

View full text Add to dashboard Cite

The main etiologic factor of periodontitis is oral biofilm comprising of various microorganisms. Studies have shown that there is considerable potential for intervention with the host immune system. Periodontal vaccination is indicated in patients with severe periodontal disease with advanced bone loss. Immunization can be brought about by both whole bacterial cells or one or more of its antigenic components. However, complexity of periodontal pathogenic flora poses a complication in the determination of antigen for the vaccine. Numerous invitro studies and animal studies have proved beyond doubt the efficacy periodontal vaccination. The challenge we face today is the translation of similar results in humans.

show abstract

Periodontal Vaccine—A Boon In Periodontics

Cited by 2 publications

References 25 publications

Periodontal Vaccine- A Shot in the Arm!

Periodontal Vaccine- A Shot in the Arm!

Periodontal Vaccine-Armour against Periodontitis

Contact Info

Product

Resources

About