Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

Cho, Young‐Dan; Kim, Kyoung-Hwa; Lee, Yong-Moo; Ku, Young; Seol, Yang‐Jo

doi:10.3390/ph14050456

Cited by 87 publications

(69 citation statements)

References 105 publications

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“…Epithelial-mesenchymal interactions (EMT) are important for the development of ectodermal organs and for tissue regeneration and wound healing, including cellular events such as cell adhesion, proliferation, differentiation, and maturation [26]. Homeostasis, inflammation, migration and proliferation, and remodeling are the four major processes of wound healing [27]. Fibroblast growth factor 2 (FGF2) and its receptor, fibroblast growth factor receptor 2 (FGFR2), are crucial for proliferation, migration, and protease production in epithelial cells [28].…”

Section: Fluoride and Epithelial-mesenchymal Interactionsmentioning

confidence: 99%

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Wang

Tewari

Sato

et al. 2022

IJMS

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Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.

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Section: Fluoride and Epithelial-mesenchymal Interactionsmentioning

confidence: 99%

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Wang

Tewari

Sato

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…It consists of four components: gingiva, periodontal ligament, cementum, and alveolar bone. Severe inflammation of the periodontium is associated with progressively worsening periodontal bone defects resulting in tooth mobility or loss [64,65]. Several biomaterials have been developed as a 3D scaffold to provide an appropriate microenvironment and facilitate good periodontal regenerative outcomes [65,66].…”

Section: Use Of Chitosan Scaffolds In Regenerative Dentistrymentioning

confidence: 99%

Chitosan-Based Scaffold for Mineralized Tissues Regeneration

et al. 2021

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Conventional bone grafting procedures used to treat bone defects have several limitations. An important aspect of bone tissue engineering is developing novel bone substitute biomaterials for bone grafts to repair orthopedic defects. Considerable attention has been given to chitosan, a natural biopolymer primarily extracted from crustacean shells, which offers desirable characteristics, such as being biocompatible, biodegradable, and osteoconductive. This review presents an overview of the chitosan-based biomaterials for bone tissue engineering (BTE). It covers the basic knowledge of chitosan in terms of biomaterials, the traditional and novel strategies of the chitosan scaffold fabrication process, and their advantages and disadvantages. Furthermore, this paper integrates the relevant contributions in giving a brief insight into the recent research development of chitosan-based scaffolds and their limitations in BTE. The last part of the review discusses the next-generation smart chitosan-based scaffold and current applications in regenerative dentistry and future directions in the field of mineralized tissue regeneration.

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“…This means that while the benefits of regenerative periodontal surgeries seem evident in infrabony pockets, more research is needed to make these techniques applicable in suprabony pockets. Furthermore, DM patients are at higher risk of post-surgical infection and impaired wound healing [ 72 ].…”

Section: Current Periodontal Therapies In Diabeticsmentioning

confidence: 99%

The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium

et al. 2021

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Periodontitis and diabetes mellitus (DM) are two of the most common and challenging health problems worldwide and they affect each other mutually and adversely. Current periodontal therapies have unpredictable outcome in diabetic patients. Periodontal tissue engineering is a challenging but promising approach that aims at restoring periodontal tissues using one or all of the following: stem cells, signalling molecules and scaffolds. Mesenchymal stem cells (MSCs) and insulin-like growth factor (IGF) represent ideal examples of stem cells and signalling molecules. This review outlines the most recent updates in characterizing MSCs isolated from diabetics to fully understand why diabetics are more prone to periodontitis that theoretically reflect the impaired regenerative capabilities of their native stem cells. This characterisation is of utmost importance to enhance autologous stem cells based tissue regeneration in diabetic patients using both MSCs and members of IGF axis.

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Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

Cited by 87 publications

References 105 publications

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Chitosan-Based Scaffold for Mineralized Tissues Regeneration

The Effect of Diabetes Mellitus on IGF Axis and Stem Cell Mediated Regeneration of the Periodontium

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