Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues

Könönen, Eija; Gürsoy, Mervi; Gürsoy, Ulvi Kahraman

doi:10.3390/jcm8081135

Cited by 548 publications

(454 citation statements)

References 94 publications

Supporting

Mentioning

438

Contrasting

Unclassified

Order By: Relevance

“…Part 1 (domains 1-5) has 4 response categories rating the extent of agreement (see Table 1). Part 2 (domains 6-9) has 5 response categories rating the level of difficulty: cannot do or always difficult (1), usually difficult (2), sometimes difficult (3), usually easy (4) and always easy (5). Each domain was scored as the average of the item scores [23].…”

Section: Methodsmentioning

confidence: 99%

“…Conversely, changes in the balance between different bacterial species that live in the human body contribute to the pathogenesis of some diseases [4]. A change in the composition of the subgingival microbiome is one of the most common causes of periodontal disease [5,6]. Periodontitis is a microbial infection that is manifested by inflammation of the gingival tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Our immune system reacts to its presence and pro-inflammatory molecules are released. The extent of damage to the epithelium, gingiva, pendulum apparatus of teeth/gingival connective tissue, cement and bone depends on the type of immune defense response of each individual [5,6]. This suggests that periodontitis may manifest concurrently with other systemic diseases [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Health Literacy Associations with Periodontal Disease among Slovak Adults

Timkova

Klamárová

Kovaĺová

et al. 2020

IJERPH

View full text Add to dashboard Cite

Periodontal disease is inflammation of the gums and without good oral hygiene, it can progress to periodontitis. Oral hygiene might be related to a patient’s health literacy (HL), defined as ability to gain access, understand, and use information to promote and maintain good health. The aim of our study is to examine the associations of HL with indicators of periodontal disease. A cross-sectional study on 1117 adults (36.2% males; mean age = 36.4, SD = 14.2) attending dental hygiene treatment was conducted. Data on demographics, socioeconomic status, and nine domains of HL (Health Literacy Questionnaire, HLQ) were collected by questionnaire, and Community Periodontal Index of Treatment Needs (CPITN) was established by the dental hygienist. Data were analysed using t-tests and logistic regression. Respondents with periodontal disease (N = 152) had statistically significantly lower levels of HL in seven out of nine HLQ domains compared to intact patients (N = 818) (t from 3.03 to 4.75, p < 0.01). Association of higher HL in seven domains with lower chance of diagnosed periodontal disease remain significant even after adjustment for age, gender and educational attainment (adjusted ORs 0.55–0.67, p < 0.05). Our findings confirm that an individual’s lower HL is significantly associated with higher chance of periodontal disease incidence, specifically among Slovak adults attending oral hygiene clinics. HL might be a promising factor in the improvement of oral health in this population, worthy of consideration in intervention and preventive activities.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health Literacy Associations with Periodontal Disease among Slovak Adults

Timkova

Klamárová

Kovaĺová

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…These bacteria, organized in biofilms with other commensal species, colonize the root surface, eliciting a chronic inflammation which leads to the progressive destruction of alveolar bone and collagen fibers of the periodontal ligament, and to the formation of periodontal pockets [2]. Genetics, environmental and behavioral factors influence disease development, the exposure of susceptible individuals to its initiation, and the speed of progression [3]. The inflammatory process is regulated by several biomolecular response mediators that may induce a quite disproportional reaction, leading to connective tissue damage [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Radiographic Evaluation of Nanohydroxyapatite Powder in Combination with Polylactic Acid/Polyglycolic Acid Copolymer as Bone Replacement Graft in the Surgical Treatment of Intrabony Periodontal Defects: A Retrospective Case Series Study

Verardi

Lombardi²,

Stacchi³

2020

Materials

View full text Add to dashboard Cite

The aim of this retrospective case series was to evaluate the clinical efficacy of nanohydroxyapatite powder (NHA) in combination with polylactic acid/polyglycolic acid copolymer (PLGA) as a bone replacement graft in the surgical treatment of intrabony periodontal defects. Medical charts were screened following inclusion and exclusion criteria. Periodontal parameters and periapical radiographs taken before surgery and at 12-month follow-up were collected. Intra-group comparisons were performed using a two-tailed Wilcoxon signed-rank test. Twenty-five patients (13 males, 12 females, mean age 55.1 ± 10.5 years) were included in the final analysis. Mean probing depth (PD) and clinical attachment level (CAL) at baseline were 8.32 ± 1.41 mm and 9.96 ± 1.69 mm, respectively. Twelve months after surgery, mean PD was 4.04 ± 0.84 mm and CAL was 6.24 ± 1.71 mm. Both PD and CAL variations gave statistically significant results (p < 0.00001). The mean radiographic defect depth was 5.54 ± 1.55 mm and 1.48 ± 1.38 mm at baseline and at 12-month follow-up, respectively (p < 0.0001). This case series, with the limitations inherent in the study design, showed that the combination of NHA and PLGA, used as bone replacement graft in intrabony periodontal defects, may give significant improvements of periodontal parameters at 12-month follow-up.

show abstract

“…The oral microbiota plays an important role in the relationship between periodontitis and diabetes (9) since it influences glycemic control (10). Certain bacteria such as Porphyromonas gingivalis , one of the main strains of periodontal disease, releases a lipopolysaccharide (LPS), which triggers numerous pro-inflammatory cytokines that are responsible for periodontal tissue destruction as well as increases insulin resistance (1, 11, 12).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the oral microbiome of medically controlled type-2 diabetes patients

Santos

Martins-Mendes

Gayà-Vidal

et al. 2020

Preprint

View full text Add to dashboard Cite

28Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is becoming a 29 significant global health care problem. Several studies have shown that people with 30 diabetes are more susceptible to oral problems, such as periodontitis and, although the 31 causes are still inconclusive, the oral microbiota seems to be an important factor in this 32 interaction. This study aimed to characterize the oral microbiome of a sample representing 33 T2DM patients from Portugal and exploit potential associations between some 34 microorganisms and variables like teeth brushing, smoking habits, and nutrient intake. 35 By sequencing the hypervariable regions V3-V4 of the 16S rRNA gene in 50 individuals 36 belonging to a group of diabetes patients and a control group, we found a total of 233 37 taxa, from which only 65% were shared between both groups. No differences were found 38 in terms of alpha and beta diversity between groups or habits categories. Also, there were 39 no significant differences in the oral microbiome profiles of control and diabetes patients. 40Only the class Synergistia and the genus TG5, which are related to periodontitis, were 41 statistically more frequent in the control group. This finding can be justified by the fact 42 that these diabetic patients usually have their oral health under close medical control than 43 an average healthy person, which in this study was represented by the control group. 44 45 IMPORTANCE: Diabetes has become a significant global health care issue as its 46 incidence continues to increase exponentially, with type 2 diabetes being responsible for 47 more than 90% of these cases. Portugal is one of the countries with a higher prevalence 48 of diabetes in Europe. It has been reported that diabetic people have an increased risk of 49 developing several health problems such as oral infections mostly caused by opportunistic 50 pathogens. Some studies have pointed out a relationship between diabetes and oral 51 3 microbiome. Therefore, the characterization of the microbial ecosystem of the mouth in 52 reference groups is crucial to provide information to tackle oral health pathogen-borne 53 conditions. In this study, we provide the first characterization of the oral microbiome of 54 type 2 diabetes mellitus patients from Portugal, and therefore, contributing new data and 55 knowledge to elucidate the relationship between diabetes and the oral microbiome. 56 57 58 59 60 61 62 Keywords: oral microbiome, type 2 diabetes mellitus, 16S rRNA gene sequencing, 63 microbiota, Next-Generation Sequencing, Portugal 64 65 67hyperglycemia caused by defects in insulin secretion, which can contribute to the 68 development of resistance to its action (1, 2). T2DM is becoming more common, also in 69 children and adolescents, and therefore, represents a significant global health care 70 problem (3). 71As more studies are focused on the impact of T2DM on the medium-term patients' health, 72 a growing number of studies have been reporting a close association between diabetes 73 and susce...

show abstract

Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues

Cited by 548 publications

References 94 publications

Health Literacy Associations with Periodontal Disease among Slovak Adults

Health Literacy Associations with Periodontal Disease among Slovak Adults

Clinical and Radiographic Evaluation of Nanohydroxyapatite Powder in Combination with Polylactic Acid/Polyglycolic Acid Copolymer as Bone Replacement Graft in the Surgical Treatment of Intrabony Periodontal Defects: A Retrospective Case Series Study

Characterization of the oral microbiome of medically controlled type-2 diabetes patients

Contact Info

Product

Resources

About