Periodontitis and Anti‐Neutrophil Cytoplasmic Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Comparative Study

Novo, Ernesto; Garcia-MacGregor, Ernesto; Viera, Ninoska; Chaparro, Neira; Crozzoli, Yolanda

doi:10.1902/jop.1999.70.2.185

Cited by 60 publications

(71 citation statements)

References 28 publications

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“…The finding that periodontitis is a plausible risk factor for cardiovascular diseases (2), stroke (41), rheumatoid arthritis (26), and premature birth (27) adds a new perspective to the importance of oral health. The increased bacterial burden in the inflamed periodontal pockets often leads to the presence of oral bacteria and their components in the systemic circulation (5,15).…”

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confidence: 99%

Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies

et al. 2002

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Periodontitis is a common chronic oral infection caused by gram-negative bacteria, including Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontitis evokes inflammatory host response locally in the periodontium but also systemically. The systemic humoral antibody response against oral pathogens can conveniently be measured by an immunoassay. The aim of the study was to measure serum immunoglobulin G class antibodies against A. actinomycetemcomitans and P. gingivalis by an enzyme-linked immunosorbent assay (ELISA) in which mixtures of several serotypes of the pathogens were used as antigens to avoid biasing of the results in favor of a particular strain. For A. actinomycetemcomitans the antigen consisted of six strains representing serotypes a, b, c, d, and e and one nonserotypeable strain. In the P. gingivalis ELISA, antigens representing serotypes a, b, and c were used. Serum samples from 90 subjects, including 35 samples from patients with diagnosed periodontitis, 10 samples from periodontally healthy controls, and 45 samples from randomly selected apparently healthy volunteers (referred to as "healthy subjects"), were tested. For both pathogens the antibody levels (means ؎ standard deviations) of the patients-expressed as area under the dilution curve-were significantly higher than those for healthy controls or healthy subjects, with values for A. actinomycetemcomitans and P. gingivalis, respectively, as follows: patients, 22.

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confidence: 99%

Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies

et al. 2002

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“…En el caso de individuos con Artritis Reumatoidea, se presentaron alteraciones orofaciales, que probablemente se relacionan con factores endógenos (sistémicos e inmunológicos) y exógenos (microbiología e higiene oral). [10][11][12][13][14][15] Estos pacientes tienen mayor riesgo de padecer una enfermedad periodontal, ya que la enfermedad compromete el sistema inmunológico. [13][14][15] Se corrobora con un 50% de enfermedad periodontal, aquí registrada.…”

Section: Discussionunclassified

“…[10][11][12][13][14][15] Estos pacientes tienen mayor riesgo de padecer una enfermedad periodontal, ya que la enfermedad compromete el sistema inmunológico. [13][14][15] Se corrobora con un 50% de enfermedad periodontal, aquí registrada.…”

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Manifestaciones Orales en Pacientes Con Artritis Reumatoidea Que Asisten Al Instituto De Rehabilitación Y Reumatologia De Bucaramanga

et al. 2018

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RESUMENObjetivo: Determinar el perfil orofacial y bucodental de individuos con Artritis Reumatoidea, según la evolución y el manejo de la enfermedad Materiales y métodos: Mediante un estudio observacional descriptivo, conformado por 48 individuos con Artritis Reumatoidea, se estableció la prevalencia de las alteraciones en el examen facial, articulación temporomandibular (ATM), examen intraoral, índice COP, estado periodontal (CPITN), ICP e interpretación radiográfica. Resultados: Se valoraron 48 individuos, 77.08% del género femenino, con un promedio de edad de 48.7 años. El cuero cabelludo presentó la mayor frecuencia de anormalidad, 22.9%; la alteración de la ATM más frecuente fue el dolor articular (60.42%) que fue bilateral en un 41.67%; en mucosa oral, la zona bucal presentó el mayor número de lesiones (37,5%); el 50% de los individuos presentó bolsas de 4 a 5mm con presencia de cálculos subgingivales. En la interpretación radiográfica se observó un 19.05% con raíces delgadas; el 42.86% presentó hipercementosis en la zona posterior; el 11.90%, espacio articular reducido. Conclusiones: Las alteraciones de la mucosa oral reflejan una prevalencia elevada de lesiones en la mucosa bucal. Además, la mayoría de los individuos corren el riesgo de presentar enfermedad periodontal. Results: In the group studied, 77.08% were female and their average mean age was 48.7% years old. The scalp showed the highest frequency of abnormality, 22.9%; the most frequent TMJ alteration was pain, 60.42% which was 41.67% bilateral; oral mucosa showed the greatest number of lesions (37.5%); the periodontal condition was 50% of the population had periodontal pockets of 4 to 5 mm in the presence of subgingival calculus. Radiographically, 19.05% had thin roots; 42.86% had posterior hypercementosis; 11.9% reduced TM joint space. Conclusions: The alterations of the oral mucosa reflect an elevated prevalence of red lesions. Furthermore, these patients have a greater risk of developing periodontal disease.

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“…Embora a doença periodontal (DP) e o LES apresentem etiologias distintas, mecanismos destrutivos semelhantes, ocasionados por desregulações do sistema inato, poderiam explicar a possível associação entre estas duas condições crônicas (37) . Estudos mais recentes sugerem um possível envolvimento do polimorfismo gênico de citocinas como IL-10, TNF e receptor Fc da imunoglobulina G tanto na DP quanto no LES (23) .…”

Section: Aspectos Dentais E Periodontaisunclassified

Achados bucais e laboratoriais em pacientes com lúpus eritematoso sistêmico

Júnior¹,

Cantisano

Klumb³

et al. 2010

J. Bras. Patol. Med. Lab.

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Periodontitis and Anti‐Neutrophil Cytoplasmic Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Comparative Study

Cited by 60 publications

References 28 publications

Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies

Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies

Manifestaciones Orales en Pacientes Con Artritis Reumatoidea Que Asisten Al Instituto De Rehabilitación Y Reumatologia De Bucaramanga

Achados bucais e laboratoriais em pacientes com lúpus eritematoso sistêmico

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