Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate

Chambrone, Leandro; Foz, Adriana Moura; Guglielmetti, Mariana Rocha; Pannuti, Cláudio Mendes; Artese, Hilana Paula Carillo; Feres, Magda; Romito, Giuseppe Alexandre

doi:10.1111/jcpe.12067

Cited by 147 publications

(167 citation statements)

References 59 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…It has been generally accepted that periodontitis could be an important risk factor for CKD and kidney failure (Chambrone et al, 2013) based on the following two points: (a) systemic inflammation is affected by periodontal inflammation and (b) periodontal bacteria and/or their products can enter the bloodstream (Kshirsagar et al, 2005). In addition, the oral health of patients undergoing dialysis therapy is frequently found to be poor due to insufficient oral hygiene caused by their poor condition.…”

Section: Discussionmentioning

confidence: 99%

“…Although the timing for initiation of dialysis remains controversial, many physicians recommend initiating the dialysis therapy when the eGFR is <15 ml min −1 1.73 m − 2 (Churchill, 1997), so this recommendation has an impact on both clinical practice and medical expenses. It has been found that periodontal treatment improves the eGFR in CKD patients (Chambrone et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixty‐four patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a cross‐sectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1–G5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1‐4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Naruishi

Oishi

Inagaki

et al. 2016

Clinical & Exp Dental Res

View full text Add to dashboard Cite

show abstract

“…Chronic periodontitis constitutes one of the factors that contribute to the development of chronic kidney disease, and the relationship between those two entities is bi-directional [15][16][17][18][19].…”

Section: Chronic Kidney Disease and Periodontal Statusmentioning

confidence: 99%

Oral Health in Chronic Kidney Disease Patients: A Literature Review

Rabiega¹,

Eliasz²,

Pawlaczyk³

2016

Dent. Med. Probl.

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a broad term used to describe progressive structural and functional kidney disorders that may be accompanied by a decrease in the glomerular filtration rate (GFR), and that have lasted for at least 3 months [1]. The diagnosis of CKD is also made if GFR values are below 60 mL/min/1.73 m 2 for a minimum of 3 months, independently of the presence of kidney damage markers [2,3]. There are several symptoms that can indicate CKD in patients, e.g. abnormalities visible in diagnostic imaging procedures, in blood and urine tests (e.g. proteinuria, abnormal urine sediment) or blood morphology. GFR is, however, the most important factor when it comes to the physiopathology of chronic kidney disease. Nowadays, CKD is classified into five stages, according to the value of this index: stage 1 (GFR > 90 mL/ /min/1.73 m 2 ), stage 2 (60-89 mL/min/1.73 m 2 ), stage 3 (30-59 mL/min/1.73 m 2 ), stage 4 (15-29 mL/min/1.73 m 2 ) and stage 5 (GFR < 15 mL/ /min/1.73 m 2 ). Stage 3 can be further divided into 3A (45-59 mL/min/1.73 m 2 ) and 3B (30-44 mL/ /min/1.73 m 2 ). Stage 5, the most advanced and dangerous one, is also described as "end-stage renal failure" (ESRF), and constitutes an indica-REVIEWS

show abstract

“…2013년에 발표된 치주염과 만성신장질환에 관한 체계적 고찰에서는 치주염이 있는 환자들이 약 1.6배 만성신장질환 에 대한 위험이 높게 나타났다 13) . "periodontal disease" OR "gingival disease" OR "periodontitis" OR "gingivitis" OR "alveolar bone loss":ti,ab,kw (Word variations have been searched)…”

unclassified

Relationship between Periodontal Disease and Chronic Kidney Disease: A Systematic Review of Cohort Studies

Lee

2017

J Dent Hyg Sci

View full text Add to dashboard Cite

Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate

Abstract: There is quite consistent evidence to support the positive association between periodontitis and CKD, as well as the positive effect of PT on eGFR.

Cited by 147 publications

References 59 publications

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Association between periodontal condition and kidney dysfunction in Japanese adults: A cross‐sectional study

Oral Health in Chronic Kidney Disease Patients: A Literature Review

Relationship between Periodontal Disease and Chronic Kidney Disease: A Systematic Review of Cohort Studies

Contact Info

Product

Resources

About